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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (6): 522-524.

• 研究原著 • 上一篇    下一篇

缬沙坦、氨氯地平对老年高血压病患者血小板活化及纤溶活性的影响及比较

王山岭, 王丽霞, 孙月和1   

  1. 河南省人民医院心内科,郑州 450003;
    1郑州大学第一附属医院心内科,郑州 450052
  • 收稿日期:2002-07-23 修回日期:2002-07-29 出版日期:2002-12-26 发布日期:2020-11-20
  • 通讯作者: 王山岭,男,副主任医师,医学硕士,主要从事心血管疾病的临床研究和介入治疗工作。Tel:0371-5580669  E-mail:wangshanling0209@hotmail.com

Effect of valsartan and amlodipine on platelet activation and fibrinolytic activity in elderly patients with essential hypertension

WANG Shan-Ling, WANG Li-Xia, SHUN Yue-He   

  1. Department of Cardiology,People' s Hospital of Henan Province,Zhengzhou 450003
  • Received:2002-07-23 Revised:2002-07-29 Online:2002-12-26 Published:2020-11-20

摘要: 目的 探讨缬沙坦、氨氯地平对老年高血压病(EH)患者血小板活化及纤溶活性的影响。方法 采用双抗体夹心酶联免疫吸附法和发色底物法分别测定30 例正常老年人和57 例老年EH 患者血浆中血小板α颗粒膜蛋白(GMP-140)和组织型纤溶酶原激活剂(t-PA)及其抑制物(PAI-1)水平。57 例老年EH患者应用缬沙坦(29 例)或氨氯地平(28 例)治疗12wk 。结果 老年EH 患者GMP-140 含量、PAI-1 活性明显升高(p<0.001或p<0.01),t-PA 活性明显降低(p<0.01);GMP-140 含量与PAI-1 水平呈正相关(p<0.01)。治疗后,老年EH 患者GMP-140 含量及PAI-1 活性均明显下降(p<0.01;p<0.05),t-PA活性显著升高(p<0.05),两用药组间差异无显著性(P>0.05)。结论 老年EH 患者血小板功能及纤溶活性异常;缬沙坦、氨氯地平均能有效抑制血小板活化、改善纤溶活性。

关键词: 缬沙坦, 氨氯地平, 高血压, 血小板活化, 纤溶活性

Abstract: AIM: To observe platelet activation and fibrinolytic activity and evalute the effects of valsartan and amlodipine in elderly patients with essential hypertension.METHODS: Double antibody sandwich ELISA and spectrophotometric assay were used to examine the levels of platelet alpha-granule membrane protein(GMP-140),tissue-type plasminogen activator(t-PA)and its inhibitor(PAI-1)in 57 elderly patients with essential hypertension and 30 normotensives.Valsartan was given in 29 cases(groupⅠ)and amlodipine in 28 cases(groupⅡ)for 12 weeks.RESULTS: Elevated GMP-140,decreased t-PA activity,and elevated PAI-1 activity were detected in the patients,but not in normotensives(p<0.01).Levels of GMP-140 were positively correlated with PAI-1 in the patients(p<0.01).GMP-140 and PAI-1 activity were decreased(p<0.01 -0.05),but t-PA activity was increased(p<0.05)after treatment in both group.No significant difference was found in therapeutic effect between groupⅠ and groupⅡ.CONCLUSION: In elderly patients with essential hypertention,the platelet activation elevates and fibrinolytic activity decreases,and both valsartan and amlodipine can inhibit platelet activation and improve fibrinolytic activity.

Key words: alsartan, amlodipine, hypertension, platelet activation, fibrinolytic activity

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