Most Down Articles

Published in last 1 year | In last 2 years| In last 3 years| All| Most Downloaded in Recent Month | Most Downloaded in Recent Year|

All

Please wait a minute...


For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails

Select

Treatment of sleep disorder in patients with acute cerebrovascular disease HUANG Yaqin, XUE Rong Chinese Journal of Clinical Pharmacology and Therapeutics    2021, 26 (5): 516-521.   DOI: 10.12092/j.issn.1009-2501.2021.05.007 Abstract （737）      PDF （351KB）（11449）       Knowledge map    Save The high incidence of cerebrovascular disease and the high rate of disability cause a huge burden on the patient, family and society. The incidence of sleep disorder in acute cerebrovascular disease is high, which has an important effect on the prognosis of patients with cerebrovascular disease. This paper reviews the treatment of sleep disorder in patients with acute cerebrovascular disease, mainly acute ischemic cerebrovascular disease.  Related Articles | Metrics

Select

Chinese Journal of Clinical Pharmacology and Therapeutics    2023, 28 (4): 477-.   Abstract （157）      PDF （263KB）（8817）       Knowledge map    Save Related Articles | Metrics

Select

Progression of sulodexide and clinical application WANG Ya-min Chinese Journal of Clinical Pharmacology and Therapeutics    2010, 15 (1): 109-115.   Abstract （483）      PDF （242KB）（7936）       Knowledge map    Save Sulodexide is a new type of natural glycosaminogly cans, contains two main components to different synergistic action principle, with anticoagulation, thrombolysis, ant i-cardiovascular disease, reducing blood lipid, protecting the kidneys and other role, In recent years, in the treatment of cardio vascular disease, peripheral artery disease, post-phlebitis syndrome, complications of diabetes, especially diabetic nephropathy, etc.The clinical application attracted attention, this article on its chemical composition, pharmacokinetics, biological activity,quality control, mechanism and pharmacology, clinical research and applications, and recent research are reviewed.To be compared with similar drugs heparin, sulode xide to special due to be taken orally, the bioavailability of high, fewer side effects, and with heparin no role of the decomposition of fat can be considered more widely applied.Currently only the imported products, domestic manufacturers are in research and development stage, Ibelieve that in the near future will be made to sulodexide in china. Reference | Related Articles | Metrics

Select

Progress in clinical application of topical anesthesia TAO Yijia, YANG Chun, LIU Cunming Chinese Journal of Clinical Pharmacology and Therapeutics    2023, 28 (5): 594-600.   DOI: 10.12092/j.issn.1009-2501.2023.05.015 Abstract （542）      PDF （614KB）（5941）       Knowledge map    Save Topical anesthesia are being widely used in clinical diagnostic or therapeutic fields such as ophthalmology, ENT, dermatology, urology. It is defined as superficial loss of sensation in mucous membranes or skin, produced by direct application of penetrating local anesthetics. Topical anesthesia has the advantages of simple performance, high safety, quick recovery, which can effectively improve patient's satisfaction. In recent years, more and more attention has been paid to the concept of comfortable diagnosis and treatment. The new drugs and application methods of topical anesthesia are emerging constantly, special attention must be paid to their pharmacological characteristics and possible adverse reactions when using them. This article reviews the research progress of topical anesthesia in clinical application in order to provide reference for clinical practice. Related Articles | Metrics

Select

Dose conversion among different animals and healthy volunteers in pharmacological study HUANG Ji-Han,HUANG Xiao-Hui, CHEN Zhi-Yang, ZHENG Qing-Shan, SUN Rui-Yuan Chinese Journal of Clinical Pharmacology and Therapeutics    2004, 9 (9): 1069-1072.   Abstract （1660）      PDF （152KB）（5502）       Knowledge map    Save In order to obtain equivalent dose, a dose conversion was important among different animals and healthy volunteers in preclinical pharmacology and I phase clinical trials. Body coefficient and standard weight were introduced into the formula to estimate the equivalent dose in this paper. Reference | Related Articles | Metrics

Select

Analysis of metabolomic data: principal component analysis Jiye Aa Chinese Journal of Clinical Pharmacology and Therapeutics    2010, 15 (5): 481-489.   Abstract （1257）      PDF （913KB）（5200）       Knowledge map    Save Metabolomics has been widely applied to life science and showing a promising perspective. Conventional statistic analysis is not applicable to the large, multivariate dataset generated by high-throughput metabolomic tool, while it's of crucial importance to analyze and interpret the dataset. This article reviews the basic methods of principal components analysis(PCA) that is popular in metabolomics study, aiming at strengthening the fundamental knowledge of PCA and standardizing the methods and procedures for data analysis. Reference | Related Articles | Metrics

Select

Progress in research and evaluation on drug-plasma protein binding in pharmacology GUO Bin, LI Chuan Chinese Journal of Clinical Pharmacology and Therapeutics    2005, 10 (3): 241-253.   Abstract （730）      PDF （406KB）（4476）       Knowledge map    Save Drug-protein binding changes involved in numerous factors in vivo may cause changes of pharmacokinetic parameters.The tendency gained from large numbers of articles overemphasized the clinical importance of these changes.However, theoretic analysis and review of available literature data indicated that changes in plasma protein binding are usually of no principle pharmacodynamic implication.And they have little effect on the clinical exposure of a patient to a drug in a practical sense. The progress is reviewed in research and current opinions on drug-plasma protein binding in pharmacological basis for pharmacokinetic consequence and clinical relevance in this article. Reference | Related Articles | Metrics

Select

Influence of Astragalus membranceus and mung bean on arsenolite-induced rats LI Dong-ming, YI Zhen-nan, LIANG Biao Chinese Journal of Clinical Pharmacology and Therapeutics    2005, 10 (2): 222-225.   Abstract （173）      PDF （178KB）（4397）       Knowledge map    Save AIM: To investigate the effects of oral administration of Astragalus membranceus, mung bean and arsenolite on the toxic of the arsenolite-induced rats and the possible mechanisms with metallothionein (MT). METHODS: All the rats were oral administration with arsenolite.The Astragalus membranceus and mung bean were compared with the cadmium chloride which induced MT synthesis.The contents of MT were determined by cadmium saturation method, the liver mRNA levels for MT1, MT2 were detected by RT-PCR.The protective effects of renal and liver were observed by testing alanine aminotransferase (ALT), blood urea nitrogen (BUN) and serum creatinine (SCR).RESULTS: The contents of MT were accorded with the mRNA expression of MT1, MT2.Arsenolite, Astragalus membranceus and mung bean could induce the synthesis of MT, but the contents of MT which arsenolite induced were trace.The contents of MT significantly increased after oral administration of Astragalus membranceus and mung bean, especially in the Astragalus membranceus group (P<0.05).CONCLUSIONS: Astragalus membranccus and mung bean has a significantly inference in the MT and an antagonistic action on arsenolite-induced rats. Reference | Related Articles | Metrics

Select

Chinese Journal of Clinical Pharmacology and Therapeutics    2000, 5 (2): 162-163.   Abstract （155）      PDF （74KB）（4247）       Knowledge map    Save Reference | Related Articles | Metrics

Select

Research progress in the treatment of depression with monome of Chinese herb, drug pairs, compound prescriptions and Chinese patent drugs CHEN Ying, YUAN Yonggui Chinese Journal of Clinical Pharmacology and Therapeutics    2021, 26 (5): 586-593.   DOI: 10.12092/j.issn.1009-2501.2021.05.016 Abstract （1704）      PDF （536KB）（4228）       Knowledge map    Save Depression is a relatively common psychosomatic disease in clinical practice. It is mainly characterized by significant and lasting depression. It generally manifests as depression, loss of interest, impaired cognitive function, etc. Some patients are accompanied by somatization symptoms such as insomnia or lethargy, Loss of appetite, fatigue, loss of libido, etc. In severe cases, self-injury or even suicide may occur. According to research, depression has become the third leading cause of disability and death. At present, the pathogenesis of depression has not been definitively concluded, but a large number of studies have shown that it is related to biochemical, neuroendocrine, and neuroimmunological factors. At present, selective 5-HT reuptake inhibitors are routinely used in clinical treatment, such as sertraline, citalopram, Prozac, etc., but they often have slow onset and obvious side effects, making it difficult to achieve satisfactory therapeutic effects. Traditional Chinese medicine has gradually begun to be accepted by doctors and patients in the treatment of refractory diseases due to its multi-component and multi-target characteristics. This article mainly discusses the research progress of Chinese herbal extracts, Chinese herbal medicine pairs, Chinese herbal compound prescriptions, and Chinese patent medicines in the treatment of depression, and provides references for the clinical application of Chinese medicines in the treatment of depression. Related Articles | Metrics

Select

Research advance on the characteristics and application of CYP450 metabolic enzymes LI Xiao-yu, LIU Gao-lin Chinese Journal of Clinical Pharmacology and Therapeutics    2008, 13 (8): 942-946.   Abstract （512）      PDF （177KB）（3995）       Knowledge map    Save Cytochrome P450 is an important kind of enzymes for the metabolism of drug and other endoor xeno-biotics.Classification of metabolic enzymes, molecular biological characteristic of CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP2E1, CYP1A2 and CYP2A6were described in this review.Influence of traditional Chinese medicine (TCM)on metabolic enzyme and its application in clinical drug therapeutics and drug development were also reviewed in this article. Reference | Related Articles | Metrics

Select

Research development between JNK pathway and apoptosis WEI Na, HE Hai-bo, ZHANG Chang-cheng, YUAN Ding, WANG Ting Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (7): 807-812.   Abstract （970）      PDF （261KB）（3594）       Knowledge map    Save JNK pathway is closely associated with cell differentiation, apoptosis, stress response and many hunman diseases in the past 20 years, whose biochemical function, regulation under cell physiology and pathology are constantly noticed by domestic and foreign scholars. Recently, more research suggests that it plays an important role in regulating apoptosis, and it will be an important potential target for treatment of apoptosis-associated disease by regulating JNK signal pathway. In summary, the physiological and pathophysiological functions of JNK pathway and relation with apoptosis have been reviewed. Reference | Related Articles | Metrics

Select

Chinese Journal of Clinical Pharmacology and Therapeutics    2001, 6 (2): 97-102.   Abstract （262）      PDF （195KB）（3551）       Knowledge map    Save Related Articles | Metrics

Select

Progress in research of phase Ⅱ metabolisms and their enzymes SHI Shu-ya, WANG Lian-sheng Chinese Journal of Clinical Pharmacology and Therapeutics    2014, 19 (1): 82-89.   Abstract （765）      PDF （326KB）（3436）       Knowledge map    Save Phase Ⅱ drug-metabolizing reaction, characterized by the conjugation reaction, is an important way of body drug disposition. Glucuronidation, acetylation, methylation, glutathione conjugation reaction, and sulphation represent different conjugation reactions and are catalyzed by some similar genes or gene superfamily respectively. All these phase Ⅱ metabolic reactions have their own different characteristics and functional significance. Drug induced significant change of phase Ⅱ drug metabolizing enzyme activity may lead to clinical drug interactions. The genetic polymorphisms of phase Ⅱdrug metabolizing enzymes will affect the metabolism of endogenous substances, which may lead to the increased incidence of certain diseases, and these polymorphisms also affect the metabolism of exogenous substances, causing toxicity or changes in drug efficacy. Reference | Related Articles | Metrics

Select

Clinical evaluation of efficacy of fluticasone propionate/salmeterol in treatment of mild to moderate asthma XIA Qing, DAI Xing-ling, WANG Ru-tao Chinese Journal of Clinical Pharmacology and Therapeutics    2006, 11 (6): 702-705.   Abstract （142）      PDF （179KB）（3431）       Knowledge map    Save AIM: To evaluate clinical efficacy and safety of seretide in the treatment of patients with mild to moderate asthma.Methods: This was an opened, self-comparison study.43 patients with mild to moderate asthma were given seretide 50 250 μg inhalation twice daily via accuhaler for 20 weeks.The levels of symptoms and signs before and after therapeutics were recorded as the quality of life.The peak expiratory flow (PEF), forced expiratory volume in one second(FEV1), peak expiratory flow rate(PEFR), forced vital capacity(FVC) and symptomless time were detected.Results: The treatment with seretide resulted in remarkably improvement in efficacy variables of morning and evening PEF, asthma symptom scores.FEV1 and FVC were notably increased after 1 week of treatment and during the treatment period (P<0.01).At the end of 20 weeks treatment, asthma quality of life scores were improved significantly (P<0.01).The amount of asymptomatic day of patients with mild to moderate asthma were increased.There were 39 patients achieving the criteria for well-controlled.Only 1 patient had hoarseness.Conclusion: Seretide possesses the advantage of effectiveness, safety and well tolerance in patients with mild to moderate asthma. Reference | Related Articles | Metrics

Select

Progresses in studies on pharmacologic effects of ginsenosides WANG Hai-nan Chinese Journal of Clinical Pharmacology and Therapeutics    2006, 11 (11): 1201-1206.   Abstract （1090）      PDF （214KB）（3421）       Knowledge map    Save Ginsenosides are major active ingredients of ginseng.The Pharmacologic effects of ginsenosides are various.The pharmacologic effects of individual ginsenoside have been studied deeply now, especially focusing on regulation of metabolism.In this article, we reviewed progresses in studies on pharmacologic effects of ginsenosides in recent years in the world, referring to nervous system, small intestinal transit, endocrine system, immune system, signal transduction, anti-aging, hemolysis,burn wound healing, synergy of anti-tumor, human sperm motility, drug metabolism enzyme and lowering plasma glucose.Furthermore, protopanaxadiol-type ginsenosides were compared with protopanaxatriol-type ginsenosides on the pharmacologic effects briefly. Reference | Related Articles | Metrics

Select

Discussions in pharmacological action and the development in clinical application of puer arin YAO Dan, DING Xuan-sheng Chinese Journal of Clinical Pharmacology and Therapeutics    2008, 13 (4): 468-474.   Abstract （586）      PDF （237KB）（3377）       Knowledge map    Save As a saft and effective traditional Chinese medicine’s parenteral in jection, puerarin, whose molecular formula is 4,7-dihydroxy- 8β-D glucose isoflavone, has comprehensive and extensive phammaco logical action, and is generally used for treatment of cardiovascu lar and cerebrov ascular system diseases such as arhythmia, myocardial ischemia and hypertension.It has an extensive deve lopment perspective. The recent research in the mechanism of phamacological action and clinical application W ere review ed. Reference | Related Articles | Metrics

Select

Study on pharmacokinetics of rosuvastatin and its drug interactions with other drugs WEN Jin-hua, XIONG Yu-qing Chinese Journal of Clinical Pharmacology and Therapeutics    2011, 16 (11): 1309-1314.   Abstract （780）      PDF （261KB）（3244）       Knowledge map    Save Rosuvastatin, a new generation of statins , has better liver selectivity, less metabolism and long elimination half-life.It has more lipid-lowering effect and a wide range prospects of clinical applications. Moreover, rosuvastatin has good tolerability and the incidence of adverse reactions was similar to other kind of statins. In this paper, rosuvastatin pharmacokinetics and pharmacokinetic interactions with other drugs are reviewed. In order to lay down a solid theory foundation for the guidance in clinical usage of Rosuvastatin, ensure the safety and effectiveness of clinical usage, achieving individualized therapy in its true sense. Reference | Related Articles | Metrics

Select

Recent advancement in pharmacological effects of artemisinin and its derivatives GUO Yan, WANG Jun, CHEN Zheng-tang Chinese Journal of Clinical Pharmacology and Therapeutics    2006, 11 (6): 615-620.   Abstract （280）      PDF （207KB）（3210）       Knowledge map    Save Artemisinin, an active compound extracted from Artemisia annua, L.together with its derivatives are widely used as anti-malarial drugs.In recent years, artemisinin and many of its analogs were reported to possess some other effects such as anti-inflammatory, immuno-modulation and antitumor activities besides antiparasitic actions against Plasmodium falciparum and Schistosoma.Based on an introduction of the conventional actions and mechanisms of these drugs, we reviewed the recent progress of their new biological actions in this article. Reference | Related Articles | Metrics

Select

Current status of clinical drug-drug interactions research of innovative small molecule drugs in China LIU Lu, CHEN Xiaoyan Chinese Journal of Clinical Pharmacology and Therapeutics    2021, 26 (8): 863-875.   DOI: 10.12092/j.issn.1009-2501.2021.08.003 Abstract （765）      PDF （629KB）（3210）       Knowledge map    Save In order to improve the efficacy or reduce the side effects, the combination of two or more drugs is often used in clinical practice, which often brings new medication problems that change the process or efficacy of a drug in vivo due to combination. This article reviews the clinical drug-drug interaction (DDI) researches of 44 novel molecular entities which were approved to be launched in China from January 2000 to March 2021. Among them, clinical DDI trials based on test drugs as substrates of the metabolic enzymes (11/44) especially as the substrates of CYP3A4 (7/11) are dominant. The results show that most of test drugs were CYP3A4 substrates with a moderate or lower sensitivity, and no highly sensitive substrates were found. The second is the clinical DDI trials based on synergy or reducing side effects, which mainly focus on the fields of tumors, diabetes, and viral infections, and these studies have not shown pharmacokinetic interactions with clinical significance. The DDI trials of test drugs as metabolic enzyme modulators account for 7/44. And transporter-based DDI trials are relatively rare and most of them are in vitro studies. With the in-depth study of drug metabolism/transport mechanisms in vivo and in vitro, especially the development of clinical trials of radioisotope-labeled drugs and computer simulations, the overall level of DDI research in China is gradually improving, which will provide a solid scientific foundation to ensure drug safety. Related Articles | Metrics

Select

Sample size estimation in randomized controlled drug clinical trials LI Chan-juan, JIANG Zhi-wei, WANG Rui, XIA Jie-lai Chinese Journal of Clinical Pharmacology and Therapeutics    2011, 16 (10): 1132-1136.   Abstract （931）      PDF （223KB）（3209）       Knowledge map    Save Sample size estimation is a key research aspect in randomized controlled drug clinical trial. Sample size estimation factors, parameters and basic rules are discussed in our research. In addition, sample size estimation procedures are introduced based on two examples. A reference is provided for estimating sample size in randomized controlled clinical trials. Reference | Related Articles | Metrics

Select

Chinese Journal of Clinical Pharmacology and Therapeutics    2016, 21 (2): 218-224.   Abstract （1604）      PDF （3257KB）（3101）       Knowledge map    Save Related Articles | Metrics

Select

Preclinical pharmacology research of oxiracetam JIN Lei, LI Bo, YE Lei, CAI Yun-Hong, RONG Zu-Yuan Chinese Journal of Clinical Pharmacology and Therapeutics    2011, 16 (3): 354-360.   Abstract （727）      PDF （267KB）（3072）       Knowledge map    Save It has been more than 20 years since the birth of nootropic drug oxiracetam, extensive and deep research has been focused on its pharmacological features in china and abroad. As a general pharmacologically inactive and non-toxic cognition enhancer, it possesses good pharmacokinetics characteristics. The pharmacological effects of oxiracetam include the improvement of learning and memory and neuroprotective function. The mechanism of its action may involve: the effect on central acetylcholine system and the interaction between other neurotransmitter systems associated with cognition (such as glutamate system, monoamine neurotransmitter system) and the cholinergic system, induction and maintenance of LTP, activation of protein kinase C, promotion of brain metabolism, the impact of peripheral steroid hormones, etc. Reference | Related Articles | Metrics

Select

Advances in study of estrogen and its receptors signal transduction pathway FAN Guan-wei, HE Jun, WANG Hong, GAO Xiu-mei Chinese Journal of Clinical Pharmacology and Therapeutics    2007, 12 (3): 266-269.   Abstract （454）      PDF （155KB）（2977）       Knowledge map    Save Estrogen gradually becomes the research hot spot because it has extensive biological effect, which exerts its function by binding to estrogen receptors (ERs).ERs have the widespread organization distribution, including the reproductive system, the skeleton and the cardiovascular system, and these provided the guarantee for the estrogen to display biology effect.This article reviews the advance of estrogen and its receptors signal transduction pathway in abroad and domestic. Reference | Related Articles | Metrics

Select

Progress on the pathological mechanism and treatment of frostbite  ZHANG Li, LIN Xingyao, SHANG Yun, WANG Qiang Chinese Journal of Clinical Pharmacology and Therapeutics    2023, 28 (3): 347-354.   DOI: 10.12092/j.issn.1009-2501.2023.03.014 Abstract （784）      PDF （808KB）（2951）       Knowledge map    Save Frostbite is a tissue injury that occurs when the body is exposed to extreme cold. Its path-ological mechanism is complex and has not been ful-ly elucidated. In high cold and high altitude areas, outdoor sports people have a high risk of injury, and severe frostbite has high disability and mortality. Ex-ploring the pathological mechanism of frostbite is helpful to determine the treatment methods and timing. At present, the clinical treatment of frostbite is mainly symptomatic treatment, such as drug treatment and surgical treatment, but the curative effect can not meet the clinical needs. Therefore, it is of great significance to seek more efficient drugs or treatment methods. This article reviews the rele-vant research progress in pathophysiological mecha-nism, clinical treatment, cellular and molecular path-ways of frostbite in recent years, in order to provide new ideas for future research and clinical treatment.  Related Articles | Metrics

Select

Research advances in models of hepatic and intestinal first-pass drug metabolism ZHU Jing, GUO Jian-jun, LIN Jun-hui, BU Hai-zhi, CHEN Xi-jing Chinese Journal of Clinical Pharmacology and Therapeutics    2012, 17 (8): 944-949.   Abstract （721）      PDF （269KB）（2916）       Knowledge map    Save Low oral bioavailability of a drug could be attributed to poor absorption and/or extensive first-pass metabolism.The liver and small intestine are the two most important organs for first-pass metabolism. In this review, the important drug-metabolizing enzymes located in the human liver and small intestine are introduced and the effects of different physiological structures of the two organs on overall first-pass metabolism are presented. Moreover, the research advances of the methods used to estimate hepatic and intestinal first-pass metabolism, such as in vitro, in situ, in vivo, in vitro-in vivo combined, knockout and transgenic models, are also summarized. Reference | Related Articles | Metrics

Select

Discussion on dose and dosage regimen exploring and confirming in new drug clinical trials YANG Jin-bo Chinese Journal of Clinical Pharmacology and Therapeutics    2008, 13 (8): 841-846.   Abstract （443）      PDF （237KB）（2837）       Knowledge map    Save It is generally concerned by industries that some important questions in new drug clinical trials from designing the first dose in human to confirm the last dosage regimen, which is also one of the key bottlenecks to restrict the promotion of new drug research and development in China.Based on some references and review experience, this article is to discuss dose and dosage regimen exploring and confirming in new drug clinical trials. Reference | Related Articles | Metrics

Select

Progress in studies of reproductive toxicity of solanine ZHOU Guo-liang, SONG Yi-sheng, XIN Yan-fei, XUAN Yao-xian Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (11): 1291-1296.   Abstract （386）      PDF （268KB）（2786）       Knowledge map    Save Solanine is widely distributed in potatoes, tomatoes and eggplant and other solanaceous plants. It causes widespread concern for anti-tumor and potential toxic effects. This paper reviewed the research progress in the reproductive toxicity studies of solanine. Reference | Related Articles | Metrics

Select

Advances on the study of the pharmacological effects of artemisinin and its derivatives LI Bin, ZHOU Hong Chinese Journal of Clinical Pharmacology and Therapeutics    2010, 15 (5): 572-576.   Abstract （270）      PDF （186KB）（2762）       Knowledge map    Save Artemisinin is a sesquiterpene lactone compounds, their derivatives include mainly dihydroartemisinin, artesunate, artemether and Artemisia ether. These drugs are now mainly used for clinical treatment of malaria. With the pharmacological action of artemisinin and its derivatives have been further studied, except antimalarial effects, researchers have found their anti-inflammatory, anti-sepsis, antitumor, radiosensitization, antimicrobial sensitivity, anti-fibrosis effects in recent years. Here, we collect and review the most newly pharmacological effects of artemisinin and its derivatives all over the world in past years. Reference | Related Articles | Metrics

Select

Advances of the clinical pharmacology of hydroxychloroquine sulfate CUI Cheng, YAO Xueting, TU Siqi, XIE Jieen, LI Haiyan, LIU Dongyang Chinese Journal of Clinical Pharmacology and Therapeutics    2020, 25 (2): 221-226.   DOI: 10.12092/j.issn.1009-2501.2020.02.016 Abstract （956）      PDF （350KB）（2751）       Knowledge map    Save As the number of novel coronavirus disease (COVID-19) continues to increase, the medical situation is still critical, and potential therapeutic drugs, vaccines and stem cell replacement approaches are emerging. Chloroquine has shown better clinical antiviral efficacy than lopinavir/litonavir (clazidine) in clinical trials of small sample size. Since pharmacological action mechanism of hydroxychloroquine is similar with chloroquine and hydroxychloroquine is safer than chloroquine in the treatment of malaria and immunological diseases, the clinical pharmacology characteristics of hydroxychloroquine was reviewed, hoping to provide theoretical support for clinical effect verification of hydroxychloroquine from the perspective of clinical pharmacology and quantitative pharmacology. Related Articles | Metrics

Select

Chinese Journal of Clinical Pharmacology and Therapeutics    2000, 5 (4): 344-348.   Abstract （200）      PDF （197KB）（2713）       Knowledge map    Save Reference | Related Articles | Metrics

Select

Progress of retinoids in the treatment of epidermodysplasia verruciformis LIAO Wei-jian, HUANG Jian-qing Chinese Journal of Clinical Pharmacology and Therapeutics    2014, 19 (1): 112-115.   Abstract （250）      PDF （187KB）（2661）       Knowledge map    Save Retinoids are compounds of similar structures to natural vitamin A. Till now, there are only a few reports that cover Epidermodysplasia verruciformis treated with retinoids. Certain clinical efficacy of Retinoids in dealing with Epidermodysplasia verruciformis has been proved yet the number of the cases is not enough and requires further systematical comparable research. Reference | Related Articles | Metrics

Select

The value and general consideration of pharmacometric study in new drug development LIU Dongyang,WANG Kun,MA Guangli,XIANG Xiaoqiang,LIU Jiang,ZHAO Ping,CHEN Rui,CHEN Yuancheng,HUANG Xiaohui, LI Li,LI Lujin,NIE Jing,WANG Yuzhu,WEI Chunmin,LU Wei,SHI Jun, ZHENG Qingshan Chinese Journal of Clinical Pharmacology and Therapeutics    DOI: 10.12092/j.issn.1009-2501.2018.09.001

Select

Chinese Journal of Clinical Pharmacology and Therapeutics    1998, 3 (2): 140-142.   Abstract （147）      PDF （112KB）（2614）       Knowledge map    Save Reference | Related Articles | Metrics

Select

Actualities of pharmacological effects and clinical application of propolis on oral cavity diseases LIU Hai-Peng, WANG Qin-Mao Chinese Journal of Clinical Pharmacology and Therapeutics    2002, 7 (4): 381-384.   Abstract （274）      PDF （153KB）（2589）       Knowledge map    Save AIM: This paper summarized the actions of propolis on anti-pathogen, anti-inflammation, analgesia, anti-ulcer, sedation, narcosis and so on. An evaluation of the pharmacological effects, and toxicity was also made. In addition, the clinical applications of propolis on oral cavity diseases were induced, such as dental caries, tooth damages, dental pulp diseases, periodontium diseases, and oral mucosa diseases. This article also prospected the distinctive advantages and application foreground of propolis as a kind of high-efficiency natural medicinal material. Reference | Related Articles | Metrics

Select

Advances and future research prospects in regulatory policies for clinical trials of artificial intelligence medical devices LIANG Hao, WANG Shun, CUI Cheng, SONG Ling, SUN Ailin, LI Man, QIAO Jie, SONG Chunli, LI Haiyan, ZHAO Yangguang, LI Haiyan, ZHANG Chenguang, LIU Dongyang Chinese Journal of Clinical Pharmacology and Therapeutics    2025, 30 (3): 427-431.   DOI: 10.12092/j.issn.1009-2501.2025.03.017 Abstract （359）      PDF （581KB）（2577）       Knowledge map    Save Artificial intelligence (AI) has emerged as a cutting-edge technology leading the future and is a key engine for China's development. In the innovation and research of medical devices, AI has provided critical support in the areas of intelligent diagnostic assistance, intelligent therapeutic assistance, intelligent monitoring, life support, et al. Machine learning-enabled device software functions (ML-DSFs) have become an essential component of many medical devices. Recently, the United States Food and Drug Administration (FDA) released a draft guidance titled " Marketing Submission Recommendations for a Predetermined Change Control Plan for Artificial Intelligence/Machine Learning (AI/ML)-Enabled Device Software Functions (Draft). " that aimed to provide a forward-looking approach to foster the development of ML medical devices. By supporting iterative updates through modifications, this approach ensures the continuous safety and effectiveness of the devices. This guidance represents the latest in regulatory direction and is especially beneficial for enhancing the quality and efficiency of clinical trials for AI products. Therefore, we plan to provide a detailed introduction and interpretation of the guidance, with the aim of learning from international advanced regulatory concepts and experiences to promote the development of ML-DSFs with more profound international influence. Related Articles | Metrics

Select

Resent studies on cytochrome P450 and drug metabolism ZHU Li-Qin, LOU Jian-Shi Chinese Journal of Clinical Pharmacology and Therapeutics    2004, 9 (10): 1081-1086.   Abstract （279）      PDF （207KB）（2563）       Knowledge map    Save Cytochrome P450 is one of the important drug metabolization enzymes in humans. This paper reviews drug-relevant CYP, the relationship of CYP and drug interaction, and effects of Chinese medicine on CYP. The aim is to answer and predict the clinical drug interaction and the adverse drug reactions. Moreover, suitable drug can be selected to evaluate the action of CYP, and it can offer the scientific assurance for clinical individual therapy. Reference | Related Articles | Metrics

Select

Mouse models of type 2 diabetes mellitus LIU Qian, LI Xia-hui, ZHANG Xue-mei Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (10): 1196-1200.   Abstract （892）      PDF （825KB）（2500）       Knowledge map    Save Type 2 diabetes was a disease influenced by genetic factors and environmental factors. Animal models of diatetes were essential tools for the understand of the pathogenesis、prevention and treatment of diabetes and its complications. Diabetes mouse models were normally classified into three classes which were spontaneously induced diabetes mouse, experimentally induced diabetes mouse and transgenic diabetes mouse. Each diabetes mouse only imitated clinical diabetes in some aspects and he characteristics of each model about mechanisms and physiology were described in this article. Researchers should choose the suitable diabetes mouse according to their research purpose. Reference | Related Articles | Metrics

Select

Advancement in pharmacokinetic mechanisms of herb-drug interaction HE Ji-chao, ZHOU Fang, ZHANG Jing-wei, YAN Ting-ting, WANG Guang-ji Chinese Journal of Clinical Pharmacology and Therapeutics    2014, 19 (4): 470-475.   Abstract （510）      PDF （316KB）（2482）       Knowledge map    Save Recently, there is a dramatic increase in the combination use of traditional Chinese medicine and western drug, causing various drug interactions and adverse effects. This combination can not only change physiochemical properties of the related drugs and physiological nature of human body, but regulate expression and function of drug metabolizing enzymes and transporters, which a play key role in drug metabolism and disposition in vivo. Pharmacokinetic interaction then takes place frequently, together with alteration in clinical outcome. The paper summarizes the pharmacokinetics and assessment approaches of herb-drug interaction, acting as a reference for practical use and research. Reference | Related Articles | Metrics

Select

TU Jiao, CHEN Hui, NI Ping, QI Xiao, XIAO Wan, XU Lin-Yong Chinese Journal of Clinical Pharmacology and Therapeutics    2015, 20 (9): 1011-1019.   Abstract （1238）      PDF （3781KB）（2430）       Knowledge map    Save Related Articles | Metrics