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中国临床药理学与治疗学 ›› 2021, Vol. 26 ›› Issue (2): 217-222.doi: 10.12092/j.issn.1009-2501.2021.02.014

• 综述与讲座 • 上一篇    下一篇

慢性肺曲霉菌病的治疗现状及展望

王娜娜1,谭效锋1,马涛2,程玉生3   

  1. 1天津市天津医院普内科,天津200040;2皖南医学院弋矶山医院手足踝外科,芜湖 241001,安徽;3皖南医学院弋矶山医院呼吸与危重症医学科,芜湖 241001,安徽

  • 收稿日期:2020-07-13 修回日期:2021-01-24 出版日期:2021-02-26 发布日期:2021-03-04
  • 通讯作者: 程玉生,男,博士,副主任医师,研究方向:肺部感染性疾病及呼吸危重症等。 Tel: 15156317597 E-mail: chengys1222@126.com
  • 作者简介:王娜娜,女,硕士,主治医师,研究方向:慢性阻塞性肺疾病及其并发症的诊断及综合治疗。 Tel: 13662034798 E-mail: 1984wangnana@163.com
  • 基金资助:
    国家自然科学基金(81301605);芜湖市科技攻关项目(2020dx1-3)

Current situation and future perspectives of treatment of chronic pulmonary aspergillosis

WANG Nana 1, TAN Xiaofeng 1, MA Tao 2, CHENG Yusheng 3   

  1. 1 Department of General Internal Medicine,Tianjin Hospital,Tianjin 200040, China; 2 Department of Hand and Foot Surgery, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui, China; 3 Department of Respiratory Medicine,Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui, China
  • Received:2020-07-13 Revised:2021-01-24 Online:2021-02-26 Published:2021-03-04

摘要: 慢性肺曲霉菌病(chronic pulmonary aspergillosis, CPA)是一种严重的肺部真菌感染性疾病,常导致肺结核、慢性阻塞性肺疾病和结节病等疾病复杂化,病死率高。目前,CPA的治疗策略主要包括药物治疗与手术治疗,治疗方案的选择应综合患者所患CPA的种类、临床表现和有无外科手术适应症等情况来决定。然而,迄今为止,临床实践中仍缺乏治疗CPA的标准方案。本文拟综述近年来CPA治疗领域的最新研究成果,总结CPA的治疗现状及进展。

关键词: 慢性肺曲霉菌病, 抗真菌治疗, 文献综述

Abstract: Chronic pulmonary aspergillosis (CPA) is a serious fungal infection, which complicates pulmonary tuberculosis, chronic obstructive pulmonary disease and sarcoidosis with high mortality. At present, the treatment of CPA include drug treatment and surgical treatment. The treatment plan should be determined by the type, clinical manifestations and surgical indications of the patients. Nevertheless, there is no standard plan, and more research is needed to improve it. Combined with the current literature reports, this article reviews the current and progress in the treatment of CPA.

Key words: chronic pulmonary aspergillosis, antifungal treatment, literature review

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