Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (8): 884-889.DOI: 10.11852/zgetbjzz2021-0249

Special Issue: 孤独症谱系障碍

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Systematic review on the effect of gluten-free and casein-free diets inchildren with autism spectrum disorder

QU Ling-ling, WAN Yan-nan, CHENG Qian   

  1. Children's Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child Development and Disorders/National Clinical Research Center for Child Health and Disorders/China International Scienceand Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China
  • Received:2021-02-23 Revised:2021-05-14 Online:2022-08-10 Published:2022-08-17
  • Contact: CHENG Qian, E-mail:


瞿玲玲, 万燕南, 程茜   

  1. 重庆医科大学附属儿童医院/儿童发育疾病研究教育部重点实验室/国家儿童健康与疾病临床医学研究中心/儿童发育重大疾病国家国际科技合作基地/儿科学重庆市重点实验室,重庆 400014
  • 通讯作者: 程茜,
  • 作者简介:瞿玲玲(1990-),女,主治医师,主要研究方向为儿童发育行为。

Abstract: Objective To systematically interview the effects of gluten-free and casein-free (GFCF) diets in children with autism spectrum disorder(ASD), in order to provide scientific reference for clinical treatment. Methods Literature searches were conducted in PubMed, EBSCO, Cochrane Library, SpringerLink, Vip, Wan-fang and China National Knowledge Internet (CNKI) database. Only randomized controlled trails were included, and the quality of the literature was evaluated. Results A total of 7 studies with 181 ASD samples were included. Seven articles all studied the effects of GFCF diets on core symptoms of ASD, five articles showed that the GFCF diets could not improve the core symptoms of ASD. Two articles studied the effects of GFCF diets on gastrointestinal symptoms of ASD, but neither of them showed that GFCF diets could improve the gastrointestinal symptoms of ASD. Conclusion GFCF diets could not improve the core symptoms and gastrointestinal symptoms of ASDchildren.

Key words: autism spectrum disorder, diets, core symptoms, gastrointestinal symptoms

摘要: 目的 系统评价无麸质无酪蛋白(GFCF)饮食对孤独症谱系障碍(ASD)儿童的治疗效果,为临床治疗提供科学依据。方法 通过检索PubMed、EBSCO、Cochrane Library、SpringerLink、维普、万方、中国知网等数据库筛选符合标准的文献,进行文献质量评估,综合评估其治疗结果。结果 共筛选出7篇符合标准的原始文献,包括181例ASD患者,7篇文献均研究了GFCF对ASD核心症状的影响,5篇文献均显示GFCF饮食治疗对ASD核心症状无改善作用;其中2篇同时研究了GFCF饮食对患儿胃肠道的影响,2篇均显示GFCF饮食对胃肠道无明显影响。结论 GFCF饮食疗法对ASD儿童核心症状、胃肠道症状无明显改善作用。

关键词: 孤独症谱系障碍, 饮食, 核心症状, 胃肠道症状

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