关键词: 克龄蒙, 戈舍瑞林, 子宫内膜异位症, 腹腔镜手术, 性激素, 不良反应

Abstract:

AIM: To investigate the effects of climen associated with goserelin on serum hormone levels of laparoscopic surgery in patients with ectopic endometrium after laparoscopic hysterectomy.  METHODS: Eighty-one patients with endometriosis were divided into study group and control group. All patients were treated with laparoscopic surgery. The control group was given goserelin treatment after operation. The research group was given climen treatment based on the control group. The levels of E2, FSH, LH and CA125 were detected before and after treatment in the two groups. Adverse reactions were recorded in the two groups. The patients were followed up for 6 months after the treatment, and the pregnancy and recurrence of the two groups were recorded. RESULTS:The total effective rates of the two groups were compared. The difference was not statistically significant (P>0.05). After treatment, E2, FSH, LH, CA125 in two groups were significantly lower than those before treatment (P<0.05). After treatment, the levels of E2 and LH in the study group were significantly higher than those in the control group, and FSH was significantly lower than that in the control group. The difference was statistically significant (P<0.05). Comparison of CA125 in two groups after treatment, the difference was not statistically significant (P>0.05). The incidence of adverse reactions in the study group (9.76%) was significantly lower than that in the control group (27.50%). The difference was statistically significant (P<0.05). The recurrence rate and pregnancy rate of the study group were compared with those of the control group. The difference was not statistically significant (P>0.05). CONCLUSION: Climen associated with goserelin can significantly improve the levels of E2, LH in patients with endometriosis after laparoscopic surgery and reduce the occurrence of adverse reaction.

Key words: climen, goserelin, endometriosis, laparoscopic surgery, sex hormone, adverse reaction