关键词: 呋塞米, 在体鼻重循环法, 鼻腔吸收, 薄荷醇

Abstract: Aim The nasal absorption of furosemide and promotion action of l-menthol was ex amined.Methods In situnasal recirculation methods was used to study the does-effect relationship of nasal absorption of furosemide and the effect of l-menthol on nasal absorptionof furosemide in rat s.Results When the concentration of furosemide in circulation liquid was respectively (4.66±0.33)、(9.76±0.45)and (18.83±1.89)μg·ml^-1,the absorption rate constant k (min^-1)of nasal insitu was correspondingly 0.0067±0.0011,0.0134±0.0024 and 0.0163±0.0037;and urine liquid appearing time was (73.33±1.53)、(52.67±7.02) and (47.00±4.58)min.But the larger the concentrationofl-menthol,the little the absorption rate constant k.Conclusion Furosemide can be absorbed through the nasal mucous,and l-menthol can promote its absorption.

Key words: furosemide, In situ nasal recirculation method, nasal absorption, l-menthol