儿童肥胖相关心肌病的分子机制

doi:10.11852/zgetbjzz2022-0978

摘要/Abstract

摘要： 肥胖并发症随着肥胖发病率的不断增长呈现逐年上升趋势。研究表明,心血管疾病的风险增加与肥胖密切相关:冠状动脉粥状硬化、心力衰竭和心律失常。同时肥胖也与心肌肥厚、心室收缩功能障碍和舒张顺应性降低等发生发展有关。单纯性肥胖儿童心脏舒张功能较正常体重儿童明显降低,肥胖导致心肌病的病理机制有多种,包括胰岛素抵抗、炎症、氧化应激、脂肪毒性、调亡和线粒体自噬等。肥胖导致心脏结构和功能发生变化的精确分子机制仍不清楚。本文就肥胖所致心肌重构的可能分子机制做一简要综述,为临床上儿童肥胖相关心肌病的防治提供理论依据。

关键词: 儿童肥胖, 心肌病, 分子机制

Abstract: Childhood obesity complications are increasing year by year with the continuous growth of obesity incidence rate.Studies have shown that the increased risk of cardiovascular disease (coronary atherosclerosis, heart failure and arrhythmia) is closely related to obesity.Additionally, obesity is also related to the occurrence and development of myocardial hypertrophy, ventricular systolic dysfunction and reduced diastolic compliance.The diastolic function of simple obese children is significantly lower than that of normal weight children.There are many pathological mechanisms of cardiomyopathy caused by obesity, including insulin resistance, inflammation, oxidative stress, lipotoxicity, apoptosis and mitochondrial autophagy.However, the precise molecular mechanism by which obesity leads to changes in cardiac structure and function remains unclear.This article briefly reviews the possible molecular mechanisms of obesity-induced myocardial remodeling, and provides theoretical basis for the prevention and treatment of obesity related cardiomyopathy in children.

Key words: childhood obesity, cardiomyopathy, molecular mechanism

中图分类号:

R723.14

牛婉侠, 梁爽, 王一彪. 儿童肥胖相关心肌病的分子机制[J]. 中国儿童保健杂志, 2023, 31(5): 507-511.

NIU Wanxia, LIANG Shuang, WANG Yibiao. Molecular mechanism of childhood obesity related cardiomyopathy[J]. Chinese Journal of Child Health Care, 2023, 31(5): 507-511.

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