转录因子Bach1在肺疾病中的研究进展

doi:10.12092/j.issn.1009-2501.2026.09.013

摘要/Abstract

摘要：

BTB-CNC同源体1（BTB and CNC homology 1，Bach1）是碱性亮氨酸拉链蛋白家族的重要转录抑制因子，广泛存在于哺乳动物的各种组织中，在氧化应激、血红素代谢、铁死亡、血管生成、血管重构、表观遗传修饰、糖酵解和线粒体功能等关键生物学过程中发挥重要作用。本文主要就Bach1在肺疾病中的研究进展进行综述，以期为进一步研究Bach1在肺疾病中的调控机制提供新的思路，并探讨其作为治疗靶点的潜在应用价值。

关键词: BTB-CNC同源体1, 转录因子, 肺疾病

Abstract:

BTB and CNC homology 1 (Bach1), a crucial transcriptional repressor within the basic leucine zipper protein family, is ubiquitously expressed across various mammalian tissues. It plays significant roles in key biological processes such as oxidative stress, heme metabolism, ferroptosis, angiogenesis, vascular remodeling, epigenetic modification, glycolysis and mitochondrial function. This article primarily reviews the research progress of Bach1 in lung diseases, aiming to provide new insights for further investigation into its regulatory mechanisms and to explore its potential value as a therapeutic target.

Key words: BTB and CNC homology 1, transcription factors, lung diseases

中图分类号:

R563
R363

马爱, 李晓凤, 刘晓菊. 转录因子Bach1在肺疾病中的研究进展[J]. 中国临床药理学与治疗学, 2026, 31(9): 1265-1274.

Ai MA, Xiaofeng LI, Xiaoju LIU. Research progress of transcription factor Bach1 in lung diseases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(9): 1265-1274.

图/表 3

图 1 BTB-CNC同源体1的基本结构

Fig.1 Schematic diagram of basic structure of BTB-CNC homology 1

图 2 与Bach1蛋白相关的肺疾病

Fig.2 Lung diseases associated with Bach1 protein

图 3 Bach1在主要肺疾病中的作用机制及靶向Bach1的治疗策略

Fig.3 The mechanism of Bach1 in major lung diseases and therapeutic strategies targeting Bach1

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