依布硒啉的药理作用及临床应用的研究进展

doi:10.12092/j.issn.1009-2501.2020.02.018

摘要/Abstract

摘要： 依布硒啉（ebselen，EbSe）是一种人工合成的脂溶性含硒有机小分子化合物，具有广泛的生理药理活性。EbSe作为含硒化合物的典型代表，研究者们对其展开了最为深入的研究。早期研究证明，EbSe能通过清除细胞内氧自由基，抑制脂质过氧化等过程维持多种组织的生理活性。近年来的研究发现，EbSe的含硒基团可影响底物的蛋白质半胱氨酸残基活性，使其潜在的应用范围不断扩大，并在人体多个系统的疾病治疗中表现出优良的潜在应用前景。此外，最新研究证实，EbSe还在对抗多重耐药菌的感染中显示出强大的活性。基于此，本文将EbSe多样的药理活性及其相关临床应用的最新研究进展进行简要综述，以期给科研与临床工作者提供一些参考。

Abstract: Ebselen (EbSe) is a synthetic lipo-soluble selenium-containing organic small molecule compound with a wide range of physiological and pharmacological activities. EbSe is one of the most well-studied selenium-containing compounds. Early studies have shown that EbSe possess various bio-activities by eliminating intracellular oxygen free radicals and inhibiting lipid peroxidation. Recent studies have demonstrated that the multifarious biological activities of EbSe based on its selenium effect on the cysteine residues of substrates. Its potential clinical application range keeps expanding, which has a prospect application in the treatment of multiple system diseases in the human body. In addition, the latest study confirmed that EbSe has outstanding antibacterial activity against multidrug-resistant bacteria infections. Based on this, this article briefly reviews the research progress of pharmacological activities and related clinical applications of EbSe, providing some references for scientific research and clinical workers.

中图分类号:

R969
R961

周靖轩，王朋，袁春玲，王君，邹黎黎. 依布硒啉的药理作用及临床应用的研究进展[J]. 中国临床药理学与治疗学, 2020, 25(2): 233-240.

ZHOU Jingxuan，WANG Peng，YUAN Chunling，WANG Jun，ZOU Lili. Research progress in pharmacological effects and clinical applications of ebselen[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(2): 233-240.

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