中药提取物在脊髓损伤修复中的研究进展

doi:10.12092/j.issn.1009-2501.2019.09.018

摘要/Abstract

摘要：

脊髓损伤（spinal cord injury，SCI）作为一种致残率极高的中枢神经系统疾病，可导致患者损伤节段以下运动、感觉以及排泄功能的丧失。但是目前临床上尚无有效的治疗方案用来重建患者受损的神经功能。但是已有大量实验结果证实中药提取物可以作为重要的补充治疗方法改善脊髓损伤后神经功能修复与重建的效果。这种治疗作用可通过多种复杂的作用机制促进脊髓损伤后的损伤与修复反应。但目前涉及该领域的系统分析还不多见，因此本文就近几年有关单味中药提取物、中药单体以及复方中药提取物应用于脊髓损伤治疗中的研究进展进行一个较为全面的综述。

关键词: 脊髓损伤修复, 中药提取物, 氧化应激, 炎症反应

Abstract:

Spinal cord injury (SCI) is a highly debilitating central nervous system disease that usually results in loss of movement, sensation, and excretory function below the injured segment of the patient. However, there is currently no effective treatment in clinical practice to reconstruct damaged neurological function in patients. Through experimental research, Chinese herbal extracts can be used as an important complementary treatment to improve the neurological function and reconstruction after spinal cord injury. However, the systematic analysis involving this field is still rare. Therefore, this paper gives a comprehensive review of the research progress of traditional Chinese medicine extracts in the treatment of spinal cord injury in recent years.

Key words: spinal cord injury repair, traditional Chinese medicine extract, oxidative stress, inflammatory response

中图分类号:

鲁玉宝，陈昱橦，何格格，蔡宗晏，程岳，程子花，郭佳敏，郭艳芝. 中药提取物在脊髓损伤修复中的研究进展[J]. 中国临床药理学与治疗学, 2019, 24(9): 1075-1080.

LU Yubao, CHEN Yutong, HE Gege, CAI Zongyan, CHENG Yue, CHENG Zihua, GUO Jiamin, GUO Yanzhi. Application of traditional Chinese medicine extract in repairing spinal cord injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(9): 1075-1080.

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