金荞麦抑瘤活性成份提取及作用机制研究进展

doi:10.12092/j.issn.1009-2501.2019.07.018

中国临床药理学与治疗学 ›› 2019, Vol. 24 ›› Issue (7): 833-840.doi: 10.12092/j.issn.1009-2501.2019.07.018

• 综述与讲座 • 上一篇

金荞麦抑瘤活性成份提取及作用机制研究进展

李红丽1,2，文丹丹1，周美亮3，王海华2，彭喜旭2，高利臣1,2

¹南华大学附属长沙中心医院药学部，长沙市肿瘤研究所，Ⅰ期临床研究中心，长沙 410004，湖南；²湖南科技大学生命科学学院，湘潭 411201，湖南；³中国农业科学院作物科学研究所，北京 100081，北京

收稿日期:2019-05-07 修回日期:2019-05-10 出版日期:2019-07-26 发布日期:2019-07-29
通讯作者: 彭喜旭，副教授，研究方向：药理学。 Tel: 0731-58291416 E-mail: xxpeng@hnust.edu.cn 高利臣，男，副主任药师，研究方向: 临床药理学与药物基因组学。 Tel: 0731-85667812 E-mail: gonedog1224@hotmail.com
作者简介:李红丽，女，硕士研究生，研究方向：药理学与药效学。 Tel: 0731-85667812 E-mail: 1440210768@qq.com 文丹丹，女，硕士研究生，研究方向：临床药学。 Tel: 0731-85667812 E-mail: 527357433@qq.com
基金资助:
湖南省科技重点研发计划（2016SK2066）；湖南省中医药科研计划（201940）；长沙市科技计划（kq1801144）；南华大学附属长沙中心医院科研重点项目（YNKY201901）；湖南省高层次卫生人才“225”工程项目

Advances in extraction and mechanism of antitumor active components from Fagopyrum dibotrys

LI Hongli ^1,2, WEN Dandan ¹, ZHOU Meiliang³, WANG Haihua ², PENG Xixu ², GAO Lichen^1,2

¹ Department of Pharmacy, Cancer Institute, PhaseⅠClinical Trial Centre, Changsha Central Hospital Affiliated to University of South China, Changsha 410004, Hunan, China; ² School of Life Science, Hunan University of Science and Technology, Xiangtan 411201, Hunan, China；³ Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China

Received:2019-05-07 Revised:2019-05-10 Online:2019-07-26 Published:2019-07-29

摘要/Abstract

摘要：

金荞麦是药典收藏蓼科荞麦属药用植物，种质资源主要分布于我国中部和西南地区，其抑瘤活性成份浸滞法提取工艺滞后，主要抑瘤活性成份黄酮和酚类集中分布在根茎部位。金荞麦抗肿瘤主要机制是抑制肿瘤细胞增殖和迁移，诱导肿瘤细胞凋亡和自噬，以及抗炎抗氧化作用。本文综述了金荞麦抑瘤活性成份及提取和抗肿瘤作用机制研究进展，旨在为金荞麦抗肿瘤活性成份作用机制进一步研究和药用资源充分利用提供参考。

关键词: 金荞麦, 抑瘤成份, 成份提取, 抑瘤机制

Abstract:

Fagopyrum dibotrys is a medicinal plant of Buckwheat in Polygonaceae collected in Pharmacopoeia. It is widely distributed in the central and southwest of China. The extraction process of its antitumor active ingredients by immersion method is lagging behind. The main antitumor active ingredients, flavonoids and phenols, are concentrated in the rhizome. The main antitumor mechanisms of buckwheat are inhibiting the proliferation and migration of tumor cells, besides, inducing apoptosis and autophagy of cancer cells. In this paper, we reviewed the research progress on the antitumor chemical components, the extraction of active ingredients and the antitumor mechanisms of Fagopyrum dibotrys in order to provide references for further research on antitumor active ingredients and antitumor effects of Fagopyrum dibotrys.

Key words: Fagopyrum dibotrys, antitumor components, extraction of active ingredients, antitumor mechanisms

中图分类号:

R285

李红丽，文丹丹，周美亮，王海华，彭喜旭，高利臣. 金荞麦抑瘤活性成份提取及作用机制研究进展[J]. 中国临床药理学与治疗学, 2019, 24(7): 833-840.

LI Hongli, WEN Dandan, ZHOU Meiliang, WANG Haihua, PENG Xixu, GAO Lichen. Advances in extraction and mechanism of antitumor active components from Fagopyrum dibotrys[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(7): 833-840.

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金荞麦抑瘤活性成份提取及作用机制研究进展

Advances in extraction and mechanism of antitumor active components from Fagopyrum dibotrys

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