格列嗪及二甲双胍对Ⅱ型糖尿病人血清胰岛素样生长因子-1,2的影响

中国临床药理学与治疗学 ›› 2001, Vol. 6 ›› Issue (1): 38-40.

格列嗪及二甲双胍对Ⅱ型糖尿病人血清胰岛素样生长因子-1,2的影响

裴剑浩, 杨华章, 邝建, 廖晓征, 陈重, 陈红梅, 李忠文, 崔炎棠

广东省人民医院, 广州 510080

收稿日期:2000-08-08 修回日期:2000-11-17 发布日期:2020-12-01
作者简介:裴剑浩, 男, 37 岁, 博士研究生, 副主任医师, 主要从事糖尿病研究。崔炎棠, 男, 62 岁, 主任医师, 广东省内分泌学会副主委。

Effects of glipizide and metformin on serum insulin-like growth factor-1, 2 in patients with type Ⅱ diabetes mellitus

PEI Jian-Hao, YANG Hua-Zhang, KUANG Jian, LIAO Xiao-Zhen, CHENG Chong, CHENG Hong, LI Zhong-Wen, CUI Yan

Department of Endocrinology, The Hospital of Guangdong Province, Guangzhou 510080

Received:2000-08-08 Revised:2000-11-17 Published:2020-12-01

摘要/Abstract

摘要： 目的探讨临床常用的口服降糖药物格列吡嗪及二甲双胍和对Ⅱ型糖尿病人血清胰岛素样生长因子-1, 2(IG F-1, 2)的影响。方法采用治疗前后自身对照研究, 分别给予格列吡嗪或二甲双胍治疗2w k, 比较两种药物对Ⅱ型糖尿病患者空腹IGF-1,IGF-2 血清水平的影响。结果二甲双胍治疗组(25例)空腹血清IGF-1, IGF-2 治疗后无明显变化;格列吡嗪(40 例) 治疗后空腹血清IGF-1 升高[ (181.8±104.5)v s (209.0 ±88.2)ng·ml^-1,(P <0.05)], IGF-2 治疗后无明显变化;治疗后2组血糖均明显下降(P 均<0.01), 格列吡嗪组治疗后C 肽水平明显升高(P <0.05), 二甲双胍组治疗后C 肽水平无明显变化。结论格列吡嗪和二甲双胍对Ⅱ型糖尿病患者血清IGF-1 水平有不同的影响。

关键词: 胰岛素样生长因子, Ⅱ型糖尿病, 格列吡嗪, 二甲双胍

Abstract: Aim To study the effects of glipizide and meh formin on the serum IGF-1, IGF-2 in patients with type II diabetes mellitus; Methods The effect of glipizide (n =40) and metformin(n =25) on serum IGF-1, IGF-2 in patients with type I diabetes mellitus were compared with self-controlled study. Results In metformin treated patients, there were not significantly changes in fasting IGF-1 and IGF-2 concentrations In glipizide-treated patients there were markedly increased IGF-1 concentrations (181 8±104.5) vs (209.0 ±88.2)ng·ml^-1(P<0.05) while serum IGF-2 was not change. There was a significant reduction of blood glucose in two groups at the end of treatment (both P <3.01) but C-peptide level was markedly increased(P <0.05) only in glipizi detreated patients. Conclusion The changes of IGF-1 is markedly different between metformin-treated and glipizide-treated patients with type II diabetes mellitus.

Key words: insulin-like growth factor, type H diabetes mellitus, glipizide, metformin

中图分类号:

R969.1

裴剑浩, 杨华章, 邝建, 廖晓征, 陈重, 陈红梅, 李忠文, 崔炎棠. 格列嗪及二甲双胍对Ⅱ型糖尿病人血清胰岛素样生长因子-1,2的影响[J]. 中国临床药理学与治疗学, 2001, 6(1): 38-40.

PEI Jian-Hao, YANG Hua-Zhang, KUANG Jian, LIAO Xiao-Zhen, CHENG Chong, CHENG Hong, LI Zhong-Wen, CUI Yan. Effects of glipizide and metformin on serum insulin-like growth factor-1, 2 in patients with type Ⅱ diabetes mellitus[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2001, 6(1): 38-40.

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