切割球囊和血管内放射治疗支架内再狭窄的近期疗效观察

中国临床药理学与治疗学 ›› 2001, Vol. 6 ›› Issue (4): 307-310.

切割球囊和血管内放射治疗支架内再狭窄的近期疗效观察

叶飞, 陈绍良, 段宝祥, 黄进, 刘志忠, 宋杰

南京市第一医院心内科, 南京 210006

收稿日期:2001-07-19 修回日期:2001-08-26 出版日期:2001-08-26 发布日期:2020-11-30
作者简介:叶飞, 男, 主治医师, 研究生, 从事冠脉介入治疗及再狭窄的研究。

Short-term results of cutting balloon and intravascular brachytherapy for the treatment of coronary in-stent restenosis

YE Fei, CHEN Shao-Liang, DUAN Bao-Xiang, HUANG Jin, LIU Zhi-Zhong, SONG Jie

Department of Cardiology, Nanjing First Hosptial, Nanjing 210006

Received:2001-07-19 Revised:2001-08-26 Online:2001-08-26 Published:2020-11-30

摘要/Abstract

摘要： 目的研究切割球囊(CBA) 和切割球囊联合血管内放射(IBT) 治疗支架内再狭窄(IS R) 的可行性, 并比较两组的疗效。方法对41 例支架内再狭窄患者47 处病变随机分成3 组, 对照组12 例14 处病变,仅以普通球囊扩张治疗;CBA 组14 例15 处病变,主要以切割球囊治疗;CBA +IBT 组15 例18 处病变, 以切割球囊联合血管内放射治疗为主。随访6～8 mon, 观察终点为观察期间出现心绞痛(AP) 伴随同以往相似的心电图改变、心肌梗死(MI)、目标血管病变处的血运重建(TLR)、非目标血管病变处的血运重建等(N TLR)。如无以上情况, 则行冠状动脉造影检查, 对比3 组的参照血管直径(RVD)、最小管腔直径(MLD)、即刻所得(AG)、后期丢失(LL)、丢失指数(LI) 等参数, 并观察其再再狭窄(RRS) 的情况。结果 3 组的AP、MI、TLR、N TLR的发生率相似, 无显著性差异(P>0.05);而CBA组和CBA +IBT 组的LL、LI、RRS 明显低于对照组, 而CBA 组的AG 明显高于其他两组, 并均有显著性差异(P<0.05)。结论 CBA 和IBT 均能有效的防治IRS, CBA 的疗效似更优于CBA +IBT。

关键词: 切割球囊, 支架, 血管内放射治疗, 再狭窄再再狭窄

Abstract: Aim To evaluate and compare the feasibility and clinical outcomes of cutting balloon angioplasty (CBA) and cutting balloon combined with intravascular brachy therapy (IBT) for the treatment of coronary in-stent restenosis.Methods 41 patients (47 lesions) with in-stent restenosis(ISR) were randomly divided into three groups, the patients in the control group were t reated by plain old balloon angioplasty (POBA), and in CBA group with CBA, and in CBA +IBT group by CBA combined with IBT.All the patients were followed up for 6 to 8 months.The end-points of the observ ation were angina pectoris (AP) accompanied by elect rocardiog ram changes similar to before the t reatment, myocardial infarction (MI), target-lesion revascularization (TLR) and nontarget-lesion revascularization (N TLR).If no thing happened, acute gain (AG), late loss (LL), loss index (LI), and re-restenosis (RRS) w ould be compared among the three groups by quantitat ive coronary angiography after 6 to 8 months.Results The incidences of AP, MI, TLR and NTLR were similar in three groups(P>0.05);the levels of LL, LI, RRS in CBA group and CBA +IBT group were significantly lower than those in control group (P<0.05) and AG in CBA group was higher than that in other two groups(P<0.05).Conclusion CBA and IBT are effective in treatment of ISR, and CBA seems to be prior to CBA +IBT.

Key words: cut ting balloon, stent, intravascular brachy therapy, restenosis, re-restenosis

中图分类号:

R972.6

叶飞, 陈绍良, 段宝祥, 黄进, 刘志忠, 宋杰. 切割球囊和血管内放射治疗支架内再狭窄的近期疗效观察[J]. 中国临床药理学与治疗学, 2001, 6(4): 307-310.

YE Fei, CHEN Shao-Liang, DUAN Bao-Xiang, HUANG Jin, LIU Zhi-Zhong, SONG Jie. Short-term results of cutting balloon and intravascular brachytherapy for the treatment of coronary in-stent restenosis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2001, 6(4): 307-310.

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