化学修饰后的四环素对牙周疾病、关节炎/风湿性关节炎、恶性肿瘤及骨质疏松的作用

中国临床药理学与治疗学 ›› 2000, Vol. 5 ›› Issue (1): 79-86.

化学修饰后的四环素对牙周疾病、关节炎/风湿性关节炎、恶性肿瘤及骨质疏松的作用

徐静文¹, 徐梅², Greenwald RobertA³

美国阿伯特·爱因斯坦医学院长岛医疗中心风湿科,纽约 11040

收稿日期:1999-12-11 出版日期:2000-03-26 发布日期:2020-11-26
作者简介:1 徐静文,博士,研究员;2 徐梅,博士生,芬兰赫尔辛基大学生物医学学院药理毒理研究所;3 Greenwald Robert A,教授,美国阿伯特· 爱因斯坦医学院长岛医疗中心风湿科。

Effects of chemically modified tetracyclines (CMTs)on osteoarthritis/rheumatoid arthritis,periodontal disease,cancer,and osteoporosis

Received:1999-12-11 Online:2000-03-26 Published:2020-11-26
Contact: 1 Dr.XU Jing-Wen(MD,PhD),Divi sion of Rh eumatology,Lo ng Islan d J ewi sh Medical Center,The Long Island Campus for th e Albert Ein stein College of Medicine,New Hyde Park,New York 11040,USA ;2 Department of Pharmacology and To xicology,In sti tute of Biomedicine,Universi ty of Helsinki,Finland ;3 Division of Rheumatology,Long Island Jewish M edical Center,Th e Lon g Island Campus for the Albert Ein stein College of Medicine.E-mail:xujingwen @yahoo.com

摘要/Abstract

摘要： 四环素是1948 年发现的一种广谱抗生素,在治疗上已得到广泛应用。目前发现它还有一种与核糖体蛋白合成无关的新用途,本文就化学修饰后的四环素对牙周疾病、关节炎/风湿性关节炎、恶性肿瘤及骨质疏松的作用作一综述。

徐静文, 徐梅, Greenwald RobertA. 化学修饰后的四环素对牙周疾病、关节炎/风湿性关节炎、恶性肿瘤及骨质疏松的作用[J]. 中国临床药理学与治疗学, 2000, 5(1): 79-86.

1 Wainwrigh M.Miracle cure,the story of antibi-otics.Cambridge,MA:Basil Blackw ell Ltd,1990;152
2 Lambert HP,O'Grady FW.Antibiotic and chemo-therapy.Finch RG,Mandragoe K (eds).Tetracy-clines.Edinburgh.Churchill Living stone,1992:277
3 Golub LM,Lee HM,Lehrer G,et al.Minocy cline reduces gingival collagenoly ticactivity during dia-betes:preliminary observations and a proposed new mechanism of action.J Periodont Res,1983;18:516
4 Golub L,McNamar a TF,D'Angelo G,et al.A non-antibacterial chemically-modified tetracycline in-hibits mammalian collagenase activity.J Dent Res,1987;66:1310
5 Golub L,Ramamurthy N,McNamara T,et al.Te-tracyclines inhibit connective tissue breakdown:new therapeutic implications for an old family of drug s.Cr it Rev Oral Biol Med,1991;2:297
6 Greenw ald RA,Golub LM,Ramamurthy NS,et a l.In vitro sensitivity of the three mammalian collage-nases to tetracycline inhibition:relationship to bone and cartilagedegradation.Bone,1998;22:33
7 Greenwald RA,Golub LM:P erface,Adv Dent Res,1998;12:1
8 Birkedal-Hansen H,Moore E,Bodden M K,et al.M atrixmetall oproteinases:are view.Crit Rev OralBiol Med,1993;4:197
9 Murphy G,Knauper V.Relating matrix metallo proteinase structure to funcation:why the“hemopex in”domain?Matrix Biol,1997;15:511
10 Gomez DE,Alonso DF,Yoshiji H,et al.Tissue in-hibitors of me talloproteinases:structure,regulation and biological functions.Eur J Cell Biol,1997;74:111
11 Johnson LL,Dye r R,Hupe DJ.Ma trix metallopro-teinases.Cur r Opin Chem Bio l,1998;2:466
12 Becket t R,Whittaker M.Matrixme tallopr oteinase inhibitors1998.Exp Opin Ther Patents,1998;8:259
13 Pelletier JP,Martel-Pelle tier J,Howell DS.E-tiopathogenesis of osteoar thritis.In:Koopman WJ,editor.Ar thritis and allied conditions:atextbook of reheumatology.13 thed.Baltimore:Williams&Wilkins,1997:1969
14 Westhoff CS,Freudiger D,Petrow P,et al.Char-a cterization of collagena se3 (mat rix me tallopro teinase13)messenger RNA expression in the syn-ovialmembrane and synovial fibroblasts of patients with rheumatoid arthritis.Arthritis Rheum,1999;42:1517
15 ColeAA,Yi X-W,Kuettner KE,et al.The effect of chemically modified tetracy clines on cartilage degra-dation in chicken tibial explants.Trans Orthop Res SOC,1995;20:337
16 Yu LP Jr,Smith GN Jr,Brandt KD,et al.Reduc-tion of the severity of canineosteo arthritis by pro-phylactictreatment with oraldoxycycline.Arthritis Rheum,1992;35:1150
17 Steinmeyer J,Daufeldt S,Kalbhen DA.Pharma-co logic influence on the activity of stromely sin from bovine articular car tilage.Ann NY Acad Sci,1994;732:482
18 Brandt K:insights into the natural history of os-te oar thritis provided by the cruciate-deficient dog.Ann NY Acad Sci,1994;732:199
19 Greenwald RA.Trea tment of de structive arthritisdiso rders with MMP inhibitor s:potentialrole of tetracyclines.Ann N Y Acad Sci,1994;732:181
20 De Bri E,Lei W,Svensson O,et al.Effect of an inhibitor of ma trixmetallo proteinases on spontaneous osteoar thritis in guinea pigs.Adv Dent Res,1998;12:82
21 Greenwald R,Golub L,Lav aites B,et al.M inocy-cline inhibits rheumatoid synovial collagenase in vivo and in vitro.J Rheuamatol,1987;14:23
22 Greenwald R,Moak S,Ramaurthy N,et al.Tetra-cy clines suppress metallo proteina seactivity inadju-v ant arthritis,and in combination with flurbiprofen,ameliorate bone damage.J Rheumatol,1992;18:927
23 Yu L,Smith GN,Brandt KD,et al.Preoperativeoral administration of doxycycline reduces collage-nases in extracts of human osteoarthritic cartilage(abstract).Arthritis Rheum,1995;37:S362
24 IsraelHA,Ramamurthy NS,Greenwald R,et al.The potential role of doxycycline in the treatment of osteo arthritis of the temporomandibular joint,Adv Dent Res,1998;12:51
25 Shlopov BV,smith Jr.GN,Co le AA,et al.Dif-ferential patterns of response to doxycycline and t ransforming grow th facto rβ1 in thedown-re gelation of collagenases in osteo arthritic and normal human chondrocytes.Arthristis Rheum,1999;42:719
26 Birkedal-Hansen H.Role of matrix metallopro-teinases in human periodonatal diseases.J Periodon-tal,1993;64:474
27 Golub LM,Lee HM,Ry an ME,et al.Tet racy-clines inhibit connective tissue breakdown by multi-plenon-antimicro bialme chanisms.Adv Dent Res,1998;12:12
28 Golub LM,Ramamurthy NS,Llav aner as A,et al.A chemically modified nonantimicrobial tetracycline(CM T-8)inhibits gingival matrix metalloproteinases,periodontal breakdown,and extra-oralbone loss in ovar iectomizedrats.Ann N Y Acad S ci,1998;878:290
29 Golub LM,Ciancio S,Ramamurthy M,et al.Low-dose doxycy cline the rapy:effect ongingival and crevicular fluid collagenase activity in humans.J Periodont Res,1990;25:321
30 Golub LM,So rsa T,Lee HM.Doxycy cline inhibits neutr ophil (PMN)-type matrix me talloproteinases in human adult periodontitis gingiva.J Clin Periodonto l,1995;22:109
31 GolubLM,Lee HM,G reenwald RA,et al.A matrix me tallopr oteinase inhibitor reduces bone-type colla-gendeg radation fragments and specific collagenase sing ingival crevicularfluid during adult periodonti-tis.Inflamm Res,1997;46:310
32 CroutRJ,Lee HM,Schroeder K,et al.The“cyclic”regimen of low-dosedox ycy cline for adult periodon-tits:ap reliminary study.J Periodont,1996;67:506
33 Liotta LA,Kryggvason W,Moor WGI,et al.Metastaticpotential correlates with enzymaticdeg ra-dation of basement membrane collagen.Nature,1980;284:67
34 Stetler-stevenson WG,Aznovoorian S,Liotta LA.Tumor cell inte ractions with the extracellular matrix during inv asion and metastasis.Ann Rev Cell Bio l,1993;9:541
35 Fife RS,Sledge J R GW.Effects of doxycycline on cancercells in vitro and in vivo.Adv Dent Res,1998;12:94
36 Lokeshw ar BL,Houston-Clark HL,Selzer MG,et al.Potential application of a chemically modifiednon-antimic robialtetraccline (CM T-3) against metastatic prostate cancer.Adv Dent Res,1998;12:97
37 Seftor EA,Seftor REB,Nieva DRC,et al.Appli-cation of chemically modified tetracy clines (CM Ts)in expe rimental models of cancer and arthritis.Adv Dent Res,1998;12:103
38 Masumori N,Tsukamoto T,Miyao N,et al.In-hibitory effect of minocy cline on in vitroinv asion and experiment al me tastasis of mouse renal adeno carci-noma.J Urol,1994;151:1400
39 Vemillo AT,Rifkin BR.Effects of tetracy clines on bone me tabolism.Adv Dent Res,1998;12:56
40 Williams S,Wakisaka A,Zeng QQ,et al.M ino cy-cline prevents the decrease in bone minera ldensity and trabecular bone in ovarie-ctomized aged rats.Bone,1996;19:637
41 Bain S,Ramamurthy NS,Impeduglia T,et al.Tetracycline prevents cancellous bone loss and maintains near-normal rate s of bone formation in strep tozotocindiabe ticrats.Bone,1997;21:147
42 Sasalo T.Ramamurthy NS,Golub LM.Long-term the rapy with a new chemically modified tetracy cline(CMT-8)inhibits bone loss in femurs of ovariec-tomizedrats.Adv Dent Res,1998;12:76

化学修饰后的四环素对牙周疾病、关节炎/风湿性关节炎、恶性肿瘤及骨质疏松的作用

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价