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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (2): 115-118.

• 基础研究 • 上一篇    下一篇

神经节苷脂GM1 对新生鼠缺血缺氧后NOS表达的影响1

胡志兵, 陆雪芬2, 郑德枢2, 邓平2, 李婉媚   

  1. 广州市第十二人民医院神经内科, 广州 510620;
    2广州医学院神经科学研究所, 广州 510180
  • 收稿日期:2001-11-29 修回日期:2001-12-25 出版日期:2002-04-26 发布日期:2020-11-27
  • 通讯作者: 胡志兵, 男, 硕士, 从事脑血管疾病的基础和临床研究。Tel:020-85591881-3705 Email:meidle @fm365.com
  • 基金资助:
    1 广东省医学科研基金资助项目(NoB2001101)

Expressions of nitric oxide synthase in neonatal rat after hypoxia-ischemia and their changes while ganglioside GM1 administrated1

HU Zhi-Bing, LU Xue-Fen2, ZHENG De-Shu2, DENG Ping, LI Wan-Mei   

  1. Department of Neurology, The 12th Hospital of Guangzhou, Guangzhou 510620;
    2Neuroscience Institute of Guangzhou Medical College, Guangzhou 510180
  • Received:2001-11-29 Revised:2001-12-25 Online:2002-04-26 Published:2020-11-27

摘要: 目的: 探讨神经节苷脂GM1 对新生儿缺氧缺血性脑病的保护作用及可能机理。 方法:通过建立新生鼠缺氧缺血性脑病动物模型, 观察缺血缺氧后不同时期脑组织的病理变化和一氧化氮合酶(NOS)表达, 以及 GM1 对其影响。结果: GM1 给药组脑组织损伤明显减轻, 缺血缺氧可诱导脑组织中 NOS 表达水平上调, GM1 部分地抑制了缺血缺氧后 NOS 的表达水平。 结论: GM1 对新生儿缺氧缺血性脑损伤具有一定程度的保护作用, 其作用可能是通过部分抑制NOS 的表达。

关键词: 神经节苷脂 GM1, 缺氧缺血性脑病, 新生鼠, 一氧化氮合酶

Abstract: AIM: To study the neuroprotective effect and possible mechanism of ganglioside GM1 on neonatal hypoxic-ischemic-encephalopathy( HIE).METHODS: A rat model of neonatal HIE was established, then the pathological changes and expressions of nitric oxide syn-thase (NOS) in the brain tissueswere investigated in dif-ferent periods after hypoxia-ischemia (HI) and the subse-qent changes of the above results after GM1 administrated. RESULTS: The damage of the brain exposed to HI were alleviated significantly after GM1 administrated.The lev-els of NOS expressions in the brain tissue increased after HI. GM1 could inhibit NOS expressions induced by HI.CONCLUSION: GM1 may have some protective effects on neonatal HIE, and the possible mechanism is related to the partial inhibition of NOS expression .

Key words: ganglioside GM1, hypoxic-ischemic-en-cephalopathy, neonatal rat, nitric oxide synthase

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