欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (4): 337-338.

• 临床研究 • 上一篇    下一篇

血液灌流抢救超大剂量地高辛中毒

杨红军, 原新茹, 张锡刚, 牛文凯   

  1. 军事医学科学院附属医院血透室, 北京 100039
  • 收稿日期:2001-12-27 修回日期:2002-03-20 出版日期:2002-08-26 发布日期:2020-11-24
  • 通讯作者: 杨红军, 女, 主要从事血液净化治疗和急性毒物药物中毒的救治工作。Tel:010-66874713 E-mai l:yanghj31 @yahoo. com. cn

Hemoperfusion in treatment of overdose digoxin poisoning

YANG Hong-Jun, YUAN Xin-Ru, ZHANG Xi-Gang, NIU WEN-Kai   

  1. Affiliated Hospital to Academy of Military Medical Sciences, Beijing 100039
  • Received:2001-12-27 Revised:2002-03-20 Online:2002-08-26 Published:2020-11-24

摘要: 目的: 观察1例血液灌流抢救超大剂量( 50mg)地高辛中毒的效果。方法: 使用HA 330 ml 灌流器和YT-160 灌流器, 血管通路为股静脉单针双腔导管。入院后共进行了4 次血液灌流( HP) 治疗。结果: 第1 次HP 前后检测地高辛血药浓度均16 μg·L-1。第2 次HP 血药浓度9. 22 μg·L-1。第3 次HP 前血药浓度12. 4 μg·L-1, HP 后为10. 45 μg·L-1。第4 次HP 前3. 22 μg·L-1, HP 后为2. 84 μg·L-1结论: 采用间隔一定的时间HP, 多次进行, 可阶梯式降低药物浓度。

关键词: 地高辛, 血液灌流, 中毒

Abstract: AIM: To observe the efficacy of hemoperfusion ( HP) to treat one case suffering from overdose digoxin poisoning. METHODS: HA 330 ml and YT-160 hemoperfusion cartridges were used and blood vessel was femoral vein, single needle and two-chamber catheter. Four HP were done. RESULTS: The blood digoxin level were 16 μg·L-1 before and after the 1st HP, 9. 22 μg· L-1 at the 2nd, 12. 4 μg·L-1 before the 3th, 10. 45 μg· L-1after the 3th, 3. 22 μg ·L -1before the 4th, and 2. 84 μg·L-1 after the 4th HP. CONCLUSION: This case demonstrats that multiple HP at different period may decrease the blood digoxin level step by step.

Key words: digoxin, hemoperfusion, poisoning

中图分类号: