舒咽灵软胶囊的抗炎、抗菌和免疫调节作用

中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (5): 417-420.

舒咽灵软胶囊的抗炎、抗菌和免疫调节作用

王宇翎, 李前进, 江勤, 张艳, 明亮

安徽医科大学药理教研室, 合肥230032

收稿日期:2002-04-20 修回日期:2002-05-15 发布日期:2020-11-26
通讯作者: 王宇翎, 女, 硕士, 讲师。Tel:0551-5120077
作者简介:张艳, 女, 教授, 主要研究抗炎免疫药理学。

Anti-inflammatory, anti-bacterial and immune regulation effects of shuyanling soft capsule

WANG Yu-Ling, LI Qian-Jin, JIANG Qin, ZHANG Yan, MING Liang

Department of Pharmacology, Anhui Medical University, Heifei 230032

Received:2002-04-20 Revised:2002-05-15 Published:2020-11-26

摘要/Abstract

摘要： 目的研究舒咽灵软胶囊的抗炎、抗菌和免疫调节作用, 为其临床应用提供药效学基础。方法采用小鼠耳片肿胀法和大鼠松节油气囊肉芽增生法,观察舒咽灵软胶囊的抗炎作用;通过体内、体外抗菌试验, 观察抗菌作用。此外, 通过观察对小鼠脾淋巴细胞增殖反应的影响, 对小鼠抗体形成细胞的影响,以及对白细细胞吞噬功能的影响, 确定其免疫调理作用。结果在体外, 舒咽灵软胶囊对16 种细菌均有程度不同的抑菌作用及杀菌作用, 且该药对球菌作用优于杆菌;在体内, 对金葡菌及伤寒杆菌感染的小鼠均具有保护作用;还能程度不同地增强小鼠的中性粒细胞吞噬功能、促进脾脏抗体形成细胞活性及促进小鼠脾T 细胞及B 细胞的转化能力;对小鼠及大鼠急慢性炎症均有抑制作用。结论舒咽灵软胶囊具有抗炎、抗菌及免疫调节作用。

关键词: 舒咽灵软胶囊, 抗炎作用, 抗菌作用, 免疫调节作用

Abstract: AIM: To observe anti-inflammatory, anti- bacterial and immune regulation effects of shuyanling soft capsule. METHODS: The dimethylbenzene-induced the degree of ear swelling in mice and turpentine-induced proliferation in rats were used to observe the anti-inflammation effects of shuyanling soft capsule.The anti-bacterial effects were observed both in vitro and in vivo.The immune regulation effects were studied by the splenocyte proliferation response, the activity of antibody-producing cells and the phagocytosis of leukocyte in mice. RESULTS: Shuyanling soft capsule inhibited dimethylbenzene- induced the degree of ear swelling in mice and turpentine- induced proliferation in rats, protected the mice from the infections of staphylcoccus aureus and salmonella typhi, and repressed sixteen kinds of bacterium in vitro. Furthermore, the capsule remarkably enhanced the phagocytosis of neutropil and increased the activity of spleen antibody-producing cells and the transformation of the T and B cell in spleen in mice. CONCLUSION: Shuyanling soft capsule has anti-inflammatory, anti-bacterial and immune regulation effects.

Key words: shuyanling soft capsule, anti-inflammation, anti-bacterium, immune

中图分类号:

R285.5

王宇翎, 李前进, 江勤, 张艳, 明亮. 舒咽灵软胶囊的抗炎、抗菌和免疫调节作用[J]. 中国临床药理学与治疗学, 2002, 7(5): 417-420.

WANG Yu-Ling, LI Qian-Jin, JIANG Qin, ZHANG Yan, MING Liang. Anti-inflammatory, anti-bacterial and immune regulation effects of shuyanling soft capsule[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(5): 417-420.

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