Abstract: 【Objective】 To probe the effects of IL-8,IL-10 and NF-kB about qingrejieduliangxuefang combined with montmorillonite powder to infectious diarrheal children. 【Methods】 All 162 outpatients and inpatients suffered with infectious diarrhea were enrolled randomly, but during the study,12 cases were exited because of uninsistence.So 150 cases were given to viral enteritis group and bacterial enteritis group,8 normal children were as normal group and the expression of related factors of pre-treated and post-treated were tested.Children were randomly divided into treated Ⅰgroup,treatedⅡgroup,and control group according to treated programs. Retention enema of qingrejieduliangxuefang was given to treatedⅠgroup,and combined with montmorillonite powder to treatedⅡgroup,montmorillonite powder was given to control group.The changes of related factors of pre-treated and post-treated for 5 days and 15 days were tested. 【Results】 Pre-treated,the IL-8 level was without significant difference(P>0.05) in bacterial enteritis and viral enteritis group.The IL-10 level of bacterial enteritis group was lower than that of viral enteritis group(P＜0.01).Pre-treated,the level of IL-8,IL-10 and NF-kB was without significant difference(P>0.05) in treatedⅠgroup,treatedⅡgroup,and control group.At the end of 5 days and 15 days,compared with oneself pre-treated,the expression of each group reduced signally(P＜0.01)and the level of treated Ⅱgroup was superior to treatedⅠgroup and control group(P＜0.05). 【Conclusions】 IL-10 is helpful to indentify bacterial enteritis and viral enteritis.Qingrejieduliangxuefang combined with montmorillonite powder is good to reduce the expression of related factors and promote a speedy recovery of infectious diarrheal children.

Key words: qingrejieduliangxuefang, infectious diarrhea, IL-8, IL-10, NF-kB

摘要： 【目的】 探讨清热解毒凉血方联合蒙脱石散对感染性腹泻患儿相关因子白介素8(IL-8)、白介素10(IL-10)、单核细胞核因子(NF-kB)表达的影响。 【方法】 随机选门诊及病房的感染性腹泻患儿162例,治疗过程中因未能坚持退出12例,最终入选150例。将150名感染性腹泻患儿按感染类型分为病毒性肠炎组和细菌性肠炎组,并随机选8名正常儿童作为正常组,观察各组治疗前相关因子的表达。并将患儿按治疗方案不同随机分为治疗Ⅰ组、治疗Ⅱ组和对照组。治疗Ⅰ组采用清热解毒凉血方灌肠;治疗Ⅱ组在治疗1组的基础上口服蒙脱石散;对照组仅口服蒙脱石散。观察治疗5 d、15 d前后相关因子的变化。 【结果】 治疗前细菌性肠炎组IL-8含量与病毒性肠炎组相比差异无统计学意义(P＞0.05);细菌性肠炎组IL-10低于病毒性肠炎组(P＜0.01)。治疗前治疗Ⅰ组、治疗Ⅱ组、对照组三组IL-8、IL-10 、NF-kB相比差异无统计学意义(P＞0.05),治疗5 d、15 d后各自与治疗前相比均明显降低(P＜0.01);治疗Ⅱ组优于治疗Ⅰ组及对照组(P＜0.05)。 【结论】 IL-10可作为鉴别细菌性或病毒性肠炎的辅助诊断方法;清热解毒凉血方联合蒙脱石散能明显降低感染性腹泻患儿相关因子的表达,促进患儿早日康复。

关键词: 清热解毒凉血方, 感染性腹泻, IL-8, IL-10, 单核细胞核因子