维生素D对子宫内膜异位症发病的影响机制

doi:10.12092/j.issn.1009-2501.2026.05.017

中国临床药理学与治疗学 ›› 2026, Vol. 31 ›› Issue (5): 716-720.doi: 10.12092/j.issn.1009-2501.2026.05.017

• 综述与讲座 • 上一篇

维生素D对子宫内膜异位症发病的影响机制

张群¹(), 石慧², 戴玲玲³, 高晶晶³^,*()

1. 南京大学医学院附属鼓楼医院妇产科，南京 210000，江苏
2. 上海交通大学医学院附属瑞金医院风湿免疫科，上海 200025
3. 射阳县人民医院妇产科，射阳 224300，江苏

收稿日期:2024-12-22 修回日期:2025-05-16 出版日期:2026-05-26 发布日期:2026-06-02
通讯作者: 高晶晶 E-mail:yuanxiao-0223@163.com;ghfgfl@163.com
作者简介:张群，女，博士，主治医师，研究方向：卵巢功能早衰，卵巢子宫内膜异位症的防治。E-mail：yuanxiao-0223@163.com
基金资助:
2024年度盐城市基础研究计划（自然科学基金）（YCBK2024103）

Research progress on the mechanism of vitamin D expression in the pathogenesis of endometriosis

Qun ZHANG¹(), Hui SHI², Lingling DAI³, Jingjing GAO³^,*()

1. Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210000, Jiangsu, China
2. Department of Rheumatology and Immunology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
3. Department of Obstetrics and Gynecology, Sheyang County People's Hospital, Sheyang 224300, Jiangsu, China

Received:2024-12-22 Revised:2025-05-16 Online:2026-05-26 Published:2026-06-02
Contact: Jingjing GAO E-mail:yuanxiao-0223@163.com;ghfgfl@163.com

摘要/Abstract

摘要：

子宫内膜异位症（endometriosis，EMT）是临床发病率较高的妇科疾病，痛经、盆腔痛为主要症状，发病与免疫应答、炎症、细胞增殖凋亡密切相关。近几年有研究发现维生素D对骨代谢、钙磷平衡、细胞凋亡等具有调控作用，并且参与慢性炎性疾病、免疫疾病以及肿瘤疾病发病过程。本文从免疫应答、炎症反应、细胞增殖凋亡分析维生素D参与EMT发病过程的作用机制及其临床诊断、治疗应用成效。结果发现免疫应答、炎症反应、细胞增殖凋亡是维生素D参与EMT发生与病情进展的主要机制，对EMT发生、发展及妊娠结局显示出潜在的预测价值，可以为内异症的无创治疗提供新思路与方向。

关键词: 维生素D, 子宫内膜异位症, 发病机制, 诊断, 治疗, 综述

Abstract:

Endometriosis (EMT) is a gynecological disease with high clinical incidence, with dysmenorrhea and pelvic pain as the main symptoms. The pathogenesis is closely related to immune response, inflammation, cell proliferation and apoptosis. In recent years, studies have found that vitamin D has regulatory effects on bone metabolism, calcium and phosphorus balance, and apoptosis. It is also involved in the pathogenesis of chronic inflammatory diseases, immune diseases and tumor diseases. This article analyzes the mechanism of vitamin D in the pathogenesis of EMT and its clinical diagnosis and treatment application effect from immune response, inflammatory response, cell proliferation and apoptosis. The results showed that immune response, inflammatory response, cell proliferation and apoptosis were the main mechanisms of vitamin D involved in the occurrence and progression of EMT, which had certain predictive value for the occurrence, development and pregnancy outcome of EMT, which could be used as a new idea and target for non-invasive treatment for endometriosis.

Key words: vitamin D, endometriosis, pathogenesis, diagnosis, treatment, review

中图分类号:

R711.71

张群, 石慧, 戴玲玲, 高晶晶. 维生素D对子宫内膜异位症发病的影响机制[J]. 中国临床药理学与治疗学, 2026, 31(5): 716-720.

Qun ZHANG, Hui SHI, Lingling DAI, Jingjing GAO. Research progress on the mechanism of vitamin D expression in the pathogenesis of endometriosis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(5): 716-720.

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维生素D对子宫内膜异位症发病的影响机制

Research progress on the mechanism of vitamin D expression in the pathogenesis of endometriosis

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