Abstract: Objective To test the levels of serum 25-hydroxyvitamin D₃[25-(OH)D₃] and vitamin D-binding protein (VDBP) in adolescent patients with first-episode depressive disorder, and to analyze their clinical significance. Method A total of 100 adolescent patients with first-episode depressive disorder admitted to Qinhuangdao First Hospital from April 2021 to March 2022 were selected as the depression group, and 100 healthy adolescents who took physical examinations during the same period were selected as the control group. The levels of serum 25-(OH)D₃ and VDBP were detected by enzyme-linked immunosorbent assay. Hamilton Depression Scale (HAMD) was used to assess the degree of depression in patients with depression, and then the adolescents were divided into mild group (n=41), moderate group (n=32) and severe group (n=27). The levels of serum 25-(OH)D₃ and VDBP among depression group, control group and adolescent patients with first-episode depressive disorder with different degrees of depression were compared. The correlation of serum 25-(OH)D₃ and VDBP levels with HAMD score in adolescent patients with first-episode depressive disorder and the influencing factors of the occurrence of first-episode depressive disorder were analyzed. Results Compared with the control group, the level of serum 25-(OH)D₃ in the depression group decreased (t=10.625, P<0.05), while the level of VDBP increased (t=13.158, P<0.05). The level of serum 25-(OH)D₃ of children in mild, moderate and severe depression group decreased in turn (t=58.319, P<0.05), while the level of VDBP increased in turn (F=18.805, P<0.05). Serum 25-(OH)D₃ level was negatively correlated with HAMD score and VDBP in adolescent patients with first-episode depressive disorder (r=-0.517, -0.511, P<0.05), while serum VDBP level was positively correlated with HAMD score (r=0.498, P<0.05). Serum 25-(OH)D₃ deficiency(OR=1.775) and high level of VDBP (OR=1.519) were risk factors for the occurrence of first-episode depressive disorder (P<0.05). Conclusions The serum 25-(OH)D₃ level is lower in the adolescent patients with first-episode depressive disorder, and the VDBP level is higher.Serum 25-(OH)D₃level is negatively correlated with VDBP, both of which were significantly correlated with HAMD scores. Both VDBP and 25-(OH)D₃ can be used as auxiliary indicators to determine the severity of adolescent depression.

Key words: adolescent patients with first-episode depressive disorder, 25-(OH)D₃ , vitamin D-binding protein, Hamilton Depression Scale

摘要： 目的 检测青少年抑郁症首发患者血清25-羟基维生素D₃[25-(OH)D₃]、维生素D结合蛋白(VDBP)水平,并分析其临床意义。方法 选取2021年4月—2022年3月秦皇岛市第一医院收治的100例青少年抑郁症首发患者为抑郁症组,并选取同期100例体检健康青少年为对照组。酶联免疫吸附法检测血清25-(OH)D₃、VDBP水平;汉密尔顿抑郁量表(HAMD)评定抑郁症患者抑郁程度,分为轻度组(n=41)、中度组(n=32)、重度组(n=27);比较抑郁症组和对照组、不同抑郁程度青少年抑郁症首发患者血清25-(OH)D₃、VDBP水平;分析青少年抑郁症首发患者血清25-(OH)D₃、VDBP水平与HAMD评分的相关性及首发青少年抑郁症发生的影响因素。结果 与对照组相比,抑郁症组患者血清25-(OH)D₃水平降低(t=10.625,P<0.05),VDBP水平升高(t=13.158,P<0.05);轻、中、重度首发青少年抑郁症患者血清25-(OH)D₃水平依次降低(F=58.319,P<0.05),VDBP水平依次升高(F=18.805,P<0.05);青少年抑郁症首发患者血清25-(OH)D₃水平与HAMD评分、VDBP呈负相关(r=-0.517、-0.511,P<0.05),血清VDBP水平与HAMD评分呈正相关(r=0.498,P<0.05);血清25-(OH)D₃缺乏(OR=1.775)、VDBP高水平(OR=1.519)是影响首发青少年抑郁症发生的危险因素(P<0.05)。结论 青少年抑郁症首发患者血清25-(OH)D₃水平较低,VDBP水平较高,25-(OH)D₃与VDBP呈负相关,且均与HAMD评分显著相关,VDBP、25-(OH)D₃可作为判定青少年抑郁症患者病情严重程度的辅助指标。

关键词: 首发青少年抑郁症, 25-羟基维生素D₃, 维生素D结合蛋白, 汉密尔顿抑郁量表