非成瘾性镇痛剂丙帕他莫与盐酸哌替啶治疗中等手术后疼痛的双盲对比研究

中国临床药理学与治疗学 ›› 1999, Vol. 4 ›› Issue (1): 6-11.

非成瘾性镇痛剂丙帕他莫与盐酸哌替啶治疗中等手术后疼痛的双盲对比研究

蒋朱明, 于布为², 曹金铎³, 马恩陵, 刘佳

中国医学科学院北京协和医院临床药理中心,北京 100730;
肠外物内营养与外科用药专业组
²上海第二医科大学瑞金医院,³卫生部北京医院

收稿日期:1998-12-03 修回日期:1998-02-23 出版日期:1999-03-26 发布日期:2020-12-03
作者简介:蒋末明,教授,男,从事旸外肠内营养用药及外科用药的临床研究

A controlled double-blind study on the analgesic effect of the none-addictive propacetamol HCl on Moderate postoperative pain

JIANG Zhu-Ming, YU Bu-Wei², CAO Jin-Duo³, MA En-Ling, LIU Jia

ParenteraL and Enteral Nutrition and Surgical Medication Group;
Clinical pharmacology Center of Peking Union Medical College Hospital Peking 100730;
²Shanghai Reijin Hospital;
³Beijing Hospital

Received:1998-12-03 Revised:1998-02-23 Online:1999-03-26 Published:2020-12-03

摘要/Abstract

摘要： 目的评价非成瘾性镇痛剂丙帕他莫与度冷丁治疗中等手米后疼痛的效果。方法 120名(年龄18~75岁）接受腹部外科,妇科及矫形外科手术后疼痛达到中度或重度的病人参加本研究。研究组用盐酸丙帕他莫（propacetamol HCl) 2g溶解稀释静脉滴注,在静脉滴注时肌注生理盐水1.0 ml;对照组用甘露醇（用作安慰剂,dummy drug) 1.6 g溶解稀释静脉满注,在静脉滴注开始时肌注盐酸哌替啶（dolantin用作对照）50 mg (1.0 ml)。按随机双盲原则进行治疗,每个病例的用药观察期为6小时。结果与结论 研究期间均未出现B月显不良反应,也无皮疹发生。按盲后显示盐酸丙帕他莫和盐敢哌替啶具有相似的安全性和有效袪。但盐敢丙帕他莫不具有成瘾性,作为中等手术后镇痛药有广泛的应用前景。

关键词: 非成瘾性镇痛剂, 普鲁百服宁, 盐酸丙帕他莫, 术后疼痛

Abstract: Aim To compare the analgesic effect of the noneaddictive Propacetamol HCl with that of Dolantin (Pethidine HCl) on moderate postoperative pain. Methods 120 patients aged 18~75 years old were enrolled in this study, whose postoperative pain reached moderate to severe level after abdominal surgery, gynecol6gic surgery or orthopedic surgery. In the study group,2 g Propacetamol HCl was diluted and infused intravenously while at the same time 1.0 ml saline was injected intramuscularly; in the control group, 1.6 g mannitol as dummy drug was diluted and infused intravenously while at the same time 50 mg (1.0 ml) Dolantin was injected intramuscularly. Treatment was carried out randomly and double-blindly with the observation period of 6 hr in each case. Results & Discussion There was no obvious adverse reaction or erythra during the study period. After decoding as planed, it was shown that Propacetamol HCl and Pethidine HCl had the similar safety and efficacy. Since propacetamol HCl is none-addictive, it will have a future of wide application as analgesic for moderate postoperative pain.

Key words: none-addictive analgesic, Pro-Bufferin, propacetamol, postoperative pain

中图分类号:

R971.3

蒋朱明, 于布为, 曹金铎, 马恩陵, 刘佳. 非成瘾性镇痛剂丙帕他莫与盐酸哌替啶治疗中等手术后疼痛的双盲对比研究[J]. 中国临床药理学与治疗学, 1999, 4(1): 6-11.

JIANG Zhu-Ming, YU Bu-Wei, CAO Jin-Duo, MA En-Ling, LIU Jia. A controlled double-blind study on the analgesic effect of the none-addictive propacetamol HCl on Moderate postoperative pain[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1999, 4(1): 6-11.

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