性激素类药物诱发胆囊结石的实验研究

中国临床药理学与治疗学 ›› 1996, Vol. 1 ›› Issue (1): 29-30.

性激素类药物诱发胆囊结石的实验研究

王成友, 余宏铸, 张薇薇

安徽医科大学第一附属医院,合肥 230022

收稿日期:1996-03-16 修回日期:1996-05-06 出版日期:1996-03-26 发布日期:2020-12-03
作者简介:王成友,普外科副主任,主任医师,教授,享受国务院特殊津贴,有突出贡献的中青年科技专家。

The experimental study on forming of gallstone induced by drugs of sex hormone

Wang Chenyou, Yu Hongzhui, Zhang Weiwei

First Affiliated Hospital, Anhui Medical University, Hefei 230022

Received:1996-03-16 Revised:1996-05-06 Online:1996-03-26 Published:2020-12-03

摘要/Abstract

摘要： 目的探索性激素类药物诱发胆囊结石的关系。方法用大白免60只,分6组,给予雌二醇、孕酮、睾酮、绒毛膜促性腺激(HCG),ip, 设生理盐水和精茶油对照组。实验时间6周,处死检测血液、胆汁、胆囊、胆管、肝脏及胆石。结果雌二醇组90%成石; HCG组内雌性兔100%成石,雄性兔无结石形成;孕酮组无结石,睾酮组仅1例胆囊结石,两对照组均无结石。成石为胆固醇性结石。结论性激素类药物中,雌二醇、HCG与胆囊胆固醇结石的形成有关。

关键词: 性激素, 胆囊, 胆石病, 病因学

Abstract: Aim To know whether the sex hormone played a role in formation of gallstone, the experimental study on the drugs was designed. Methods 60 rabbits were randomly divided into 6 groups in 4 of which(groups E₂,P,T,H) estradiol,progesterone,testosterone and HCG were administered separately, and normal saline and refined oil were given to as control in the other groups(C₁、C₂). The animals were put to death in 6 weeks. The blood, bite, gallbladder, bile duct, liver and gallstones were assayed. Results The gallstone formation rate was 90% in group E₂,50% in group H and 10% in group T. There no gallstone that was formed in the alimals in groups P, C₁ and C₂. Most of the gallstones were found in the female animals. Only in group E₂ were the gallstones found in 4 male rabbits. The comnpostion of stone was mainly choles-terol. Conclusion Among the sex hormones estradiol and HCG are in relation to the formation of gallbladder cholestrol stone.

Key words: Sex hormone, Gallbladder, Gallstone, Aetiolgy

中图分类号:

R972.3

王成友, 余宏铸, 张薇薇. 性激素类药物诱发胆囊结石的实验研究[J]. 中国临床药理学与治疗学, 1996, 1(1): 29-30.

Wang Chenyou, Yu Hongzhui, Zhang Weiwei. The experimental study on forming of gallstone induced by drugs of sex hormone[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1996, 1(1): 29-30.

[1]	王叶情, 王宇红, 刘检, 赵洪庆, 邹蔓姝. 胆囊收缩素与抑郁症的相关性研究进展[J]. 中国临床药理学与治疗学, 2021, 26(6): 672-679.
[2]	桂华，曹珊珊，赵巧云，王佩红. 克龄蒙联合戈舍瑞林对子宫内膜异位症患者腹腔镜术后血清激素水平的影响[J]. 中国临床药理学与治疗学, 2018, 23(5): 557-560.
[3]	魏锋，王大禹，魏云海. 疏肝柴胡散对胆囊切除术后综合征的临床疗效及安全性[J]. 中国临床药理学与治疗学, 2017, 22(3): 316-320.
[4]	邓潇斐, 罗非, 郭建友. 反安慰剂效应及其内在机制[J]. 中国临床药理学与治疗学, 2015, 20(5): 591-596.
[5]	贾建光，郭晨旭，李靖，张立功，王益民，全志伟，钱军. 腺病毒介导的MDA-7/IL-24基因对裸鼠胆囊癌移植瘤的生长抑制和促凋亡作用[J]. 中国临床药理学与治疗学, 2015, 20(11): 1221-1226.
[6]	林忠, 孙渊, 杜有功, 杨建苗, 林建群. 染料木黄酮植物性雌性激素治疗骨质疏松研究进展[J]. 中国临床药理学与治疗学, 2014, 19(1): 105-111.
[7]	张林, 李茂岚, 李松岗, 吴文广, 刘颖斌. 胆囊癌淋巴转移分子机制研究进展[J]. 中国临床药理学与治疗学, 2012, 17(8): 919-923.
[8]	耿武军, 唐红丽, 张学政, 黄陆平, 高小燕. 地佐辛注射液对腹腔镜胆囊切除术全麻苏醒期不良反应的影响[J]. 中国临床药理学与治疗学, 2012, 17(3): 318-321.
[9]	陈玲阳, 彭从斌, 王惠琴. 地塞米松联合肋间神经阻滞对腹腔镜胆囊切除术患者术后疼痛及恢复的影响[J]. 中国临床药理学与治疗学, 2009, 14(12): 1406-1409.
[10]	阚红卫, 魏安祥. 胆囊炎病因及其动物模型研究进展[J]. 中国临床药理学与治疗学, 2008, 13(8): 957-960.
[11]	喻君, 郭建荣, 金孝岠. 氯诺昔康与布托啡诺用于腹腔镜胆囊切除术后镇痛效果[J]. 中国临床药理学与治疗学, 2008, 13(3): 340-343.
[12]	王欣, 刘新民. 惊恐障碍的病因及治疗进展[J]. 中国临床药理学与治疗学, 2008, 13(1): 25-30.
[13]	潘维敏, 王世端, 余芸芸, 王士雷. 利多卡因对腹腔镜手术病人应激反应的影响[J]. 中国临床药理学与治疗学, 2007, 12(3): 357-360.
[14]	李济宇, 全志伟, 张强, 刘建文. 生长抑素增强胆囊癌细胞化疗敏感性的研究[J]. 中国临床药理学与治疗学, 2004, 9(2): 171-176.
[15]	陆仁康, 彭守静, 哀德祥, 秦进喜, 徐岚, 朱其荪. 右旋普蔡洛尔对家兔和大鼠阴道内用药的耐受性及其对血糖、脂代谢和性激素水平的影响[J]. 中国临床药理学与治疗学, 1997, 2(1): 5-7.