中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (2): 156-159.DOI: 10.11852/zgetbjzz2019-1833

• 科研论著 • 上一篇    下一篇

婴儿期生长情况对青春期性发育的影响研究

万斌1, 何淼2, 郭春艳2, 詹海荣1   

  1. 1.湖北医药学院附属十堰市人民医院预防保健部,湖北 十堰 442000;
    2.陕西省安康市白河县中医院儿科
  • 收稿日期:2020-01-03 修回日期:2020-09-10 出版日期:2021-02-10 发布日期:2021-02-10
  • 通讯作者: 詹海荣,E-mail:1139923149@qq.com
  • 作者简介:万斌(1976-),男,湖北人,副主任医师,硕士研究生学历,主要研究方向为从事小儿先天性心脏病及儿童保健。

Effect of infant growth on adolescent sexual development

WAN Bin*, HE Miao, GUO Chun-yan, ZHAN Hai-rong   

  1. *Department of Preventive Health, Shiyan People's Hospital, Hubei Medical College, Shiyan, Hubei 442000, China
  • Received:2020-01-03 Revised:2020-09-10 Online:2021-02-10 Published:2021-02-10

摘要: 目的 探讨婴儿期快速生长对青春期性发育的影响,对预防未来青春期提早发育提供依据。方法 选择2004年1月-2005年1月在温州市儿童医院及本院体检的198例生长过快的婴儿为观察组,另选择175名正常婴儿为对照组。根据出现月经初潮/遗精的时间点,把观察组分成性早熟组和正常发育组。采用Spearman相关性分析观察组婴儿1周岁的身高Δ值、体重Δ值与青春期性早熟的相关性。结果 观察组婴儿1周岁的身高Δ值、体重Δ值均显著大于对照组,差异有统计学意义(t=2.085,2.146,P<0.05);观察组儿童的身高、体重、体脂、骨龄值均显著大于对照组儿童,观察组儿童的T、E2、FSH、LH水平均显著高于对照组儿童,差异均有统计学意义(P<0.05)。对照组无性早熟患儿。观察组、早熟组和正常组的男女比例对比,差异无统计学意义(P>0.05)。早熟组身高、体重、体脂、骨龄值均显著大于正常组,早熟组T、E2、FSH、LH水平均显著高于正常组,差异有统计学意义(P<0.05)。观察组婴儿1周岁的身高Δ值、体重Δ值与青春期性早熟呈正相关(r=0.816,0.872,P<0.001)。结论 婴儿期快速生长可造成儿童青春期前肥胖和体脂过度,使青春期早发。控制婴儿期过快生长对预防未来青春期提早发育有重要意义。

关键词: 婴儿期, 快速生长, 青春期早发, 性早熟, 肥胖

Abstract: Objective To explore the effect of rapid growth in infancy on puberty sexual development, in order to provide reference for preventing early puberty in the future. Methods From January 2004 to January 2005, 198 infants who grew too fast were selected as the observation group and 175 normal infants were selected as the control group from Wenzhou Children's Hospital and Shiyan People's Hospital. According to the time point of menarche/ spermatorrhea, the observation group was divided into precocious puberty group and normal development group. Spearman correlation analysis was used to analyze the correlation between height Δvalue, weight Δvalue and puberty precocious puberty in the observation group. Results The height Δvalue and weight Δvalue of one-year-old infants in the observation group were significantly higher than those in the control group (t=2.085,2.146,P<0.05). The height, weight, body fat and bone age of children in the observation group were significantly higher than those in the control group, and the levels of testosterone(T), estradiol(E2), follicle stimulating hormone(FSH) and luteinizing hormone(LH) in the observation group were significantly higher than those in the control group (P<0.05). There were no sexual precocious children in the control group. There was no significant difference in gender among the precocious group,the normal group and the observation group (P>0.05). The height, weight, body fat and bone age of the precocious group were significantly higher than those of the normal group, and the levels of T, E2, FSH and LH in the precocious group were significantly higher than those in the normal group (P<0.05).There was a positive correlation between the height Δvalue and the weight Δvalue of one year old infants in the observation group and puberty precocious puberty (r=0.816, 0.872, P<0.001). Conclusions Rapid growth in infancy can lead to pre-puberty obesity and excessive body fat, and early puberty. It is of great significance to control the overgrowth during infancy for the prevention of early puberty in the future.

Key words: infant period, rapid growth, early puberty, sexual precocity, obesity

中图分类号: