关键词: 华法令, 抗凝, 心脏瓣膜, 尿纤维蛋白肽A

Abstract: AIM: To observe the coagulation state in different periods of oral warfarin anticoagulation (OWAT), and to estimate the role of uFPA in evaluating OWAT effect.METHODS: Initial group (n=20) and follow-up group (n=20) were the patients respectively at 14 days and 0.5 to 20 years after heart valve replacement with a range of INR 1.8-2.8.Ten healthy volunteers were regarded as control group.The blood and urine samples were taken and measured.The contents of protein C (PC ), platelet granulate membrane protein 140 (GMP140 ), 6-keto-PGF1α(6-K-F1α) and D-2-Dimer (D2D), the activity of antithrombin Ⅲ (AT Ⅲ), and tissue-plasminogen activator (t-PA) urine fibrinopeptide A (uFPA) were measured.RESULTS: Coagulation process was inhibited during OWAT as well as fibrinolysis process activited at some extent.At the same levels of INR, coagulation process during OWAT was inhibited at a more low and steady level in the follow-up group than in the initial group.CONCLUSION: The variation of coagulation system is complex and fibrinolysis should be considered in analyising the OWAT complications, and uFPA is more accurate and senstive than INR to judge the activited levels of coagulation process during OWAT.If the fibrinolysis is relatively steady, it can reflect the whole anticoagulation effects of OWAT.

Key words: fibrinopeptide A, warfarin, heart valve, Anticoagulation