螺旋藻多糖对环磷酰胺所致小鼠骨髓抑制的实验研究

中国临床药理学与治疗学 ›› 2001, Vol. 6 ›› Issue (1): 46-48.

螺旋藻多糖对环磷酰胺所致小鼠骨髓抑制的实验研究

王德俊, 盛树青, 李瑞琴, 孙云, 张洪泉

扬州大学医学院, 扬州 225001

收稿日期:2000-09-26 修回日期:2000-11-02 发布日期:2020-12-01
作者简介:王德俊, 男, 50 岁, 硕士生导师, 副教授。

Polysaccharide of spirulina on the prophylaxis and treatment of myelosup- pression of mice caused by cyclophosphamide

WANG De-Jung, SHENG Shu-Qing, LI Rui-Qing, SUN Yun, ZHANG Hong-Quan

Medical College Yangzhou University, Yangzhou 225001

Received:2000-09-26 Revised:2000-11-02 Published:2020-12-01

摘要/Abstract

摘要： 目的研究螺旋藻多糖对小鼠骨髓造血功能的增强作用。方法将小鼠分成4 组:对照组、环磷酰胺模型组、螺旋藻多糖30 mg·kg^-1、螺旋藻多糖60mg·kg^-1。模型组、螺旋藻多糖组腹腔注射环磷酰胺造模。同时螺旋藻多糖组灌胃螺旋藻多糖, 对照组、模型组灌胃生理盐水。结果螺旋藻多糖在30、60mg·kg^-1剂量下, 对环磷酰胺所致小鼠外周血象、骨髓有核细胞均有改善(P <0.01) 。对骨髓细胞微核增加有明显的拮抗作用(P <0.05) 。螺旋藻多糖组小鼠骨髓细胞染色体畸变率较模型组显著降低,其抑制率分别为51.2%、61.5 %。结论螺旋藻多糖可抑制环磷酰胺诱发的小鼠造血功能损伤。

关键词: 螺旋藻多糖, 骨髓抑制, 环磷酰胺, 微核, 染色体畸变

Abstract: Aim The effect of polysaccharide of spirulina on mouse myelosuppression induced by cyclophosphamide was studied. Methods Mice in the model, treatment groups I and H were given cyclophosphamide (ip 100 mg·kg^-1) for there days. At the same time mice in the treatment groups I and II were given ig spirulin 30 mg·kg^-1 and 60 mg·kg^-1 for ten days, while mice in the control group and model group were given ip 20 mg·kg^-1 of NS. Peripheral blood and marrow cytometry, micromcelsus and chromosome aberration were analyed. Results In the dosages of 30 and 60 mg·kg^-1 polysaccharide of spirulina the polysaccharide of spirulina had perfect action on the perihem ateikon and the function of bone hematoplast induced by cyclophosphamide (P＜0.01) and antagonistic action on increase of bone cell micro nuclsus(P ＜0.05); The ratio of chromosome aberration in the treated group was lower compared with that in the model group. The inhibitory ratio was 51.2% and 62.5% in the treated groups I and II. Conclusion Polysaccharide of spirulina can perfect the hematoplast function of mice injured by cyclophosphamide.

Key words: polysaccharide of spirulina, myelosuppression, cyclophosphamide, micronuclsus, chromosome aberration

中图分类号:

R969.2

王德俊, 盛树青, 李瑞琴, 孙云, 张洪泉. 螺旋藻多糖对环磷酰胺所致小鼠骨髓抑制的实验研究[J]. 中国临床药理学与治疗学, 2001, 6(1): 46-48.

WANG De-Jung, SHENG Shu-Qing, LI Rui-Qing, SUN Yun, ZHANG Hong-Quan. Polysaccharide of spirulina on the prophylaxis and treatment of myelosup- pression of mice caused by cyclophosphamide[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2001, 6(1): 46-48.

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