Effect of early intervention of nerve development on longitudinal development of premature infants

doi:10.11852/zgetbjzz2018-1549

Abstract

Abstract: Objective To analyze the role of early intervention of nerve development on longitudinal development of premature infants, in order to provide evidence for improving prognosis. Methods Totally 60 premature infants born in Affiliated Hospital of Chengde Medical University were divided into intervention group and control group according to the willing of the family, and 30 full-term infants were selected as the term group from October 2014 to October 2015.The clinical data of preterm infants and their mothers were retrospectively collected.And the neurodevelopmental evaluation was performed with Gessel Development Scale at the age of 3 months old, 1 year old, 2 years old and 3 years old and the results were compared longitudinally. Results The neurobehavioral development of preterm infants in intervention group was superior to that in control group at the age of 1 year old(P<0.05), but there was no significant difference on gross motor movement development between intervention group and the term infants (P>0.05).There was no difference between the intervention group and the term infants on neurobehavioral development at 3 years old (P>0.05).But the language and the fine movement in control group still lagged behind the intervention group and term group(P<0.05).The longitudinal comparison indicated that the preterm infants in the intervention group had earlier neurodevelopmental catch-up and faster catch-up speed. Conclusion Early intervention of nerve development can improve the nerve development of premature infants as early as possible and realize the catch-up growth of nerve development.

Key words: neurobehavioral development, early intervention, Gesell Developmental Scale, preterm infants, longitudinal development

摘要： 目的分析神经发育早期干预在早产儿神经发育中的作用,为改善早产儿神经发育预后提供依据。方法 2014年10月-2015年10月以承德医学院附属医院出生60早产儿为研究对象,按照家属意愿分为干预组和对照组;抽取同期出生的30例足月儿作为足月儿组。收集一般资料及家庭资料,并在生后3个月、1岁、2岁、3岁时用Gesell发展量表行神经发育评估,并进行纵向对比。结果干预组早产儿在生后1岁时各项神经行为发育均优于对照组(P<0.05),大运动发育与足月儿差异无统计学意义(P>0.05);3岁时干预组神经发育与足月儿差异无统计学意义(P>0.05);而对照组语言、精细运动仍明显落后于干预组及足月儿组(P<0.05)。纵向比较发现,干预组早产儿神经发育追赶发生较早且追赶速度较快。结论早期进行神经发育干预能尽早改善早产儿神经发育,实现神经发育追赶生长。

关键词: 神经发育, 早期干预, Gesell发展量表, 早产儿, 纵向发育

CLC Number:

R179

LIU Li-rui, WU Yan-qiu, LIU Xia, WANG Wei-wei, XU Dong-mei, ZHOU Qi-li, MENG Lan-si, HUANG Hui-jie. Effect of early intervention of nerve development on longitudinal development of premature infants[J]. journal1, 2019, 27(4): 414-417.

刘利蕊, 武彦秋, 刘霞, 王薇薇, 胥冬梅, 周启立, 孟兰思, 黄慧洁. 神经发育早期干预在早产儿纵向发育中的应用效果[J]. 中国儿童保健杂志, 2019, 27(4): 414-417.

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