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中国临床药理学与治疗学 ›› 2000, Vol. 5 ›› Issue (2): 124-126.

• 论著 • 上一篇    下一篇

黄芪提取物对小鼠学习记忆及免疫功能的影响1

张艳, 明亮, 李卫平, 李京培, 陈敏珠   

  1. 安徽医科大学药理教研室, 合肥 230032
  • 收稿日期:2000-03-17 修回日期:2000-04-18 出版日期:2000-06-26 发布日期:2020-12-01
  • 作者简介:张艳, 女, 38岁, 副教授。陈敏珠, 女, 66岁, 博士生导师, 教授。
  • 基金资助:
    1 安徽省教委资助项目

Effect of extracts of astralus on learning, memory andimmune function in mice

ZHANG Yan, MING Liang, LI Wei-Ping, LI Jing-Pei, CHEN Min-Zhu   

  1. Department of Pharmacology, Anhui Medical University, Hefei, 230032
  • Received:2000-03-17 Revised:2000-04-18 Online:2000-06-26 Published:2020-12-01

摘要: 目的 观察黄芪提取物对免疫抑制小鼠学习记忆及免疫功能的影响。方法 采用小鼠跳台法测定学习记忆功能;采用吞噬鸡红细胞法检测腹腔巨噬细胞的吞噬功能;采用3H-TdR掺入法测定外周血T淋巴细胞增殖反应;采用ELISA法测定血中IFN-γ含量。结果 黄芪提取物(25,50mg·kg-1,ig,21d)能改善CTX降低的小鼠学习记忆功能,同时能提高降低的单核细胞吞噬能力、T淋巴细胞增殖反应以及血中IFN-γ含量。结论 黄芪提取物可改善小鼠学习记忆功能和具有免疫调节作用。

关键词: 黄芪提取物, 环磷酰胺, 记忆, 免疫功能

Abstract: Aim The effect of extract s of astralus(EA)on learning, memory andimmune function of C TX treated mice was observed.Methods The step-down test was adopted to investiga te learning and memory in mice;the method of enveloping CRBC was adopted to explorethe function of macrophage in abdominal cavity;3H-TdR marking method was used to observe the prolifernation of Tlymphocytes and the method of ELISA was applied to measurethe concentration of IFN-γin blood.Results EA (25 mg·kg-1, 50 mg·kg-1, ig, 21 d)could boost learning and memory, enhance the phagocytic activity of monocytes and the proli feration of Tlymphocytes of C TX treated mice, andincrease the concentration of IFN-γin blood of CTX treated mice.Conclusion EAnot only promote learning and memory, butregulate immune function.

Key words: extracts of astralus, cytoxan, memory, immune function

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