欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (6): 525-528.

• 研究原著 • 上一篇    下一篇

双黄连注射液家兔直肠给药的药代动力学和相对生物利用度研究1

黎烈荣, 谭异伦2, 郑颂3   

  1. 湖北中医学院妇科教研室,武汉 430061;
    2武汉大学中南医院中医科,武汉 430061;
    3汉市第一医院妇产科,武汉 430061
  • 收稿日期:2002-07-22 修回日期:2002-08-13 出版日期:2002-12-26 发布日期:2020-11-20
  • 通讯作者: 黎烈荣,女,硕士,主任医师,硕士生导师,湖北省中医药学会妇产科专业委员会主任委员。Tel:027-67813383  E-mail:llr2@163.com
  • 基金资助:
    1 湖北省教育厅研究项目(No98C029)

Pharmacokinetics and relative bioavailability of shuanghuanglian injection in rabbits by rectal medication1

LI Lie-Rong, TAN Yi-Lun2, ZHENG Song3   

  1. Department of Gynecology,Hubei College of Traditional Chinese Medicine,Wuhan 430061;
    2Department of Traditional Chinese Medicine,Wuhan University,Wuhan 430061;
    3First People Hospital of Wuhan City,Wuhan 430061
  • Received:2002-07-22 Revised:2002-08-13 Online:2002-12-26 Published:2020-11-20

摘要: 目的 研究双黄连注射液家兔直肠给药的药代动力学和相对生物利用度,对保留灌肠和口服给药进行比较,为直肠给药的科学性提供理论依据。方法 将双黄连注射液中主药金银花的有效成分绿原酸作为血药浓度定量分析的检测指标,根据药物由用药部位进入体循环的速度(即吸收速率Ka)和药物进入体循环的相对量,即吸收程度,通常用血药浓度时间(C T)曲线下面积作指标,观察直肠给药的吸收动力学变化。结果 药代动力学数据说明保留灌肠组与口服组间的AUC 存在显著性差异(P <0.05)。灌肠剂的生物利用度为100%,口服剂的相对生物利用度则为80.78%;保留灌肠剂和口服剂的达峰时间(Tp 值)分别是0.75 和2.48 h,有显著的统计学意义(P <0.05),说明保留灌肠在吸收速度方面优于口服;Cmax受吸收量和吸收时间的影响,保留灌肠剂的血清浓度峰值与口服剂的峰值间存在显著性差异(P <0.05),说明保留灌肠剂的血药浓度明显高于口服剂。结论 双黄连注射液有效成分的吸收,直肠比口服给药快,血药浓度高,其吸收总量和生物利用度均高于口服给药。

关键词: 慢性盆腔炎, 中医药疗法, 药代动力学, 直肠给药

Abstract: AIM: To investigate the pharmacokinetics and relative bioavailability of shuanghuanglian injection in rabbits by rectal medication in comparison with oral medication.METHODS: Chlorogenic aci from flos loniceraed,a main component in shuanghuanglian injection,was used as a detection marker in blood drug.According to the velocity of drug entering into systemic circulation from medication site(that is,absorption rate Ka)and the relative quantity of drug entering into systemic circulation from medication site(that is,absorption degree),AUC was usually used as a marker to observe absorption dynamic changes of rectal medication.RESULTS: There was significant difference of AUC between clusis groupand oral group(p<0.05).Bioavailability of enema was 100%,and oral dose 80.87%;The values of Tp of enema and oral dose were 0.75 h and 2.48 h,respectively(p<0.05),showing that clusis was superior to oral medication;Cmax was affected by absorption quantity and time.There was significant difference of Cmax between enema and oral dose(p<0.05),showing that the blood drug concentration of enema was obviously higher than that of oral dose.CONCLUSION: For the chlorogenic acid from shuanghuanglian injection,the absorption in rectal medication is faster than that in oral medication,and the blood concentration,total absorption quantity and bioavailability of rectal medication are higher than ones of oral medication.

Key words: chronic pelvic inflammatory disease, traditional Chinese medicine, pharmacokinetics, rectal medication

中图分类号: