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Chinese Journal of Clinical Pharmacology and Therapeutics    2016, 21 (2): 218-224.   Abstract （975）      PDF （3257KB）（2826）       Knowledge map    Save Related Articles | Metrics

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Effects of ginsenoside C-K on seizure activity in pilocarpine-induced epileptic rats ZENG Xiangchang, ZHOU Luping, CHEN Lulu, LUO Wei, LI Chaopeng, GAO Qing, WANG Yaqin, WANG Xintong, HU Kai, SHEN Jie, OUYANG Dongsheng Chinese Journal of Clinical Pharmacology and Therapeutics    2017, 22 (2): 139-143.   Abstract （475）      PDF （2116KB）（2298）       Knowledge map    Save AIM: To investigate the effects of ginsenoside C-K on behavior in epileptic rats and its synergistic effect with lamotrigine. METHODS: 70 male SD rats were randomly divided into normal group, model group, lamotrigine group, ginsenoside C-K low, middle, high group, lamotrigine and ginsenoside C-K combination group. Rats in model group and treatment group were prepared for epilepsy animal model by intraperitoneal injection of lithium chloride-pilocarpine after administration of lamotrigine or ginsenoside C-K. Behavior changes were closely observed by video monitoring system after pilocarpine. Behavioural seizure activity was scored according to Racine grading standard and recorded seizure latency. RESULTS: After treatment of ginsenoside C-K, the treatment group rats exhibited significant an increase in seizure latency compared with epilepsy model group. The loss of body wieght reduced significantly in these surviving animals pretreated with ginsenoside C-K(n=10, P＜0.05). Intriguingly, the complex of ginsenoside C-K and lamotrigine reduces seizure intensities, seizure latency was further prolonged(n=10, P＜0.05). CONCLUSION: Ginsenoside C-K can exhibit an antiepileptic effect. The combination of ginsenoside C-K and lamotrigine have synergistic anti-epileptic effect. Reference | Related Articles | Metrics

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TU Jiao, CHEN Hui, NI Ping, QI Xiao, XIAO Wan, XU Lin-Yong Chinese Journal of Clinical Pharmacology and Therapeutics    2015, 20 (9): 1011-1019.   Abstract （883）      PDF （3781KB）（2273）       Knowledge map    Save Related Articles | Metrics

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Dose conversion among different animals and healthy volunteers in pharmacological study HUANG Ji-Han,HUANG Xiao-Hui, CHEN Zhi-Yang, ZHENG Qing-Shan, SUN Rui-Yuan Chinese Journal of Clinical Pharmacology and Therapeutics    2004, 9 (9): 1069-1072.   Abstract （579）      PDF （152KB）（2189）       Knowledge map    Save In order to obtain equivalent dose, a dose conversion was important among different animals and healthy volunteers in preclinical pharmacology and I phase clinical trials. Body coefficient and standard weight were introduced into the formula to estimate the equivalent dose in this paper. Reference | Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    2016, 21 (2): 231-236.   Abstract （408）      PDF （2748KB）（2103）       Knowledge map    Save Related Articles | Metrics

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The value and general consideration of pharmacometric study in new drug development LIU Dongyang,WANG Kun,MA Guangli,XIANG Xiaoqiang,LIU Jiang,ZHAO Ping,CHEN Rui,CHEN Yuancheng,HUANG Xiaohui, LI Li,LI Lujin,NIE Jing,WANG Yuzhu,WEI Chunmin,LU Wei,SHI Jun, ZHENG Qingshan Chinese Journal of Clinical Pharmacology and Therapeutics    DOI: 10.12092/j.issn.1009-2501.2018.09.001

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Progress in research and evaluation on drug-plasma protein binding in pharmacology GUO Bin, LI Chuan Chinese Journal of Clinical Pharmacology and Therapeutics    2005, 10 (3): 241-253.   Abstract （249）      PDF （406KB）（1761）       Knowledge map    Save Drug-protein binding changes involved in numerous factors in vivo may cause changes of pharmacokinetic parameters.The tendency gained from large numbers of articles overemphasized the clinical importance of these changes.However, theoretic analysis and review of available literature data indicated that changes in plasma protein binding are usually of no principle pharmacodynamic implication.And they have little effect on the clinical exposure of a patient to a drug in a practical sense. The progress is reviewed in research and current opinions on drug-plasma protein binding in pharmacological basis for pharmacokinetic consequence and clinical relevance in this article. Reference | Related Articles | Metrics

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Analysis of metabolomic data: principal component analysis Jiye Aa Chinese Journal of Clinical Pharmacology and Therapeutics    2010, 15 (5): 481-489.   Abstract （709）      PDF （913KB）（1647）       Knowledge map    Save Metabolomics has been widely applied to life science and showing a promising perspective. Conventional statistic analysis is not applicable to the large, multivariate dataset generated by high-throughput metabolomic tool, while it's of crucial importance to analyze and interpret the dataset. This article reviews the basic methods of principal components analysis(PCA) that is popular in metabolomics study, aiming at strengthening the fundamental knowledge of PCA and standardizing the methods and procedures for data analysis. Reference | Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    2001, 6 (2): 97-102.   Abstract （144）      PDF （195KB）（1641）       Knowledge map    Save Related Articles | Metrics

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Chemical constituents and Pharmacology of Eucommia ulmoides Oliv. FENG Han, ZHOU Hong-Hao, 欧Yang-Dong-Sheng Chinese Journal of Clinical Pharmacology and Therapeutics    2015, 20 (6): 713-720.   Abstract （887）      PDF （3364KB）（1447）       Knowledge map    Save Eucommia ulmoide is an ancient species left in tertiary glacier movement. The active phytochemicals found in E.ulmoides are divided into lignans, iridoids, flavonoids, phenylpropanoids, terpenoids and polysaccharide. Eucommia ulmoide displays extensive pharmacological action, as anti-hypertension, anti-hyperlipidemia, anti-hyperglycemic, anti-tumor, anti-bacterial, anti-virus, anti-inflammatory, anti-oxidative, hepatoprotection, renoprotection and anti-osteoporosis. E.ulmoide has long medical history in China, Korea and Japan. This review summarizes the progress in chemistry and pharmacology of E.ulmoides. Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    2000, 5 (2): 162-163.   Abstract （61）      PDF （74KB）（1417）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    2000, 5 (4): 344-348.   Abstract （53）      PDF （197KB）（1342）       Knowledge map    Save Reference | Related Articles | Metrics

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Advances of the clinical pharmacology of hydroxychloroquine sulfate CUI Cheng, YAO Xueting, TU Siqi, XIE Jieen, LI Haiyan, LIU Dongyang Chinese Journal of Clinical Pharmacology and Therapeutics    2020, 25 (2): 221-226.   DOI: 10.12092/j.issn.1009-2501.2020.02.016 Abstract （606）      PDF （350KB）（1312）       Knowledge map    Save As the number of novel coronavirus disease (COVID-19) continues to increase, the medical situation is still critical, and potential therapeutic drugs, vaccines and stem cell replacement approaches are emerging. Chloroquine has shown better clinical antiviral efficacy than lopinavir/litonavir (clazidine) in clinical trials of small sample size. Since pharmacological action mechanism of hydroxychloroquine is similar with chloroquine and hydroxychloroquine is safer than chloroquine in the treatment of malaria and immunological diseases, the clinical pharmacology characteristics of hydroxychloroquine was reviewed, hoping to provide theoretical support for clinical effect verification of hydroxychloroquine from the perspective of clinical pharmacology and quantitative pharmacology. Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    2016, 21 (5): 595-600.   Abstract （292）      PDF （2768KB）（1293）       Knowledge map    Save Related Articles | Metrics

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Sample size estimation in randomized controlled drug clinical trials LI Chan-juan, JIANG Zhi-wei, WANG Rui, XIA Jie-lai Chinese Journal of Clinical Pharmacology and Therapeutics    2011, 16 (10): 1132-1136.   Abstract （601）      PDF （223KB）（1274）       Knowledge map    Save Sample size estimation is a key research aspect in randomized controlled drug clinical trial. Sample size estimation factors, parameters and basic rules are discussed in our research. In addition, sample size estimation procedures are introduced based on two examples. A reference is provided for estimating sample size in randomized controlled clinical trials. Reference | Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    2016, 21 (3): 354-360.   Abstract （349）      PDF （3229KB）（1249）       Knowledge map    Save Related Articles | Metrics

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Discussion on dose and dosage regimen exploring and confirming in new drug clinical trials YANG Jin-bo Chinese Journal of Clinical Pharmacology and Therapeutics    2008, 13 (8): 841-846.   Abstract （166）      PDF （237KB）（1209）       Knowledge map    Save It is generally concerned by industries that some important questions in new drug clinical trials from designing the first dose in human to confirm the last dosage regimen, which is also one of the key bottlenecks to restrict the promotion of new drug research and development in China.Based on some references and review experience, this article is to discuss dose and dosage regimen exploring and confirming in new drug clinical trials. Reference | Related Articles | Metrics

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Research progress in medicine for treating gout and hyperuricemia CHEN Guangliang, ZHOU Yuanfeng, ZHANG Ying Chinese Journal of Clinical Pharmacology and Therapeutics    2017, 22 (1): 104-109.   Abstract （388）      PDF （2755KB）（1199）       Knowledge map    Save Compared with the conventional dose regimen, small dose of colchicine or small dose of colchicine and anti-inflammatory drug treatment show similar effect in treating acute gouty arthritis, while the safety is greatly improved. IL-1 receptor antagonists anakinra, rilonacept, and canakinumab can effectively alleviate the symptoms of acute phase of gout, and have become the fourth types of anti-acute gout drugs. The severe hypersensitivity syndrome of allopurinol is related to renal function, starting dose and HLA-B*5801 gene. Febuxostat, topiroxosta, ulodesine, lesinurad, RDEA-3170, uric acid enzyme are recently new drugs to reduce uric acid. Reference | Related Articles | Metrics

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ZHANG Xuan, YAN Dong, GAO Jing, XIE Xiao-Qing Chinese Journal of Clinical Pharmacology and Therapeutics    2015, 20 (10): 1115-1121.   Abstract （350）      PDF （2792KB）（1192）       Knowledge map    Save Related Articles | Metrics

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Research progress of alopecia experimental model and its pharmacotherapeutics JIN Jianbo, ZHANG Jianhua Chinese Journal of Clinical Pharmacology and Therapeutics    2017, 22 (1): 115-120.   Abstract （426）      PDF （2893KB）（1161）       Knowledge map    Save Alopecia is a kind of disease characterized by loss of hair. Pathophysiological mechanism of alopecia and its hair regeneration therapy is the pressing issues of current study. The successful replication of Alopecia experimental model plays a key role in promoting the study of pathological mechanism and pharmacotherapeutics. This review systematically describes the progress in alopecia animal model and in vitro organ model, which have been established at home and abroad. Based upon the aforementioned experimental models, some relevant applications in experimental therapeutics are simultaneously enumerated. Hopefully all these information facilitate the researchers according to the need to select the appropriate model to carry out the experiment.  Reference | Related Articles | Metrics

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Recent advancement in pharmacological effects of artemisinin and its derivatives GUO Yan, WANG Jun, CHEN Zheng-tang Chinese Journal of Clinical Pharmacology and Therapeutics    2006, 11 (6): 615-620.   Abstract （121）      PDF （207KB）（1142）       Knowledge map    Save Artemisinin, an active compound extracted from Artemisia annua, L.together with its derivatives are widely used as anti-malarial drugs.In recent years, artemisinin and many of its analogs were reported to possess some other effects such as anti-inflammatory, immuno-modulation and antitumor activities besides antiparasitic actions against Plasmodium falciparum and Schistosoma.Based on an introduction of the conventional actions and mechanisms of these drugs, we reviewed the recent progress of their new biological actions in this article. Reference | Related Articles | Metrics

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Advances on the study of the pharmacological effects of artemisinin and its derivatives LI Bin, ZHOU Hong Chinese Journal of Clinical Pharmacology and Therapeutics    2010, 15 (5): 572-576.   Abstract （104）      PDF （186KB）（1139）       Knowledge map    Save Artemisinin is a sesquiterpene lactone compounds, their derivatives include mainly dihydroartemisinin, artesunate, artemether and Artemisia ether. These drugs are now mainly used for clinical treatment of malaria. With the pharmacological action of artemisinin and its derivatives have been further studied, except antimalarial effects, researchers have found their anti-inflammatory, anti-sepsis, antitumor, radiosensitization, antimicrobial sensitivity, anti-fibrosis effects in recent years. Here, we collect and review the most newly pharmacological effects of artemisinin and its derivatives all over the world in past years. Reference | Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    2016, 21 (7): 721-730.   Abstract （328）      PDF （3746KB）（1137）       Knowledge map    Save Related Articles | Metrics

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Research advances in models of hepatic and intestinal first-pass drug metabolism ZHU Jing, GUO Jian-jun, LIN Jun-hui, BU Hai-zhi, CHEN Xi-jing Chinese Journal of Clinical Pharmacology and Therapeutics    2012, 17 (8): 944-949.   Abstract （442）      PDF （269KB）（1126）       Knowledge map    Save Low oral bioavailability of a drug could be attributed to poor absorption and/or extensive first-pass metabolism.The liver and small intestine are the two most important organs for first-pass metabolism. In this review, the important drug-metabolizing enzymes located in the human liver and small intestine are introduced and the effects of different physiological structures of the two organs on overall first-pass metabolism are presented. Moreover, the research advances of the methods used to estimate hepatic and intestinal first-pass metabolism, such as in vitro, in situ, in vivo, in vitro-in vivo combined, knockout and transgenic models, are also summarized. Reference | Related Articles | Metrics

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Recognition of the clinical application and biological mechanism of ursodeoxycholic acid in liver diseases ZHANG Linlin, FAN Yujuan, TAN Bo, LI Yue, JIANG Jian, QIU Furong Chinese Journal of Clinical Pharmacology and Therapeutics    2017, 22 (2): 233-240.   Abstract （311）      PDF （3667KB）（1119）       Knowledge map    Save Ursodeoxycholic acid （UDCA）has been widely used in clinical treatment of liver disease due to its hepato-protective effect, including primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and cystic fibrosis (CF), etc. Lack of effective drug as control, UDCA's clinical effect and mechanism of action remain unclear. Recently, the reports about adverse events caused by UDCA, especially at high dosage have been increasing. This review summarizes the clinical application and mechanism of UDCA in treatment of liver diseases, which is referential for its clinical application. Reference | Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    1997, 2 (4): 295-298.   Abstract （63）      PDF （170KB）（1063）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    2016, 21 (5): 562-566.   Abstract （213）      PDF （2125KB）（993）       Knowledge map    Save Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    1998, 3 (2): 140-142.   Abstract （57）      PDF （112KB）（992）       Knowledge map    Save Reference | Related Articles | Metrics

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Study of the algorithm of elimination half-life time in pharmacokinetics CHEN Chao, XU Ling, ZHENG Qing-shan Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (8): 891-896.   Abstract （467）      PDF （1216KB）（981）       Knowledge map    Save AIM: To study a reasonable algorithm of terminal half-life time (t1/2z) in pharmacokinetics by the accuracy and precision.METHODS: The plasma concentration-time data of pu- erarin was simulated for 1000 subjects by using parameters of intravenous two-compartment models in the variations of 15%, 25% and 35%. Resampling 15, 25, 35, and 45 from the 1000 subjects were used to calculate t1/2z by 4-point, 5-point, 6-point, all-point methods when there were different points in eliminate phase. The results of these methods were compared to the true value and expressed by accuracy and precision.RESULTS: The 5-point method can provide a t1/2z with better accuracy and precision when there are four concentration points in eliminate phase, the 4-point method provide the one with better accuracy in three points in eliminate phase, 6-point method provide t1/2z with better precision in both three and four points in eliminate phase. There is no reasonable t1/2z in all four methods if there are two points in eliminate phase.CONCLUSION: Three concentration points should be at least included in eliminating phase for calculating a t1/2z which is usually more reasonable in 4-points or 5-points method. Reference | Related Articles | Metrics

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Mouse models of type 2 diabetes mellitus LIU Qian, LI Xia-hui, ZHANG Xue-mei Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (10): 1196-1200.   Abstract （362）      PDF （825KB）（976）       Knowledge map    Save Type 2 diabetes was a disease influenced by genetic factors and environmental factors. Animal models of diatetes were essential tools for the understand of the pathogenesis、prevention and treatment of diabetes and its complications. Diabetes mouse models were normally classified into three classes which were spontaneously induced diabetes mouse, experimentally induced diabetes mouse and transgenic diabetes mouse. Each diabetes mouse only imitated clinical diabetes in some aspects and he characteristics of each model about mechanisms and physiology were described in this article. Researchers should choose the suitable diabetes mouse according to their research purpose. Reference | Related Articles | Metrics

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Application of biomarkers in clinical development of biologics and bioanalytical strategies CHE Jinjing Chinese Journal of Clinical Pharmacology and Therapeutics    2020, 25 (1): 22-31.   DOI: 10.12092/j.issn.1009-2501.2020.01.004 Abstract （628）      PDF （4250KB）（976）       Knowledge map    Save China's biologic drug research and development is on a fast track lane. The rising cost of new drug development has not improved the success rate of drug launch, and a shift in the model of drug development is urgently needed. In order to improve the success rate, a biomarker strategy of the new drug development model has been proposed and is generally accepted. This paper reviews the research and development of new translational medicine drugs with biomarkers as the core, the application of biomarkers in the clinical study of biological drugs, biomarker biological analysis strategies, and the opportunities and challenges of biomarkers in the clinical study of biological drugs. By comparing international standards, seeking China's advantages and seeking opportunities from the research and development model of translational medicine based on biomarkers, China can make innovative drugs with global influence in the near term. Reference | Related Articles | Metrics

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Progress in research of phase Ⅱ metabolisms and their enzymes SHI Shu-ya, WANG Lian-sheng Chinese Journal of Clinical Pharmacology and Therapeutics    2014, 19 (1): 82-89.   Abstract （336）      PDF （326KB）（974）       Knowledge map    Save Phase Ⅱ drug-metabolizing reaction, characterized by the conjugation reaction, is an important way of body drug disposition. Glucuronidation, acetylation, methylation, glutathione conjugation reaction, and sulphation represent different conjugation reactions and are catalyzed by some similar genes or gene superfamily respectively. All these phase Ⅱ metabolic reactions have their own different characteristics and functional significance. Drug induced significant change of phase Ⅱ drug metabolizing enzyme activity may lead to clinical drug interactions. The genetic polymorphisms of phase Ⅱdrug metabolizing enzymes will affect the metabolism of endogenous substances, which may lead to the increased incidence of certain diseases, and these polymorphisms also affect the metabolism of exogenous substances, causing toxicity or changes in drug efficacy. Reference | Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    2016, 21 (4): 458-462.   Abstract （367）      PDF （2165KB）（972）       Knowledge map    Save Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    2000, 5 (3): 269-269.   Abstract （238）      PDF （48KB）（965）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    2001, 6 (4): 289-292.   Abstract （73）      PDF （137KB）（942）       Knowledge map    Save Reference | Related Articles | Metrics

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Advances in study of estrogen and its receptors signal transduction pathway FAN Guan-wei, HE Jun, WANG Hong, GAO Xiu-mei Chinese Journal of Clinical Pharmacology and Therapeutics    2007, 12 (3): 266-269.   Abstract （92）      PDF （155KB）（912）       Knowledge map    Save Estrogen gradually becomes the research hot spot because it has extensive biological effect, which exerts its function by binding to estrogen receptors (ERs).ERs have the widespread organization distribution, including the reproductive system, the skeleton and the cardiovascular system, and these provided the guarantee for the estrogen to display biology effect.This article reviews the advance of estrogen and its receptors signal transduction pathway in abroad and domestic. Reference | Related Articles | Metrics

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Research development between JNK pathway and apoptosis WEI Na, HE Hai-bo, ZHANG Chang-cheng, YUAN Ding, WANG Ting Chinese Journal of Clinical Pharmacology and Therapeutics    2013, 18 (7): 807-812.   Abstract （451）      PDF （261KB）（881）       Knowledge map    Save JNK pathway is closely associated with cell differentiation, apoptosis, stress response and many hunman diseases in the past 20 years, whose biochemical function, regulation under cell physiology and pathology are constantly noticed by domestic and foreign scholars. Recently, more research suggests that it plays an important role in regulating apoptosis, and it will be an important potential target for treatment of apoptosis-associated disease by regulating JNK signal pathway. In summary, the physiological and pathophysiological functions of JNK pathway and relation with apoptosis have been reviewed. Reference | Related Articles | Metrics

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XIANG Yu-Xia, PENG Jin-Fu, HUANG Jie, LIU Chang, YANG Guo-Ping Chinese Journal of Clinical Pharmacology and Therapeutics    2015, 20 (8): 928-932.   Abstract （296）      PDF （2057KB）（868）       Knowledge map    Save Related Articles | Metrics

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Research advance on the characteristics and application of CYP450 metabolic enzymes LI Xiao-yu, LIU Gao-lin Chinese Journal of Clinical Pharmacology and Therapeutics    2008, 13 (8): 942-946.   Abstract （188）      PDF （177KB）（862）       Knowledge map    Save Cytochrome P450 is an important kind of enzymes for the metabolism of drug and other endoor xeno-biotics.Classification of metabolic enzymes, molecular biological characteristic of CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP2E1, CYP1A2 and CYP2A6were described in this review.Influence of traditional Chinese medicine (TCM)on metabolic enzyme and its application in clinical drug therapeutics and drug development were also reviewed in this article. Reference | Related Articles | Metrics

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Chinese Journal of Clinical Pharmacology and Therapeutics    2015, 20 (11): 1296-1301.   Abstract （204）      PDF （2698KB）（854）       Knowledge map    Save Related Articles | Metrics