半枝莲抗结直肠癌及其转移机制研究进展

doi:10.12092/j.issn.1009-2501.2019.03.016

中国临床药理学与治疗学 ›› 2019, Vol. 24 ›› Issue (3): 332-336.doi: 10.12092/j.issn.1009-2501.2019.03.016

半枝莲抗结直肠癌及其转移机制研究进展

乔大伟，李玉芳，肖云，姜礼双，卜平

扬州大学临床医学院消化内科，扬州 225001，江苏

收稿日期:2018-10-10 修回日期:2018-10-25 出版日期:2019-03-26 发布日期:2019-04-01
通讯作者: 卜平，男，博士，教授，研究方向：消化系统疾病。 Tel：13852718005 E-mail：boping@yzu.edu.cn
作者简介:乔大伟，男，硕士，研究方向：消化道肿瘤。 Tel：15705275020 E-mail：qiao_dawei@126.com
基金资助:
国家自然科学基金（81673736）；江苏省研究生科研与实践创新计划项目（SJCX18_0808）

Research progress of Scutellaria barbata against colorectal cancer and its metastasis mechanism

QIAO Dawei, LI Yufang, XIAO Yun, JIANG Lishuang, BO Ping

Department of Gastroenterology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China

Received:2018-10-10 Revised:2018-10-25 Online:2019-03-26 Published:2019-04-01

摘要/Abstract

摘要：

结直肠癌是消化道常见的恶性肿瘤之一，因其难以根除且极易发生转移，给治疗带来难度。近年来研究显示，中药半枝莲能通过多种途径对结直肠癌及其转移进行分子靶向治疗，主要有信号传导通路、相关抑癌基因、端粒酶活性、机体免疫力4个方面。本文综述半枝莲对结直肠癌及其转移的治疗分子机制，以期为临床应用提供参考。

关键词: 半枝莲, 结直肠癌, 转移, 分子机制

Abstract:

Colorectal cancer is one of the common malignant tumors in the digestive tract. Because it is difficult to eradicate and it is highly prone to metastasize, it brings difficulty in treatment. In recent years, studies have shown that traditional Chinese medicine Scutellaria barbata can be used for molecular targeted therapy of colorectal cancer and its metastasis through a variety of approaches, mainly including four aspects: signal transduction pathways, related tumor suppressor genes, telomerase activity, and body immunity. Here we review the main approaches in hope of providing referential idea for its clinical application.

Key words: Scutellaria barbata, colorectal cancer, metastasis, molecular mechanism

中图分类号:

乔大伟，李玉芳，肖云，姜礼双，卜平. 半枝莲抗结直肠癌及其转移机制研究进展[J]. 中国临床药理学与治疗学, 2019, 24(3): 332-336.

QIAO Dawei, LI Yufang, XIAO Yun, JIANG Lishuang, BO Ping. Research progress of Scutellaria barbata against colorectal cancer and its metastasis mechanism[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(3): 332-336.

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半枝莲抗结直肠癌及其转移机制研究进展

Research progress of Scutellaria barbata against colorectal cancer and its metastasis mechanism

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