右旋普蔡洛尔对家兔和大鼠阴道内用药的耐受性及其对血糖、脂代谢和性激素水平的影响

中国临床药理学与治疗学 ›› 1997, Vol. 2 ›› Issue (1): 5-7.

右旋普蔡洛尔对家兔和大鼠阴道内用药的耐受性及其对血糖、脂代谢和性激素水平的影响

陆仁康, 彭守静, 哀德祥¹, 秦进喜¹, 徐岚², 朱其荪³

皖南医学院生殖医学研究所, 芜湖 241001;
¹天津市计划生育研究所, 天津 300191;
²汕头大学医学院附一院, 汕头 515031;
³芜湖市妇幼保健院, 芜湖 241001

收稿日期:1997-01-28 出版日期:1997-03-26 发布日期:2020-12-04
作者简介:陆仁康,男,教授,国际男性学会会员,皖南医学院生殖医学研究所所长,卫生部全国妇幼卫生/计划生育专家指导组成员,中国性学会常务理事,中国生殖生物学会理事,中国男性学会理事,有突出贡献的中青年专家,享受国务院特殊津贴专家。主要研究:生殖医学,生育调节,性功能降碍诊治。
基金资助:
本课题系安徽省八五攻关项目

Tolerance test of D-propranolol and its effect on sugar, lipid metabolism and sex hormone levels by intravaginal administration in rats and rabbits

Lu Renkang, Pang Shoujing, Yuan Dexiang¹, Qin Jinxi¹, Xu Lan², Zhu Qisun³

Institute of Reproductive Medicine Research, Wannan Medical College, Wuhu 241001;
¹Tianjin Municipal Research Institute for Family planning, Tianjin 300191;
²The First Hospital, Shantou University Medical College, Shantou 515031;
³Wuhu Munic-ipal Maternity and Child Health Hospital, Wuhu, 241001

Received:1997-01-28 Online:1997-03-26 Published:2020-12-04

摘要/Abstract

摘要： 目的研究国产右旋普蔡洛尔(D-porparnolol,D-P)阴道内给药对家兔和大鼠的衬受性及其对血糖,脂代谢和性激素水平的影响。方法家兔组: 12只家兔分4组,3只予以D-P栓剂(每个栓剂含D-P60mg和适量的基质聚乙二醇 1000)阴道内插入给药,每天一次,连续10天,并与阳性对照组(氛胺),阴性对照组(单纯机械刺激)和基质组(聚乙二醉)作比较;大鼠组: 12只大鼠给予阴道内注入D-P 0.2ml(40mg/ml) 每日一次,连续56天,每2周采血一次,测血糖、血脂和性激素浓度(E₂,P,LH,FSH)。实验结束后,立即处死动物,解剖阴道,用肉眼和显微镜检查阴道组织受损情况。结果在家兔组未见阴道组织有异常损害,与正常对照组比较无明显差异(P>0.05),大鼠组可见阴道组织有轻微充血、水肿,但均在可耐受评分值内,对血糖血脂和性激素水平均无明显影响。结论国产D-P阴道内给药对家兔和大鼠均无明显影响,说明阴道内给药是安全的。

关键词: 右旋普蔡洛尔, 血糖, 脂蛋白代谢, 性激素

Abstract: Aim To study the tolerance of D-propranolol and is effect on sugar lipid metabolism and sex hormone levels by intravaginal administration in rats and rbbits.Methods 1.Rabbit group:three rabbits were given D-propranolol suppository (each suppository contain D-propranolol 60mg and opporture amount polyethanediol)by vaginal insertion, q.d. for 10 days. 2.Rat group:12 rats were given D-propranolol solution (40mg/ml)0.2 ml by direct injection into rat vagina q.d. for 56 days and blood samples were collected for measurement of blood sugar, lipids and sex hormone levels every 2 weeks.Immediately after killing all subject animals.Vaginal tissues were examined by macroscopy and microscopy.Results In the rabbits and rats group, no marked lesions of vaginal tissues were observed and the tissues did not significantly differ from those in the control group (P>0.05)and in rats group were slightly affected, i.e.mucosa edema and /or congestion but all those changes could be tolerated ,and there were no changes in blood sugar, lipids and sex hormones after treatmetn with D-propranolol for 8 weeks.Conclusions The results suggested that D-propranolol is safe when used in vagina.

Key words: D-propranolol, carbohydrates, lipoprateins, sex hormone

中图分类号:

R979.21

陆仁康, 彭守静, 哀德祥, 秦进喜, 徐岚, 朱其荪. 右旋普蔡洛尔对家兔和大鼠阴道内用药的耐受性及其对血糖、脂代谢和性激素水平的影响[J]. 中国临床药理学与治疗学, 1997, 2(1): 5-7.

Lu Renkang, Pang Shoujing, Yuan Dexiang, Qin Jinxi, Xu Lan, Zhu Qisun. Tolerance test of D-propranolol and its effect on sugar, lipid metabolism and sex hormone levels by intravaginal administration in rats and rabbits[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1997, 2(1): 5-7.

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