Systematic review on the effect of gluten-free and casein-free diets inchildren with autism spectrum disorder

doi:10.11852/zgetbjzz2021-0249

Abstract

Abstract: Objective To systematically interview the effects of gluten-free and casein-free (GFCF) diets in children with autism spectrum disorder(ASD), in order to provide scientific reference for clinical treatment. Methods Literature searches were conducted in PubMed, EBSCO, Cochrane Library, SpringerLink, Vip, Wan-fang and China National Knowledge Internet (CNKI) database. Only randomized controlled trails were included, and the quality of the literature was evaluated. Results A total of 7 studies with 181 ASD samples were included. Seven articles all studied the effects of GFCF diets on core symptoms of ASD, five articles showed that the GFCF diets could not improve the core symptoms of ASD. Two articles studied the effects of GFCF diets on gastrointestinal symptoms of ASD, but neither of them showed that GFCF diets could improve the gastrointestinal symptoms of ASD. Conclusion GFCF diets could not improve the core symptoms and gastrointestinal symptoms of ASDchildren.

Key words: autism spectrum disorder, diets, core symptoms, gastrointestinal symptoms

摘要： 目的系统评价无麸质无酪蛋白(GFCF)饮食对孤独症谱系障碍(ASD)儿童的治疗效果,为临床治疗提供科学依据。方法通过检索PubMed、EBSCO、Cochrane Library、SpringerLink、维普、万方、中国知网等数据库筛选符合标准的文献,进行文献质量评估,综合评估其治疗结果。结果共筛选出7篇符合标准的原始文献,包括181例ASD患者,7篇文献均研究了GFCF对ASD核心症状的影响,5篇文献均显示GFCF饮食治疗对ASD核心症状无改善作用;其中2篇同时研究了GFCF饮食对患儿胃肠道的影响,2篇均显示GFCF饮食对胃肠道无明显影响。结论 GFCF饮食疗法对ASD儿童核心症状、胃肠道症状无明显改善作用。

关键词: 孤独症谱系障碍, 饮食, 核心症状, 胃肠道症状

CLC Number:

R749.94

QU Ling-ling, WAN Yan-nan, CHENG Qian. Systematic review on the effect of gluten-free and casein-free diets inchildren with autism spectrum disorder[J]. Chinese Journal of Child Health Care, 2022, 30(8): 884-889.

瞿玲玲, 万燕南, 程茜. 无麸质无酪蛋白饮食对孤独症谱系障碍儿童治疗效果的系统评价[J]. 中国儿童保健杂志, 2022, 30(8): 884-889.

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