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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (4): 289-292.

• 基础研究 •    下一篇

组胺对离体兔中枢和外周血管收缩作用的比较及其机理初探

汪慧菁, 吴爱珍, 姚明辉   

  1. 复旦大学上海医学院药理学系, 上海 200032
  • 收稿日期:2002-04-20 修回日期:2002-05-13 出版日期:2002-08-26 发布日期:2020-11-24
  • 通讯作者: 姚明辉, 博士生导师, 复旦大学上海医学院药理学系主任。Tel:021-64041900-2715 E-mai l:mhyao @shmu. edu. cn
  • 作者简介:汪慧菁, 女, 硕士研究生, 研究方向为平滑肌药理。Tel:021-64041900-2690 E-mail:f adeleaf@sohu. com

Comparison of vasoconstrictive effect of histamine on the isolated rabbit central and peripheral arteries in vitro and its mechanism

WANG Hui-Jing, WU Ai-Zhen, YAO Ming-Hui   

  1. Department of Pharmacology, Shanghai Medical College, Fudan University, Shanghai 200032
  • Received:2002-04-20 Revised:2002-05-13 Online:2002-08-26 Published:2020-11-24

摘要: 目的: 比较组胺及其受体阻断药对离体家兔脑及外周血管的作用;并观察钙离子在组胺效应机制中的作用。方法: 取家兔基底动脉和肠系膜动脉,分别在不同剂量苯海拉明、西咪替丁和硝苯地平存在的情况下, 观察组胺量效曲线的变化。结果: 组胺可引起基底动脉和肠系膜动脉收缩;苯海拉明可拮抗组胺的上述作用;西咪替丁小剂量时即可增强组胺所致的基底动脉的收缩, 而大剂量时才对组胺引起的肠系膜动脉收缩有增强作用;硝苯地平对组胺引起的两种动脉的收缩都有抑制作用。结论: 组胺对离体家兔脑及外周血管均有收缩作用, 这种缩血管作用主要通过Ca2+内流引起。同时, 实验结果提示两种血管上组胺受体的分布密度有差别。

关键词: 组胺, 苯海拉明, 西咪替丁, 硝苯地平, 基底动脉, 肠系膜动脉

Abstract: AIM: To compare the effects of histamine and its antagonists on tension of isolated rabbit basilar and mesenteric artery in vitro, and to observe the role of Ca2+ in histamine-induced response. METHODS: The doseresponse curves induced by histamine were recorded on the isolated rabbit central and peripheral arteries in different doses of diphenhydramine, cimitidine, and nifidipine. RESULTS: Histamine could cause contraction of basilar and mesenteric isolated arteries. Diphenhydramine and nifidipine antagonized these effects, while cimitidine enhanced this effect. CONCLUSION: There may be different receptors densities in different rabbit arteries; histamine shows the vasoconstrictive effect on both brain and mesenteric arteries; and the vasoconstrictive effect mainly produces via Ca2+ inflax.

Key words: histamine, diphenhydramine, cimitidine, nifidipine, artery

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