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中国临床药理学与治疗学 ›› 2023, Vol. 28 ›› Issue (12): 1391-1402.doi: 10.12092/j.issn.1009-2501.2023.12.009

• 综述与讲座 • 上一篇    下一篇

高原低氧诱导肠稳态失衡的分子机制及中药防治研究进展

康  倩1，3，修明慧1，2，4，张雪燕4，杨  丹1，3，王树威4，和建政1，2，3，龚红霞1，2，3，曹旺杰1，2，3，苏  韫1，2，3
  

  1. 1甘肃中医药大学，甘肃省高校重大疾病分子医学与中医药防治研究重点实验室，兰州  730000，甘肃；2甘肃中医药大学，敦煌医学与转化教育部重点实验室，兰州  730000，甘肃；3甘肃中医药大学，基础医学院，兰州  730000，甘肃；4甘肃中医药大学，公共卫生学院，兰州  730000，甘肃
  • 收稿日期:2023-06-05 修回日期:2023-08-31 出版日期:2023-12-26 发布日期:2023-12-21
  • 通讯作者: 苏韫，硕士，教授，从事中西医结合防治肿瘤及高原低氧常见病的研究。 E-mail：suyungszy@126.com
  • 作者简介:康倩，女，在读硕士，从事中西医结合防治高原低氧相关疾病研究。 E-mail：15769342628@139.com
  • 基金资助:
    国家自然科学基金项目（82004228）；甘肃省自然科学基金（21JR11RA144）；2022年度甘肃省高等学校青年博士基金（2022QB-102）；甘肃省中医药管理局项目（GZKP-2021-32）

Molecular mechanism of high altitude hypoxia induced intestinal homeostasis imbalance and research progress of traditional Chinese medicine

KANG Qian1,3, XIU Minghui1,2,4, ZHANG Xueyan4, YANG Dan1, 3, WANG Shuwei4, HE Jianzheng1,2,3, GONG Hongxia1,2,3, CAO Wangjie1,2,3, SU Yun1,2,3    

  1. 1Gansu University of Traditional Chinese Medicine, Key Laboratory of Molecular Medicine and Traditional Chinese Medicine Prevention and Treatment of Major Diseases in Gansu Province, Lanzhou 730000,Gansu,China; 2Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities, Lanzhou 730000,Gansu,China; 3Gansu Zhongshan University of Medicine, School of Basic Medicine, Lanzhou 730000,Gansu,China; 4Gansu University of Traditional Chinese Medicine, School of Public Health, Lanzhou 730000,Gansu,China
  • Received:2023-06-05 Revised:2023-08-31 Online:2023-12-26 Published:2023-12-21

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摘要：

低氧是限制人群在高原生存的因素之一，能够引起呕吐腹泻、心慌气短、急性昏迷等症状。患有急性高原病的人约80%至少有一种胃肠道不适的症状，如厌食、恶心、腹泻、呕吐等。研究高原低氧所致肠损伤的病理特点、发病机制及药物防治，有利于高原胃肠道疾病的诊治。因此，本文通过总结相关文献，就高原低氧造成肠道损伤的相关研究进行系统阐述，对高原低氧造成肠道形态学、肠道细胞、肠道菌群等肠稳态的改变，引起肠道炎症、氧化损伤等机制及中药防治进行总结，以期为科研工作者和临床工作者提供借鉴及信息参考。

关键词: 高原低氧, 肠稳态失衡, 抗缺氧, 炎症, 氧化损伤

Abstract:

Hypoxia is one of the factors restricting the survival of people at high altitudes, which can cause various symptoms such as vomiting, diarrhea, palpitations, shortness of breath and acute coma. About 80% of patients with acute mountain sickness have at least one symptom of a gastrointestinal distress (e.g., anorexia, nausea, diarrhea, vomiting, etc.). The pathological characteristics, pathogenesis and drug treatment of intestinal injury caused by high-altitude hypoxia were studied, which is conducive to the diagnosis and treatment of plateau gastrointestinal diseases. Therefore, by summarized relevant literature and systematically expounds the related researches on intestinal damage caused by high altitude hypoxia. We summarized the changes of intestinal morphology, intestinal cells, intestinal flora and other intestinal homeostasis caused by high altitude hypoxia, the mechanism of intestinal inflammation and oxidative damage, and the treatment of traditional Chinese medicine, which provide reference and information for reference for scientific research workers and clinicians.

Key words: high-altitude hypoxia, intestinal homeostasis imbalance, anti-hypoxia, inflammation, oxidative damage

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