Research progress on motor development in infants with prenatal iron deficiency

doi:10.11852/zgetbjzz2019-0158

Abstract

Abstract: Iron deficiency (ID) and iron deficiency anemia (IDA) are the most common nutrient deficiency worldwide.Pregnant women and infants are the high-risk population of ID.Maternal ID,to a certain extent,may affect fetal/neonatal iron status.ID in early life affects motor development of individual mainly through alteration of myelination,striatal and dopamine neurotransmitter system.Early postnatal iron supplementation can correct ID in circulation and tissue,but can not completely reverse the behavioral changes caused by ID during pregnancy.Therefore,it is of great significance to further study the effect of prenatal ID and its reversibility on motor development in infancy,and to clarify the critical time window of iron therapy for improving children′s quality of life and long-term prognosis.

Key words: irondeficiency, myelination, dopamineneurotransmitter, motordevelopment, infants

摘要： 铁缺乏(ID)和缺铁性贫血(IDA)是全球最常见的单一营养缺乏性疾病。孕妇和婴幼儿是ID的高危人群,孕母ID到一定程度会影响胎儿/新生儿的铁营养状况。早期ID主要通过影响髓鞘化、纹状体和多巴胺神经递质影响个体的运动发育。生后早期给予足量的铁剂治疗能纠正婴幼儿循环及组织内的ID,但无法完全逆转孕期ID所致的行为改变。深入研究孕期ID对婴幼儿运动发育的影响及其可逆性,明确铁剂治疗的关键时间窗,对提高儿童生存质量,改善远期预后具有十分重要的意义。

关键词: 铁缺乏, 髓鞘化, 多巴胺神经递质, 运动发育, 婴幼儿

CLC Number:

R174

LI Ming-yan, ZHAO Zheng-yan. Research progress on motor development in infants with prenatal iron deficiency[J]. journal1, 2019, 27(11): 1192-1195.

李明燕 , 赵正言. 孕期缺铁对婴幼儿运动发育的研究进展[J]. 中国儿童保健杂志, 2019, 27(11): 1192-1195.

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