内质网应激在心脏疾病中的研究进展

doi:10.12092/j.issn.1009-2501.2019.11.016

中国临床药理学与治疗学 ›› 2019, Vol. 24 ›› Issue (11): 1310-1314.doi: 10.12092/j.issn.1009-2501.2019.11.016

内质网应激在心脏疾病中的研究进展

王楷扬¹，李小丽^2,3，蔡永青⁴

¹中国人民解放军联勤保障部队第九二七医院药械科，普洱 665000，云南； ²重庆医科大学药学院药理学教研室，重庆 400016； ³重庆市高校生物化学与分子药理学重点实验室，重庆 400016；⁴陆军特色医学中心药剂科，重庆 400042

收稿日期:2019-06-18 修回日期:2019-09-11 出版日期:2019-11-26 发布日期:2019-12-02
通讯作者: 蔡永青，男，主管药师，主要从事抗炎免疫药理学研究。 Tel:023-68757092 E-mail:cy0721@163.com
作者简介:王楷扬，男，本科，药师，主要从事天然产物抗炎、抗肿瘤作用研究。 E-mail:408509991@qq.com
基金资助:
重庆市渝中区基础研究与前沿探索项目（20190102）；重庆科卫联合医学科研项目（2019MSXM010）；重庆市教育委员会科技研究项目（KJQN201800431）

Research progress of endoplasmic reticulum stress in heart diseases

WANG Kaiyang ¹, LI Xiaoli ^2,3, CAI Yongqing⁴

¹ Drug and Equipment Department,NO.927 Hospital,Joint Logistics Support Force of Chinese PLA,Puer 665000，Yunnan，China; ²Department of Pharmacology,College of Pharmacy,Chongqing University of Medical Sciences，Chongqing 400016，China; ³Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing 400016，China; ⁴Department of Pharmacy,Army Medical Center of PLA, Chongqing 400042，China

Received:2019-06-18 Revised:2019-09-11 Online:2019-11-26 Published:2019-12-02

摘要/Abstract

摘要：

内质网是胞内蛋白加工和修饰的重要细胞器，其为维持细胞内稳态和蛋白质质量控制会产生一系列反应，包含未折叠蛋白反应。内质网中未折叠或错误折叠蛋白大量累积，将进一步导致内质网应激，引起细胞和机体功能紊乱。近年研究发现，内质网应激相关信号通路与多种心脏疾病的发生发展高度相关。本文对内质网应激在缺血性心脏病、原发性心肌病、心肌肥大和心力衰竭的发生发展中的作用进行了综述。基于内质网应激在心脏疾病中的作用机制，可为通过靶向内质网应激治疗心脏疾病提供理论依据和应用手段。

关键词: 内质网应激, 心脏疾病, 靶向作用

Abstract:

Endoplasmic reticulum is an important organelle for intracellular protein processing and modification.It produces a series of reactions, including unfolded protein reactions, to maintain intracellular homeostasis and protein quality control.The accumulation of unfolded or misfolded proteins in endoplasmic reticulum will further lead to endoplasmic reticulum stress and cell and organism dysfunction.Recent studies have found that endoplasmic reticulum stress is highly related to the occurrence and development of various heart diseases.This article reviews the role of endoplasmic reticulum stress in the occurrence and development of ischemic heart disease,primary cardiomyopathy,myocardial hypertrophy and heart failure.Based on the mechanism of endoplasmic reticulum stress in cardiac diseases,it can provide theoretical basis and application means for the treatment of cardiac diseases by targeting endoplasmic reticulum stress.

Key words: endoplasmic reticulum stress, heart diseases, targeting

中图分类号:

R541

王楷扬，李小丽，蔡永青. 内质网应激在心脏疾病中的研究进展[J]. 中国临床药理学与治疗学, 2019, 24(11): 1310-1314.

WANG Kaiyang, LI Xiaoli, CAI Yongqing. Research progress of endoplasmic reticulum stress in heart diseases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(11): 1310-1314.

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内质网应激在心脏疾病中的研究进展

Research progress of endoplasmic reticulum stress in heart diseases

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