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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (6): 504-507.

• 研究原著 • 上一篇    下一篇

三类降血压药物联合治疗皮质下动脉硬化性脑病方案的随机对照研究

陈春富, 曹秉振, 沈君, 常高峰, 尚明谦, 曹霞, 金善, 吕伟   

  1. 济南军区总医院神经内科,济南 250031
  • 收稿日期:2002-08-06 修回日期:2002-08-28 出版日期:2002-12-26 发布日期:2020-11-20
  • 通讯作者: 陈春富,男,医学博士,主要从事脑血管病、痴呆、癫痫研究。Tel:0531-2166208  E-mail:drcf chen@hotmail.com

Randomized and contrast study on the combined effects of three antihypertensive drugs in the patients with subcortical arteriosclerotic encephalopaphy

CHEN Chun-Fu, CAO Bing-Zhen, SHEN Jun, CHANG Gao-Feng, SHANG Ming-Qian, CAO xia, JIN Shan, LU Wei   

  1. Department of Neurology,Jinan Military General Hospital,Jinan 250031
  • Received:2002-08-06 Revised:2002-08-28 Online:2002-12-26 Published:2020-11-20

摘要: 目的 对比观察三类降血压迟效制剂和三类普通制剂联合应用对皮质下动脉硬化性脑病患者血压的影响。方法 皮质下动脉硬化性脑病患者66例,随机分为迟效制剂组33 例与普通制剂组33 例。分别口服迟效和普通剂型钙通道阻滞剂、β 受体阻断剂和血管紧张素转换酶抑制剂,连续口服用药10wk 。动态观察患者心率、血压的变化。评估治疗前后病人日常生活活动独立程度。结果 迟效制剂组与普通制剂组降压总有效率分别为93.9%和87.9%(P >0.05)。迟效制剂对昼夜血压具有平稳的降压作用。不良反应发生率迟效制剂组和普通制剂组分别为15.2%和42.4%(P <0.05)。迟效制剂组不良反应多为轻度且一过性,对心率无明显影响。2 组治疗后病人日常生活活动独立程度均无明显变化(P >0.05)。结论 降血压迟效制剂治疗皮质下动脉硬化性脑病的疗效好,耐受性好。

关键词: 皮质下动脉硬化性脑病, 血压, 钙通道阻滞剂, β受体阻断剂, 血管紧张素转换酶抑制剂, 迟效制剂

Abstract: AIM: To compare the effects of three types of antihypertensive drugs of delayed-action preparation(DAP)and three types of typical preparation(TP)on the blood pressure of patients with subcortical arteriosclerotic encephalopaphy.METHODS: Sixty-six patients with subcortical arteriosclerotic encephalopaphy were randomly divided into DApgroupand Tpgroup,each groupincluding 33 patients.Three types of antihypertensive drugs of DApand TP,including calcium antagonist,β-receptor blocker and angiotensin converting enzyme inhibitor,were used orally in respective groupfor ten consecutive weeks.Blood pressure and heart ratewere monitored dynamically.Activities of daily living(ADL)of each patient were investigated before and after treatment.RESULTS: Total effective rates of antihypertension were 93.9% and 87.9% in DApgroupand in Tpgroup,respectively(p>0.05).The effects of DApwere found to be stable in day time and at night.The rates of side effects were 15.2% and 42.4%(p<0.05)in DApgroupand Tpgroup,respectively.Most side effects were mild and transient in DApgroup,without significant effect on the heart rate.There was not significant change on ADL scores in both groups after the treatment(p>0.05).CONCLUSION: Antihypertensive drugs of ADpare effective agents with a good tolerance in treatment of hypertensive patients with subcortical arteriosclerotic encephalopathy.

Key words: subcortical arteriosclerotic encephalopathy, blood pressure, calcium antagonist, β-receptor blocker, angiotensin converting enzyme inhibitor, delayed-action preparations

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