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中国临床药理学与治疗学 ›› 2023, Vol. 28 ›› Issue (1): 101-108.doi: 10.12092/j.issn.1009-2501.2023.01.013

• 综述与讲座 • 上一篇    下一篇

降糖药物与肌肉减少症关系的研究进展

蔡静1,2,潘斌晶1,2,刘靖芳2   

  1. 1兰州大学第一临床医学院,兰州 730000,甘肃;2兰州大学第一医院内分泌科,兰州 730000,甘肃
  • 收稿日期:2022-05-17 修回日期:2022-12-13 出版日期:2023-01-26 发布日期:2023-02-14
  • 通讯作者: 刘靖芳,女,博士,主任医师,博士生导师,研究方向:糖尿病及骨代谢相关病变。 E-mail: ljf824168@126.com
  • 作者简介:蔡静,女,在读硕士生,研究方向:糖尿病及骨代谢相关病变。 E-mail: 1322859280@qq.com
  • 基金资助:
    国家自然科学基金(81960155);甘肃省自然科学基金(20JR10RA690);兰州大学第一医院院内基金(ldyyyn2020-01)

Research progress on the relationship between hypoglycemic drugs and sarcopenia

CAI Jing1,2, PAN Binjing1,2, LIU Jingfang2   

  1. 1First College of Clinical Medicine, Lanzhou University, Lanzhou 730000, Gansu, China; 2Department of Endocrinology, First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China 
  • Received:2022-05-17 Revised:2022-12-13 Online:2023-01-26 Published:2023-02-14

摘要: 肌肉减少症是一种以肌肉质量减少、功能下降为特征的疾病,可以诱导跌倒、虚弱、死亡等不良事件。最新的研究显示许多降糖药物的使用与肌肉减少症相关,不同类型的降糖药物对于骨骼肌的质量和功能可能具有不同的作用和机制。本文就近年来关于降糖药物与肌肉减少症的关系及分子机制的研究进展作一综述,为临床上肌肉减少症的诊断和治疗预防提供参考。

关键词: 肌肉减少症, 降糖药物, 2型糖尿病

Abstract: Sarcopenia is a disease characterized by a decrease in muscle mass and function that can induce adverse events such as falls, weakness, and death. The latest research shows that the use of many hypoglycemic drugs is associated with sarcopenia. Different types of hypoglycemic drugs may have different effects and mechanisms for the quality and function of skeletal muscle. In this paper, we review the research progress of the relationship between hypoglycemic drugs and sarcopenia and the molecular mechanism in recent years to provide a reference for the diagnosis and treatment prevention of sarcopenia in clinical areas. 

Key words: sarcopenia, hypoglycemic drugs, type 2 diabetes

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