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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2007, Vol. 12 ›› Issue (4): 465-469.

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Clinical trial report of two doses of pemirolast potassium

XU Qin-e1, LIN Zi-ping1, LI Ze-qing2, YU Ying-ying3, MA Wei-yang4, YUE Zhi-yong5, SHI Li6, XUE Wei-guo7, ZHAO Jun1, CHAI Yi1, YU Hao8, ZHANG Yin-di8, SHEN Jian-ping8   

  1. 1Drug Research Agency and Department of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, 2Department of Otorhinolaryngology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu, China;
    3Department of Otorhinolaryngology, Zhejiang First Hospital, 4Department of Otorhinolaryngology, Second Affiliated Hospital of ZhejiangUniversity College of Medicine, Hangzhou 310000, Zhejiang, China;
    5Department of Otorhinolaryngology, Shandong Provincial Hospital, 6Department of Otorhinolaryngology, Qilu Hospital, Jinan 250000, Shandong, China;
    7Department of Otorhinolaryngology, Qingdao Hospital, Qingdao 266000, Shandong, China;
    8Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2006-06-20 Revised:2006-06-20 Published:2020-10-30

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Abstract: AIM: Using 100 mg tranilast as control, to investigate the clinical safety and effect of 5 mg or 10 mg pemirolast potassium which is for the treatment of allergic rhinitis. METHODS: Patients in the trial groups took pemirolast potassium 5 mg or 10 mg orally after breakfast and supper daily for 4 weeks.Patients in control group took tranilast 100 mg, and the usage and course of treatment were the same as trial groups.20 male volunteers took pemirolast potassium 10 mg once a day. RESULTS: Pemirolast potassium 5mg had a better effect for treatment of allergic rhinitis than tranilast 100 mg (P< 0.01).Pemirolast potassium 5 mg had a similar curative effect for allergic rhinitis to tranilast 100 mg.No serious drug reaction happened, and two doses of pemirolast potassium and tranilast 100 mg showed similar safety (P > 0.05). CONCLUSION: To cure allergic rhinitis, two doses of pemirolast potassium have good efficancy and safety compared to tranilast 100 mg.

Key words: double-simulate, rate of clinical control, pemirolast potassium, tranilast

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