Abstract: Objective To evaluate the association of attentional inhibition function with their attention deficit hyperactivity disorder (ADHD) behavior scores,so as to provide experimental evidence on the risk of suffering from ADHD in preschool children with purulent meningitis. Methods A total of 53 children aged 3-5 years with purulent meningitis (33 males and 20 females) from Zhengzhou Children′s Hospital and 45 controls (24 males and 21 females) from kindergarten were recruited from September 2017 to May 2018 in present study.Attentional inhibition function was measured by GO/NOGO experiment,while hyperactivity tendency was assessed by the Children′s ADHD Behavior Scale for all subjects.Pearson correlation analysis was used to explore the pairwise correlation between attentional inhibition and ADHD behavior scores. Results In the GO trial and the NOGO trial,the reaction time in purulent meningitis group was longer than that in control group[GO:(2 260.6±654.2) ms vs.(1 105.8±499.4) ms,P<0.01;NOGO:(2 220.2±693.6) ms vs.(1 017.3±454.9) ms,P<0.001].The ADHD behavior score in the purulent meningitis group was higher than that in control group[(13.1±4.1) vs.(10.9±4.6),P<0.001].According to the Pearson correlation analysis,the reaction time of NOGO trail was positively related to ADHD behavior score (r=0.320,P=0.03) in the purulent meningitis group. Conclusion Preschool children with purulent meningitis have obvious deficits in attentional inhibition,which may be related to their hyperactivity behavior.

Key words: purulent meningitis, attentional inhibition, attention deficit hyperactivity disorder, behavior checklist

摘要： 目的 分析学龄前化脓性脑膜炎患儿的注意抑制功能及与其多动症行为得分的关系,为化脓性脑膜炎患儿罹患多动症的风险提供实验依据。方法 2017年9月—2018年5月在郑州儿童医院招募3~5岁化脓性脑膜炎患儿。采用GO/NOGO实验评估53例化脓性脑膜炎儿童(男33名,女20名)和45名对照者(男24名,女21名)的注意抑制功能,并通过儿童多动症行为量表评估被试者的多动症行为得分,使用Pearson相关分析探讨注意抑制功能与多动症行为得分之间的关系。结果 在GO试次和NOGO试次中,化脓性脑膜炎组的反应时均长于对照组[GO:(2 260.6±654.2)ms vs.(1 105.8±499.4)ms,P<0.01;NOGO:(2 220.2±693.6)ms vs.(1 017.3±454.9)ms,P<0.001]。化脓性脑膜炎组的多动症行为得分高于对照组[(13.1±4.1)vs.(10.9±4.6),P<0.001]。Pearson相关分析显示,化脓性脑膜炎组的NOGO反应时与多动症行为得分呈正相关(r=0.320,P=0.03)。结论 学龄前化脓性脑膜炎儿童的注意抑制功能存在缺陷,该缺陷可能与多动倾向有关。

关键词: 化脓性脑膜炎, 注意抑制功能, 多动症, 行为量表