关键词: 白色念珠菌, 大蒜素, 巨噬细胞, IL- 12, NO

Abstract: AIM: To study the effect of allicin on macrophage of immunosuppressed mice infected by candida albicans.METHODS: The mice were randomly divided into preventive group, treatment group and infection group. Three days before the experiment, cyclophosphamide(CY) was given to the mice only once via abdominal cavity with a dosage of 200 mg/kg. The preventive group mice were fed with allicin for 7 days, the other two groups were fed with normal saline; Followed, the solution of candida albicans was administered intravenously to the mice via lateral tail vein with the concentration of 2 ×10⁷/mL in the 8th day. At the same time, the preventive group and the treatment group were fed with allicin for 7 days, the infection group were fed with normal saline; 7 days later, the mice peritoneal macrophages of the three groups were collected.The cultural liquid of macrophages was prepared and the levels of NO and IL-12 were measured.RESULTS: Compared with the infective group, allicin could improve the levels of NO and IL-12 produced by the macrophage in abdominal cavity of mice in the preventive group and the treatment group.CONCLUSION: Allicin can improve the funetion of macrophage in the model mice infected by candida albicans.

Key words: Candid albicans, Allicin, Macrophage, IL-12, NO