Methicillin-resistant staphylococcus aureus (MRSA) is one of the most common multi-drug resistant bacteria in clinical practice and is known as a "superbug". With the evolution of MRSA resistance mechanisms, it is increasingly difficult to treat MRSA infections with conventional antibiotics. In recent years, novel control strategies for MRSA infections have been developed at various levels. The unique structure of nanomaterials has antimicrobial activity and can also be used as an efficient transport carrier. Photodynamic therapy promotes cellular oxidative stress by light-activated photosensitizer (PS) interacting with molecular oxygen or substrates to generate reactive oxygen species (ROS). The antimicrobial properties of herbal medicines by multiple mechanisms have been widely demonstrated. Immunotherapy has made breakthroughs in the use of immune escape mechanisms, polyvalent vaccines, and mixed antibodies against MRSA. Gene targets represented by the mecA gene are being explored. Novel candidate antibacterial compounds targeting TDRS, especially the Trx system, will be a promising force in the future. In this paper, novel control strategies for MRSA are reviewed and prospected.

methicillin-resistant staphylococcus aureus, nanotechnology, photodynamic therapy, Chinese medicine therapy, immunotherapy, genetic strategies, novel candidate antibacterial compounds