journal1 ›› 2019, Vol. 27 ›› Issue (10): 1115-1119.DOI: 10.11852/zgetbjzz2019-0497

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Relationship between cord blood 25-hydroxyvitamin D and atopic dermatitis within 6 months after birth in infants

WANG Jing1, ZHANG Yue2, TAN Mei-zhen1, XIAO Yu-lian1, WEI Ru1, WANG Ling-hua3   

  1. 1 Department of Child Healthcare,Guangzhou Women and Children′s Medical Center,Guangzhou,Guangdong 510120,China;
    2 Institute of Pediatrics,Guangzhou Women and Children′s Medical Center,Guangzhou,Guangdong 510623,China;
    3 Department of Psychological,Guangzhou Women and Children′s Medical Center,Guangzhou,Guangdong 510120,China
  • Received:2019-04-10 Online:2019-10-10 Published:2019-10-10
  • Contact: WANG Ling-hua,


王静1, 张悦2, 谭美珍1, 肖玉联1, 韦茹1, 汪玲华3   

  1. 1 广州市妇女儿童医疗中心保健科,广东 广州 510120;
    2 广州市妇女儿童医疗中心儿科研究所,广东 广州 510623;
    3 广州市妇女儿童医疗中心心理科,广东 广州 510120
  • 通讯作者: 汪玲华,
  • 作者简介:王静(1982-),女,四川人,主治医师,硕士学位,研究方向为早期营养对婴幼儿生长发育的影响。
  • 基金资助:

Abstract: Objective To analyze the relationship between cord blood 25-hydroxyvitamin D [25-(OH)D] and infant atopic dermatitis(AD),in order to provide reference for the primary prevention and early intervention for AD in infants. Methods Totally 202 mothers and their infants were enrolled in this study from December 2016 to December 2017.Cord blood was collected at birth,and the children were followed up to 6 months old.A standard questionnaire was used to obtain the information of parents and infants,serum level of cord blood 25-(OH)D was detected by enzyme-linked immunosorbent assay.Objective Scoring of Atopic Dermatitis(SCORAD) was used to assess the severity of AD in infants.And the risk factors for AD in infants were analyzed by nested case-control study and Logistic regression analyzed. Results There was no statistically significant difference on cord blood level of 25-(OH)D between AD group and the healthy control group .Positive family history of allergy (OR=1.963),non-exclusive breastfeeding (OR=2.089),and birth in summer (OR=2.265) were risk factors for the occurrence of AD(P<0.05).Cord blood levels of 25-(OH)D was negatively correlated with the severity of AD in infants (r=-0.325,P=0.023). Conclusions Cord blood 25-(OH)D can not predict the occurrence of AD in infants,but it is negatively correlated with the severity of AD.Reasonable vitamin D supplementation during pregnancy may reduce the severity of AD in infants.

Key words: cord blood, 25-hydroxyvitamin D, atopic dermatitis, infant

摘要: 目的 分析新生儿脐血25-羟基维生素D[25-(OH)D]水平与婴儿特应性皮炎(AD)的关系,为婴儿AD的一级预防及早期干预提供依据。方法 2016年12月-2017年12月前瞻性连续选取孕期妇女及其所生婴儿202对,出生时留取脐血,跟踪至婴儿6月龄,采用标准问卷调查获取父母及婴儿资料,酶联免疫吸附试验检测脐血血清25-(OH)D水平。 通过客观的SCORAD评分评估AD患儿病情的严重程度。用巢式病例对照及Logistic回归的方法分析影响婴儿AD发生的危险因素。结果 脐血25-(OH)D水平在AD患儿及健康对照组中的差异无统计学意义,家族过敏史阳性(OR=1.963)、非纯母乳喂养(OR=2.089)、夏季出生(OR=2.265)是影响AD发生的危险因素(P<0.05)。脐血25-(OH)D水平与婴儿AD的严重程度负相关(r =-0.325,P=0.023)。结论 脐血25-(OH)D不是预测婴儿AD发生的危险因素,但与AD发生的严重程度负相关,孕期合理地补充维生素D可能会减轻婴儿AD的严重程度。

关键词: 脐血, 25-羟基维生素D, 特应性皮炎, 婴儿

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