关键词: 全胃肠外营养, 乙基西梭霉素, 药代动力学, HPLC-IPD

Abstract: Aim The pharmacokinetics of netilmicin(NTM)in the patients receiving total parenteral nutrition (TPN)was studied.Methods Seven patients with intestines fistula under TPN and seven patients in control group received 5 mg · kg of NTM by iv infusion in 0.5 h.NTM concent rations in serum and urine were determined by a high performance liquid chromatog raphy-indirect photometric determination (HPLC-I PD)method.Pharmaco kinetics parameters were computed with the 3p87 program.Results After intravenous administration of NTM 5 mg ·kg^-1, the NTM chromatog raphy peakconcent ration in serum was insignificantly lower in the TPN group than that in the control group (P>0.05), but the N TM level in the TPN group became higher than that in the control group (P>0.05)at 5th hour and significantlyhig her at 12 th hour after beg inning of administration (P<0.05).The reclamations of original shape NTM in urine were (52±13)% in the TPN group and (63±13)% in the control group. Pharmacokinetics calculations were disposed to two-compartment open-system model with t_1/2(β)=(5.8±1.6)h, Vc =(0.47±0.15)L · kg^-1 in TPN and t_1/2(β)=(3.5±1.4)h, Vc =(0.28±0.09)L ·kg^-1 in the control.Conclusion There is a marked drop in the removing rate of N TM from body.

Key words: total parenteral nutrition, natilmicin, pharmacokinetics, high performance liquid chromatog raphy-indirect photometric determination