journal1 ›› 2018, Vol. 26 ›› Issue (7): 717-720.DOI: 10.11852/zgetbjzz2018-26-07-06

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Study on the association between peri-pregnancy factors and childhood autism

LI Zhun1, YANG Shao-ping2, TANG Jun3, YANG Sen-bei1, PAN Shu-ya1, JIANG Wei-wei4, ZHANG Jing1   

  1. 1 Department of Maternal and Child Health Care,School of Public Health,Tongji College of Medicine,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China;
    2 Wuhan Women and Children's Hospital,Wuhan,Hubei 430015,China;
    3 Wuhan Mental Health Center,Wuhan,Hubei 430012,China;
    4 Wuhan Xiehe Hospital, Wuhan, Hubei 430022, China;
  • Received:2018-01-16 Online:2018-07-10 Published:2018-07-10
  • Contact: ZHANG Jing,


李准1, 杨少萍2, 汤珺3, 杨森焙1, 盘舒娅1, 蒋蔚蔚4, 张静1   

  1. 1 华中科技大学同济医学院公共卫生学院儿少卫生与妇幼保健学系,湖北 武汉 430030;
    2 武汉市妇女儿童医疗保健中心,湖北 武汉 430015;
    3 武汉市精神卫生中心,湖北 武汉 430012;
    4 武汉市协和医院,湖北 武汉 430022;
  • 通讯作者: 张静,E-mail:
  • 作者简介:李准(1992-),男,江苏人,研究生,硕士学位,主要研究方向为儿童保健及健康促进。
  • 基金资助:

Abstract: Objective To explore the peri-pregnancy risk factors for childhood autism,in order to provide evidence for prevention and intervention. Methods A 1∶3 matched case-control study was used in this research.A total of 180 autistic children in two medical institutions of Wuhan were selected as case group from 2013 to 2015,and 540 healthy children in Wuhan were recruited as control group.Caregivers or parents were investigated by using self-designed Childhood Psychological and Behavioral Development and Related Factors Questionnaire.Epidata 3.1 software was used for data-entry.Statistical analysis was conducted via SPSS 24.0 software. Results Factors that may increase risk for childhood autism included maternal stress during pregnancy (OR=20.118,95%CI: 9.812~60.696),postterm pregnancy (OR=7.379,95%CI: 1.328~40.985),pregnancy diseases (OR=2.876,95%CI: 1.528~5.414),pre-pregnancy overweight/obesity (OR=2.309,95%CI: 1.184~4.501),history of adverse pregnancy outcomes (OR=1.678,95%CI: 1.056~2.665),neonatal asphyxia (OR=4.624,95%CI: 1.416~15.105),paternal age≥30 (OR=2.712,95%CI: 1.711~4.299),paternal education of junior college/undergraduate/+(OR=6.511,95%CI: 3.878~10.931). Conclusion Several peri-pregnancy factors are associated with childhood autism,positive peri-pregnancy care may reduce these factors and subsequently decrease the risk of autism.

Key words: childhood autism, peri-pregnancy, risk factors

摘要: 目的 探究围孕期相关因素与儿童孤独症的关系,为孤独症的防治提供依据。方法 选取2013-2015年武汉市两所医疗卫生机构中确诊的180例武汉市孤独症患儿,采用1∶3配对病例对照研究方法,选择与病例匹配的540例武汉市健康儿童。采用自行设计的《儿童心理行为发育及相关因素调查表》对儿童的主要监护人进行问卷调查。使用Epidata 3.1软件录入数据,利用SPSS 24.0软件对数据进行统计分析。结果 儿童孤独症与母亲孕期精神压力(OR=20.118,95%CI:9.812~60.696)、过期妊娠(OR=7.379,95%CI:1.328~40.985)、孕期患病(OR=2.876,95%CI:1.528~5.414)、孕前超重/肥胖(OR=2.309,95%CI:1.184~4.501)、不良孕产史(OR=1.678,95%CI:1.056~2.665)、新生儿窒息/缺氧(OR=4.624,95%CI:1.416~15.105)、父亲生育年龄≥30岁(OR=2.712,95%CI:1.711~4.299),父亲大专/本科及以上学历(OR=6.511,95%CI:3.878~10.931)有关。结论 围孕期的多种因素在儿童孤独症的发生发展中起到一定作用,积极做好围孕期保健,减少这些因素的发生有助于降低孤独症风险。

关键词: 儿童孤独症, 围孕期, 危险因素

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