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中国临床药理学与治疗学 ›› 2024, Vol. 29 ›› Issue (9): 1042-1048.doi: 10.12092/j.issn.1009-2501.2024.09.010

• 综述与讲座 • 上一篇    下一篇

丙泊酚对肿瘤生长和转移机制影响的研究进展

金宝伟1，王凯1，郭建荣2   

  1. 1绍兴市人民医院麻醉科，绍兴  312000，浙江；2海军军医大学附属公利医院麻醉科，上海  200135

  • 收稿日期:2023-11-09 修回日期:2024-01-05 出版日期:2024-09-26 发布日期:2024-08-21
  • 通讯作者: 郭建荣，通信作者，男，博士，博士后，主任医师、教授，博士生导师，研究方向：麻醉基础与临床。 E-mail：jianrguo@126.com
  • 作者简介:金宝伟，男，硕士，主治医师，研究方向：麻醉基础与临床。 E-mail：baoweijin1981@163.com
  • 基金资助:
    浙江省公益技术应用研究资助项目（LGD22H160011）

Research progress on the effects of propofol on tumor growth and metastasis mechanism

JIN Baowei1, WANG Kai1, GUO Jianrong2   

  1. 1 Department of Anesthesiology, Shaoxing People's Hospital, Shaoxing 312000, Zhejiang, China; 2 Department of Anesthesiology, Shanghai Gongli Hospital, Naval Military Medical University, Shanghai 200135, China
  • Received:2023-11-09 Revised:2024-01-05 Online:2024-09-26 Published:2024-08-21

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摘要：

丙泊酚作为广泛应用的静脉麻醉药，近年来研究发现其具有抗肿瘤生长和转移的潜能。目前对丙泊酚抑制肿瘤生长和转移相关机制的研究仍相对有限。本文就近年来丙泊酚在抑制肿瘤生长和转移过程中的作用及其可能的分子机制，如调控特定信号通路或关键分子，以及与其他分子间的相互作用等研究进行初步总结。同时，就丙泊酚的应用，包括优化给药途径和剂量，以及作为放疗、化疗的辅助治疗等方面的可能性进行了分析，并就近年来丙泊酚抑制肿瘤生长和转移机制的研究作一综述，为进一步探索丙泊酚在临床抗肿瘤生长和转移治疗中的应用和研究方向提供参考。

关键词: 丙泊酚, 肿瘤, 转移机制, 通路

Abstract:

Propofol, as a widely used intravenous anesthetic, has been found to have the potential of anti-tumor growth and metastasis in recent years. At present, the research on the mechanism of propofol inhibiting tumor growth and metastasis is still relatively limited. In this paper, we summarize the recent studies on the role of propofol in inhibiting tumor growth and metastasis and its possible molecular mechanisms, such as regulating specific signaling pathways or key molecules, and interacting with other molecules. At the same time, the application of propofol, including the optimization of administration route and dose, as well as the possibility of being an adjunct therapy to radiotherapy and chemotherapy, was analyzed, and the recent studies on the mechanism of propofol inhibiting tumor growth and metastasis were reviewed,providing a reference for further exploration of the application and research direction of propofol in clinical anti-tumor growth and metastasis therapy.

Key words: propofol, tumor, transfer mechanism, passage

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