关键词: 脑络通, 血脂, 动脉粥样硬化, 鹌鹑

Abstract: Aim The effects of Naoluotong, a cempeund of Chinese medicine on atherosclerosis were studied.Methods One hundred and twenty male quails were divided at random into 6 groups.The quaits in 5 groups, including the control group,Naoluotong (3, 6, 12 g·kg^-1·d^-1)groups, and Yuejiancao oil (6 g·kg^-1·d^-1)group, received hyper-f at forage, and in the six th group were fed on stock diet.Half of the quails in each group were kill 4 wk after.The levels of TC, TG, LDL-C,V LDL-C and HDL-C in serum were measured in Biochemilal method.The remainder quails were fed on above forege continuously for another 4 wk and then were killed.The levels of TC, TG, LDL-C,V LDL-C and HDL-C in serum and the contents of TC and TG in myocardium and aorta were tested, and the change of endo-aorta was determined.Results The levels of TC, TG, LDL-C and V LDL-C were decreased, the level of HDL-C and the v atio of HLD-C/TC were increased by Naoluotong (6, 12 g·kg^-1·d^-1)in the quails fed on hyper fat forage for 4wk (P<0.05, P<0.01).In the remainder quails which were raised for 8wk, the above items were similar to the quails fed for 4wk, the effelts of Naoluotong was dose-d ependent in adjusting blood lipid, and the contents of TC and TG in aorta and myo cardium were decreased (P<0.05)and the lesion of endo-aorta was also improved by Naoluotong (6, 12 g·kg^-1·d^-1). Conclusion Naoluotong has the action to adjust blood lipid-adjusting and to antag ouise atherosclerosis.

Key words: Naoluo tong, serum lipid, atherosclerosis, quail