miR-423-5p、TFFs、NAG-1在抗NASIDs致胃黏膜损伤中作用研究进展

doi:10.12092/j.issn.1009-2501.2018.09.017

中国临床药理学与治疗学 ›› 2018, Vol. 23 ›› Issue (9): 1068-1074.doi: 10.12092/j.issn.1009-2501.2018.09.017

miR-423-5p、TFFs、NAG-1在抗NASIDs致胃黏膜损伤中作用研究进展

李小妹¹, 李小琴¹, 贺海波¹, 张永峰², 许海燕¹, 张继红³, 汪鋆植⁴, 罗涛³

¹三峡大学生物与制药学院天然产物研究与利用湖北省重点实验室& 湖北省土家族医药研究所，宜昌 443002，湖北； ²三峡大学中医医院＆宜昌市中医医院消化内科，宜昌 443002，湖北

收稿日期:2017-07-05 修回日期:2018-08-29 出版日期:2018-09-26 发布日期:2018-09-26
通讯作者: 贺海波，男，博士，副教授，硕士生导师，研究方向:土家药物药效物质基础和作用机制。 Tel：0717-6397478 E-mail：hjy219@126.com
作者简介:李小妹，女，硕士研究生，主要从事天然药物活性评价研究。 Tel：13972570192 E-mail：984911134@qq.com
基金资助:
三峡大学硕士学位论文培优基金项目(2017YPY086，2018SSPY140)；湖北省生物酵素工程研究技术研究中心项目JS2018-06)

Research progress of miR-423-5p, TFFs and NAG-1 in anti NASIDs induced gastric mucosal injury

LI Xiaomei¹, LI Xiaoqin¹, HE Haibo¹, ZHANG Yongfeng¹, XU Haiyan¹, QIN Huilin², ZHANG Jihong², WANG Junzhi¹, LUO Tao²

¹Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences & Research Institute of Tujia Medicine, China Three Gorges University, Yichang 443002, Hubei, China; ²Department of Gastroenterology, Traditional Chinese Medicine Hospital of China Three Gorges University & Yichang Hospital of Traditional Chinese Medicine, Yichang 443002, Hubei, China

Received:2017-07-05 Revised:2018-08-29 Online:2018-09-26 Published:2018-09-26

摘要/Abstract

摘要：

非甾体抗炎药(NSAIDs)是临床上广泛应用的一类解热镇痛药物，然而NSAIDs致胃黏膜损伤同样常见。明确NSAIDs致消化道黏膜损伤的发病机制，寻找抗炎作用好、胃黏膜损伤副作用少的新型抗炎药物是许多医药工作者的研究热点。近年来，国内外学者研究表明miR-423-5p、TFFs及NAG-1均参与了胃黏膜损伤的进程，但三者之间的关系尚不明确。本文就NASIDs致胃黏膜损伤机制、三者性质及它们在胃黏膜损伤中作用的相关研究进展进行综述。

关键词: NASIDs致胃黏膜损伤机制, miR-423-5p, TFFs, NAG-1

Abstract:

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of antipyretic and analgesic drugs widely used in clinic. However, gastric mucosal injury caused by NSAIDs is also common. To clarify the pathogenesis of gastrointestinal mucosal injury induced by NSAIDs, and to find new anti-inflammatory drugs with good anti-inflammatory effect and few side effects of gastric mucosal injury are the research hotspots of many medical workers. In recent years, researches at home and abroad have shown that microRNA423-5p, TFFs and NAG-1 are involved in the process of gastric mucosal injury, but the relationship among the aforementioned three is still unclear. This article reviews the mechanism of gastric mucosal injury induced by NASIDs, their properties and their interaction in gastric mucosal injury.

Key words: mechanism of gastric mucosal injury induced by NSAIDs, miR-423-5p, TFFs, NAG-1

中图分类号:

R573

李小妹, 李小琴, 贺海波, 张永峰, 许海燕, 覃慧林，张继红, 汪鋆植, 罗涛. miR-423-5p、TFFs、NAG-1在抗NASIDs致胃黏膜损伤中作用研究进展[J]. 中国临床药理学与治疗学, 2018, 23(9): 1068-1074.

LI Xiaomei, LI Xiaoqin, HE Haibo, ZHANG Yongfeng, XU Haiyan, QIN Huilin, ZHANG Jihong, WANG Junzhi, LUO Tao. Research progress of miR-423-5p, TFFs and NAG-1 in anti NASIDs induced gastric mucosal injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(9): 1068-1074.

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miR-423-5p、TFFs、NAG-1在抗NASIDs致胃黏膜损伤中作用研究进展

Research progress of miR-423-5p, TFFs and NAG-1 in anti NASIDs induced gastric mucosal injury

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