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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (5): 446-448.

• 研究原著 • 上一篇    下一篇

联合吸入硫酸镁及沙丁胺醇治疗哮喘的临床研究

许长琼, 杨径, 孟新科   

  1. 广东省深圳市第二人民医院急诊内科, 深圳 518029
  • 收稿日期:2002-06-10 修回日期:2002-07-15 发布日期:2020-11-26
  • 通讯作者: 许长琼, 女, 主治医师。主要从事哮喘的临床治疗和发病机制研究。Tel:0755-3531025 E-mai l:zhangxie @t ech.topway.com.cn

Clinical study of salbutamol combined with magnesium sulfate by nebulization in the treatment of paroxysmal asthma

XU Chang-Qiong, YANG Jing, MENG Xing-Ke   

  1. Emergency Department, Shenzhen Second People's Hospital, Shenzhen 518029
  • Received:2002-06-10 Revised:2002-07-15 Published:2020-11-26

摘要: 目的 探讨联合吸入7.5 %等渗硫酸镁及1 %沙丁胺醇对发作期哮喘患者肺功能的影响。 方法 将75 例发作期哮喘患者随机分成A、B、C3 组, 每组25 人。A 组雾化吸入7.5 %等渗硫酸镁溶液3 ml后间歇5 min, 再吸入生理盐水3 ml。B 组雾化吸入0.1 %沙丁胺醇3 ml 后, 间歇5 min 再吸入生理盐水3 ml。C 组雾化吸入0.1 %沙丁胺醇3 ml 后, 间歇5 min 再雾化吸入7.5 %等渗硫酸镁溶液3 ml。于吸药前、后15 min 分别作用力肺活量(FVC)、1 秒钟用力呼气容积(FEV1)、最大呼气流量(PEF) 的检查,并分别测A、C 两组吸药前后收缩压、舒张压、心率、呼吸的变化。 结果 3 组吸药前后肺功能指标占其正常预计值的百分比浓度(FVC %、FEV1 %、PEF %) 比较均有显著性差异(P <0.05);3 组间吸药后15 min肺功能比较:B 组显著高于A 组(P <0.05);C 组非常显著高于B 组(P <0.01) 和A 组(P <0.01)。A组及C 组吸药前后收缩压、舒张率、心率和呼吸频率差异均无显著性(P >0.05)。 结论 联合吸入7.5 %等渗硫酸镁及1 %沙丁胺醇对发作期哮喘患者的治疗有协同作用, 能明显改善通气功能, 且对患者的血压、心率、呼吸无明显影响。

关键词: 哮喘, 硫酸镁, 沙丁胺醇, 雾化吸入

Abstract: AIM: To explore the efficacy of salbutamol combined with magnesium sulfate by nebulization in the treatment of paroxysmal asthma. METHODS: All of 75 asthma patients were divided into three groups of A, B, and C (n =25):A group treated with 3ml of 7.5 % isoosmotic magnesium sulfate solution and 3ml of physiology saline 5 minutes later;B group treated with 3 ml of 0.1 % salbutamol solution and 3ml of Physiology saline 5 minutes later;C group treated with 3 ml of 0.1 % salbutamol solution and 3 ml of 7.5 % isoosmotic magnesium sulfate solution 5 min later.Forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF) in the three groups were tested before and after the treatment 15min respectively;systolic, diastolic, heart rates and respirations were tested between group A and group C as well. RESULTS: Significant differences were found in ratios (FVC %, FEV1 %, PEF %) of actual indexes of lung function (FVC, FEV1, PEF) to the predicted indexes between before and after treatment in the three groups (P < 0.05).The lung function of B group was higher than that of A group (P <0.05) and C higher than A and B (P < 0.01).There was not significant difference between A and C groups in systolic, diastolic, heart rates and respirations before and after treatment (all of P <0.05). CONCLUSION: There is a synergism in the nebulization inspirating of 0.1 % salbutamol combined with 7.5 % isoosmotic magnesium sulfate in the treatment of paroxysmal asthma.It can improve ventilation function, but does not affect the blood pressure, heart rates and respirations.

Key words: asthma, magnesium sulfate, salbutamol, nebulization

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