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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (5): 434-436.

• 研究原著 • 上一篇    下一篇

川芎嗪的鼻腔吸收及冰片的促进作用

许卫华, 王晖1, 许卫铭1   

  1. 广东医学院附属医院耳鼻喉科, 1药理教研室, 湛江 524023
  • 收稿日期:2002-06-10 修回日期:2002-07-15 发布日期:2020-11-26
  • 通讯作者: 许卫华, 男, 本科, 主治医生, 主要从事耳鼻喉科临床工作。Tel:0759-2388588 E-mai l:xwming @gdmc.edu.cn
  • 作者简介:王晖, 男, 硕士, 副教授, 硕士生导师, 主要从事皮肤及粘膜药理学研究。

Nasal absorption of ligustrazine and promotion action of synthetic borneol

XU Wei-Hua, WANG Hui1, XU Wei-Ming1   

  1. Department of Otorhinolaryngology of Affiliated Hospital, 1Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023
  • Received:2002-06-10 Revised:2002-07-15 Published:2020-11-26

摘要: 目的 探讨川芎嗪的鼻腔吸收及冰片的促进作用。 方法 采用大鼠在体鼻腔重循环法, 研究川芎嗪鼻腔吸收的量效关系及冰片对其鼻腔吸收的影响。 结果 循环液中川芎嗪的浓度在0.25, 0.75,1.25 g·L-1时, 鼻腔的吸收速率常数分别为0.0195、0.0227、0.0241 min-1;但当药液浓度为2.5, 5.0g·L-1时, 鼻粘膜吸收速率常数随川芎嗪浓度的增加反而减少。 结论 川芎嗪可通过鼻腔吸收, 冰片对其鼻腔吸收具有促进作用。

关键词: 川芎嗪, 冰片, 鼻腔吸收, 吸收速率常数

Abstract: AIM: To investigate the nasal absorption of ligustrazine and promotion action of synthetic borneol. METHODS: In situ nasal recirculation method was used to study the dose-effect relationship of nasal absorption of ligustrazine and the effect of synthetic borneol on nasal absorption of ligustrazine in rats. RESULTS: When the concentrations of ligustrazine were 0.25, 0.75, and 1.25g·L-1in circulation liquid, respectively, the corresponding values of the absorption rate constant k were 0.0195, 0.0227, and 0.0241 min-1.However, when the concentrations were 2.5 and 5.0 g·L-1 in circulation liquid, the absorption rate constant k lowered with the concentration being added. CONCLUSION: Ligustrazine can be absorbed through the nasal mucous and synthetic borneol can promote the absorption.

Key words: ligustrazine, synthetic borneol, nasal absorption, absorption rate constant

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