journal1 ›› 2019, Vol. 27 ›› Issue (6): 659-663.DOI: 10.11852/zgetbjzz2018-1256

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Clinical study on vitamin K1 and protein induced by vitamin K absence or antagonist-Ⅱ in neonatal umbilical cord blood

FAN Xiao-gang1, XI Sha1, WANG Ya-qin2, XIAO Mi1, CHEN Ru-juan1, WANG Fang-hui1, LIN Xiao-jie1, LIU Li1   

  1. 1 Department of Neonatology, the First Affiliated Hospital of Xi′an Jiaotong University,Xi′an,Shaanxi 710061,China;
    2 Department of Obstetrics,Shannxi Provincial People′s Hospital,Xi′an, Shaanxi 710068,China
  • Received:2018-10-11 Online:2019-06-10 Published:2019-06-10
  • Contact: LIU Li,


范小刚1, 奚莎1, 王亚琴2, 肖谧1, 陈茹娟1, 王芳会1, 林晓洁1, 刘俐1   

  1. 1西安交通大学医学院第一附属医院新生儿科, 陕西 西安 710061;
    2 陕西省人民医院妇产科, 陕西 西安 710068
  • 通讯作者: 刘俐,
  • 作者简介:范小刚(1986-),男,陕西人,在读硕士研究生,主要研究方向为新生儿疾病。

Abstract: Objectives To investigate the level of vitamin K1 (VK1)and protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ) in neonatal umbilical cord blood of different gestational age,and to discuss the influencing factors,so as to provide the basis for prevention and treatment of vitamin K deficiency hemorrhage and the application of vitamin K in clinical practice. Methods Neonates who did not have prophylactic use of vitamin K1 born in the First Affiliated Hospital of Xi′an Jiaotong University and Shaanxi People′s Hospital from December 2016 to March 2017 were enrolled in this study,and the umbilical cord blood of 100 neonates were collected by random number method.The level of VK1 was tested by high performance liquid chromatography-mass spectrometry,and the level of PIVKA-Ⅱ was tested by ELISA.Maternal history and related abnormal factors were investigated and recorded. Results The levels of VK1 and PIVKA-Ⅱin 100 neonates were (0.293±0.135) ng/ml and (22.479 ± 13.151) AU/ml.The level of VK1 was negatively related to that of PIVKA-Ⅱ(r=-0.362,P<0.001).The levels of VK1 and PIVKA-Ⅱin neonatal umbilical cord blood were significantly different on the maternal education level,residence place and the intake of green vegetables during pregnancy (P<0.05).Moreover,the amount of green vegetables intake was independently influencing factors for the levels of VK1 and PIVKA-Ⅱ (P<0.05). Conclusions Neonates have high level of VK1 and low level of PIVKA-Ⅱ in umbilical cord blood.The rate of subclinical and clinical vitamin K deficiency is higher,so it is crucial to monitor the levels of PIVKA-Ⅱand vitamin K for pregnant women and newborn infants.Increasing green vegetable intake during pregnancy and timely monitoring the levels of PIVKA-Ⅱand vitamin K for pregnant women and newborn infants,will help to prevent and find the subclinical and clinical vitamin K deficiency early.

Key words: vitamin K1, PIVKA-Ⅱ, vitamin K deficiency bleeding, influencing factors

摘要: 目的 了解不同胎龄新生儿脐血维生素K1及维生素K缺乏诱导蛋白(PIVKA-Ⅱ)水平,探讨其影响因素,为防治维生素K缺乏性出血及维生素K在临床的合理应用提供依据。方法 选择2016年12月-2017年3月在西安交通大学第一附属医院及陕西省人民医院出生,且尚未预防性注射维生素K1的新生儿,按随机数字法采集100例新生儿脐血,用高效液相质谱法检测VK1水平,用ELISA法检测PIVKA-Ⅱ水平,并记录产妇病史及相关异常因素。结果 100例新生儿脐血VK1水平为(0.293±0.135) ng/ml, PIVKA-Ⅱ水平为(22.479±13.151)AU/ml,脐血VK1水平与PIVKA-Ⅱ水平呈负相关(r=-0.362,P<0.001)。孕母不同文化程度、不同居住地以及孕期食用绿色蔬菜的多少不同,其新生儿脐血VK1水平、PIVKA-Ⅱ水平的差异有统计学意义(P<0.05),其中孕期食用绿色蔬菜的多少是新生儿脐血VK1,PIVKA-Ⅱ水平的独立影响因素(P<0.05)。结论 新生儿的脐血VK1含量较低,PIVKA-Ⅱ水平高。亚临床及临床VK缺乏率较高,围生期母儿PIVKA-Ⅱ、VK监测很有必要。提高孕母孕期绿色蔬菜摄入和孕母孕期、新生儿期PIVKA-Ⅱ、VK1的监测,有助于预防和及早发现亚临床及临床VK缺乏。

关键词: 维生素K1, PIVKA-Ⅱ, 维生素K缺乏性出血, 影响因素

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