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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (6): 539-541.

• 研究原著 • 上一篇    下一篇

氯沙坦逆转高血压患者心肌肥厚及心肌纤维化的作用

林文辉, 宋于康, 马湘俊   

  1. 浙江省温岭市第一人民医院心内科,温岭 317500
  • 收稿日期:2002-09-02 修回日期:2002-09-14 出版日期:2002-12-26 发布日期:2020-11-20
  • 通讯作者: 林文辉,男,硕士,主治医师,主要从事高血压、冠心病的临床和基础研究。Tel:0576-6123688

Reverse effect of losartan on myocardial fibrosis and left ventricular hypertrophy in treatment of essential hypertensive patients

LIN Wen-Hui, SONG Yu-Kang, MA Xiang-Jun   

  1. Department of Cardiology,The First People' s Hospital of Wenling,Wenling 317500
  • Received:2002-09-02 Revised:2002-09-14 Online:2002-12-26 Published:2020-11-20

摘要: 目的 观察氯沙坦对高血压患者心肌肥厚及心肌纤维化的影响。方法 对35 例高血压伴左室肥厚患者用氯沙坦每日50 ~ 100 mg 治疗6 mon,用放疫法测定治疗前后血清中Ⅲ型前胶原(PC Ⅲ)、层粘蛋白(LN)、透明质酸(HA)的含量,用超声心动图检测治疗前后左室质量指数(LVMI)。结果 氯沙坦治疗后,LVMI 和血清PC Ⅲ 、LN 、HA 均显著降低(P<0.05 或P <0.01);血压显著下降(P <0.01)。结论 氯沙坦可显著降低血压,并逆转高血压心肌肥厚及间质纤维化。

关键词: 氯沙坦, 高血压, 左室肥厚, 心肌纤维化

Abstract: AIM: To investigate the effects of losartan on myocardial fibrosis and left ventricular hypertrophy in hypertensive patients.METHODS: 35 essential hypertensive patients with left ventricular hypertrophy were treated with losartan 50 -100 mg for 6 mon.Before and after the treatment,serum procollagen type Ⅲ(PC Ⅲ),laminin(LN),and hyaluronic acid(HA)were measured by radioimmunoassay;and left ventricular mass index(LVMI)was determined with ultrasonic cardiogram.RESULTS: After treatment with losartan:the serum levels of PC Ⅲ,LN,HA,and LVMI were all decreased(p<0.05 or p<0.01),and the blood pressure was also decreased significantly(p< 0.01).CONCLUSION: Losartan can decrease blood pressure,and reverse the left ventricular hypertrophy and myocardial fibrosis in hypertensive patients.

Key words: losartan, hypertension, left ventricular hypertrophy, myocardial fibrosis

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